Study of Hyperlipidimia and Gene Polymorphism Responsible for Fat Metabolism in Cardiovascular Diseases
Keywords:
Hyperlipidimia, Polymorphism, Metabolism
Abstract
Today, overweight and obesity remain one of the most important global health problems in the world. Overweight and obesity are the cause of not only the appearance of all people, but also a number of diseases, including atherosclerosis and cardiovascular diseases, hypertension, ischemic and hemorrhagic stroke, as well as all other serious problems of internal organs. Development of methods for correcting hyperlipidemia based on gene polymorphism, responsible for the metabolism of fats in diseases of the cardiovascular system. Thus, in patients with cardiovascular diseases, hyperthyroidism was corrected for 7 out of three genes: cholesterol, HDL and LDL levels were higher in the original group and lower in the control group.
References
1. Solntseva A.V., E.A. Aksenova, A.V. Sukalo, Gender Differences and Genetic Ginsymorphism of Adiponectin in Children 2010; 221-226 [Solnseva A.V., E.A. Aksenova, A.V. Sukalo, Gendernie razlichiya i geneticheskiy polimorfizm adiponektina and children 2010; 221-226] [In Russ].
2. Romantsov M.G., Goryacheva L.G., Kovalenko A.L. – Antiviral and immunotropic drugs in pediatric practice 2011; Book. 2: 744 [Romansov M.G., Goryacheva L.G., Kovalenko A.L. – Antivovirus and immunotropic preparations v detskoy praktikem 2011; Kn. 2:744 s][In Russ]
3. Netrebenko, the text of a scientific article on the topic "genetics and epigenetics of obesity" advances in modern biology, 2015; 135(2): 128-138 [Netrebenko, tekst nauchnoy stati na temu "genetika i epigenetika ojireniya" uspexi sovremennoy biologii, 2015; 135(2): 128-138][In Russ].
4. Bessesen D. G., Kushner R. Overweight and obesity: Prevention, diagnosis and treatment. - M .: CJSC "Publishing House BINOM". – 2004; 240-241 [Bessesen D. G., Kushner R. Izbitochniy ves i ojirenie: Profilaktika, diagnostika i lechenie. - M.: ZAO "Izd-vo BINOM". 2004; 240-241][InRuss].
5. Biryukova E. V. Molecular-genetic, hormonal-metabolic and clinical aspects of the metabolic syndrome. Auth. dis... doc. - M., 2009; 40. [Biryukova E. V. Molekulyarno-geneticheskie, hormonal-metabolicheskie i klinicheskie aspekti metabolicheskogo sindroma. Avt.dis... dokt. — M., 2009; 40.].
6. Obesity and overweight. WHO Newsletter. No. 311. May 2014 http://www.who.int/mediacentre/factsheets/fs311/en/. The link is active as of 06/29/2016. [Obesity and overweight. Fact sheet. Updated June 2016. WHO Media centre. 2016.]
7. Nasibulina E.S. Association of gene synmorphism fto with overweight in the Russian population // Kazan Medical Journal. – 2012; 93(5): 823-826 [Nasibulina E.S. Assotsiatsiyapolimorfizmagenafto s izbыtochnoymassoytela v rossiyskoypopulyasii // Kazanskiymeditsinskiyjurnal. 2012; 93(5): 823-826.][InRuss].
8. WHO Media Center. Obesity and overweight. News bulletin. February 16, 2018; — https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and-overweight (Date of access: 03.03.2019). [Sentr CMI BOZ. Ojirenie i izbitochniyves.Informatsionniybyulleten. February 16, 2018; https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and overweight (data obrasheniya: 03/03/2019)].
9. Dina C., Meyre D., Gallina S. et al. Variation in FTO contributes to childhood obesity and severe adult obesity // Nat. Genet. 2007; 39:724-726.
10. Frayling T.M., Timpson N.J., Weedon M.N. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity // Science. 2007; 316:889–894.
11. Liu S.T. et al. Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study // Circulation: Cardiovascular Genetics. 2014; 7(3): 344-349.
12. Livingstone K.M. et al. FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomized controlled trials//bmj. 2016; 354:14707.
13. Locke A.E. et al. Genetic studies of body mass index yield new insights for obesity biology //Nature. 2015; 518(7538): 197-206.
14. Loos R. J. F. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity //Nature genetics. 2008; 40(6): 768-775.
15. Ng M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 //The lancet. 2014; 384(9945): 766-781.
16. Yeo G.S. H. The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition //Molecular and cellular endocrinology. – 2014; 397(1-2): 34-41.
17. Nieters A., Becker N., Linseisen J. Polymorphisms in candidate obesity genesand their interaction with dietary intake of n-6 polyunsaturated fatty acids affectobesity risk in a sub-sample of the EPIC-Heidelberg cohort. Eur. J. Nutr. 2002; 41(5): 210-21.
18. Mammès O., Betoulle D., Aubert R., Herbeth B., Siest G., Fumeron F. Association of the G-2548A polymorphism in the 5’ region of the LEP gene with overweight. Ann. Hum. Genet. 2000; 64(Pt 5): 391-4.
19. Nurboev F. E., Djumaev B. Z. DETERMINATION OF EPIDEMIOLOGY OF GENE AND GENOTYPES DETERMINING BODY WEIGHT BY KETLE INDEX INDICATOR:1-5 www.iejrd.comE-ISSN NO:-2349-0721
20. Nurboev.F.E., Djumaev B.Z. The role of genes in the human body in overweight and obesity. Bukhara, New.Day Journal in Medicine.2019.No.3/27.B. 206-211
21. Kodirova, N. U. (2022). MODERN METHODS OF TREATMENT OF CHRONIC LUNG DISEASES. Oriental renaissance: Innovative, educational, natural and social sciences, 2(Special Issue 4-2), 983-988.
22. Nurbaev F.E.,Zhumaev B.Z., Soliev O.O., Savronov E.E. Khozhimetov A.A., Akhmadaliev N.N. “The significance of changes in the activity of enzymes with different intracellular localization in patients with viral hepatitis B” Scientific journal. Infection, Immunity and Pharmacology. 2010 No. 5. 53-55 Tashkent.
23. Nurbaev F.E.,Rakhmatova D.B., Savronov E.E., Soliev O.O. “The choice of prescribing hepatoprotectors in patients with chronic liver diseases” Scientific journal. Problems of biology and medicine 2011. №1. 26-29 pages Samarkand
24. Khotamova R. S. Frequency of Comorbid Conditions in Chronic Heart Failure //Middle European Scientific Bulletin. – 2022. – Т. 24. – С. 260-264.
25. Тошева Х. Б., Кенжаева З. О. Пропаганда здорового образа жизни в селе как механизм сохранения здоровья сельского населения. – 2014.
26. Тошева Х., Кайимова Д. И. Role of heritable factors in development of the metabolic syndrome //Биология и интегративная медицина. – 2017. – №. 1. – С. 132-146.
27. Гадаев А. Г. и др. Роль некоторых маркеров в оценке течения Хронического кардиоренального синдрома. – 2018.
28. Нурбаев Ф. Э., Тошева Х. Б. Скрининг Сердечно-Сосудистых Заболеваний У Спортсменов //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – С. 8-9.
29. Тошева Х., Хазратов У., Нарзиев Ш. РОЛИ ДИСФУНКЦИИ ПОЧЕК В РАЗВИТИИ КОМОРБИДНОСТИ У БОЛЬНЫХ С ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ //Журнал вестник врача. – 2020. – Т. 1. – №. 3. – С. 93-96.
30. Bekmurodovna T. K., Chorievich Z. A. Study of frequency indicators of comorbid states at different functional classes of heart failure //ACADEMICIA: An International Multidisciplinary Research Journal. – 2021. – Т. 11. – №. 3. – С. 2556-2560.
2. Romantsov M.G., Goryacheva L.G., Kovalenko A.L. – Antiviral and immunotropic drugs in pediatric practice 2011; Book. 2: 744 [Romansov M.G., Goryacheva L.G., Kovalenko A.L. – Antivovirus and immunotropic preparations v detskoy praktikem 2011; Kn. 2:744 s][In Russ]
3. Netrebenko, the text of a scientific article on the topic "genetics and epigenetics of obesity" advances in modern biology, 2015; 135(2): 128-138 [Netrebenko, tekst nauchnoy stati na temu "genetika i epigenetika ojireniya" uspexi sovremennoy biologii, 2015; 135(2): 128-138][In Russ].
4. Bessesen D. G., Kushner R. Overweight and obesity: Prevention, diagnosis and treatment. - M .: CJSC "Publishing House BINOM". – 2004; 240-241 [Bessesen D. G., Kushner R. Izbitochniy ves i ojirenie: Profilaktika, diagnostika i lechenie. - M.: ZAO "Izd-vo BINOM". 2004; 240-241][InRuss].
5. Biryukova E. V. Molecular-genetic, hormonal-metabolic and clinical aspects of the metabolic syndrome. Auth. dis... doc. - M., 2009; 40. [Biryukova E. V. Molekulyarno-geneticheskie, hormonal-metabolicheskie i klinicheskie aspekti metabolicheskogo sindroma. Avt.dis... dokt. — M., 2009; 40.].
6. Obesity and overweight. WHO Newsletter. No. 311. May 2014 http://www.who.int/mediacentre/factsheets/fs311/en/. The link is active as of 06/29/2016. [Obesity and overweight. Fact sheet. Updated June 2016. WHO Media centre. 2016.]
7. Nasibulina E.S. Association of gene synmorphism fto with overweight in the Russian population // Kazan Medical Journal. – 2012; 93(5): 823-826 [Nasibulina E.S. Assotsiatsiyapolimorfizmagenafto s izbыtochnoymassoytela v rossiyskoypopulyasii // Kazanskiymeditsinskiyjurnal. 2012; 93(5): 823-826.][InRuss].
8. WHO Media Center. Obesity and overweight. News bulletin. February 16, 2018; — https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and-overweight (Date of access: 03.03.2019). [Sentr CMI BOZ. Ojirenie i izbitochniyves.Informatsionniybyulleten. February 16, 2018; https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and overweight (data obrasheniya: 03/03/2019)].
9. Dina C., Meyre D., Gallina S. et al. Variation in FTO contributes to childhood obesity and severe adult obesity // Nat. Genet. 2007; 39:724-726.
10. Frayling T.M., Timpson N.J., Weedon M.N. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity // Science. 2007; 316:889–894.
11. Liu S.T. et al. Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study // Circulation: Cardiovascular Genetics. 2014; 7(3): 344-349.
12. Livingstone K.M. et al. FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomized controlled trials//bmj. 2016; 354:14707.
13. Locke A.E. et al. Genetic studies of body mass index yield new insights for obesity biology //Nature. 2015; 518(7538): 197-206.
14. Loos R. J. F. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity //Nature genetics. 2008; 40(6): 768-775.
15. Ng M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 //The lancet. 2014; 384(9945): 766-781.
16. Yeo G.S. H. The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition //Molecular and cellular endocrinology. – 2014; 397(1-2): 34-41.
17. Nieters A., Becker N., Linseisen J. Polymorphisms in candidate obesity genesand their interaction with dietary intake of n-6 polyunsaturated fatty acids affectobesity risk in a sub-sample of the EPIC-Heidelberg cohort. Eur. J. Nutr. 2002; 41(5): 210-21.
18. Mammès O., Betoulle D., Aubert R., Herbeth B., Siest G., Fumeron F. Association of the G-2548A polymorphism in the 5’ region of the LEP gene with overweight. Ann. Hum. Genet. 2000; 64(Pt 5): 391-4.
19. Nurboev F. E., Djumaev B. Z. DETERMINATION OF EPIDEMIOLOGY OF GENE AND GENOTYPES DETERMINING BODY WEIGHT BY KETLE INDEX INDICATOR:1-5 www.iejrd.comE-ISSN NO:-2349-0721
20. Nurboev.F.E., Djumaev B.Z. The role of genes in the human body in overweight and obesity. Bukhara, New.Day Journal in Medicine.2019.No.3/27.B. 206-211
21. Kodirova, N. U. (2022). MODERN METHODS OF TREATMENT OF CHRONIC LUNG DISEASES. Oriental renaissance: Innovative, educational, natural and social sciences, 2(Special Issue 4-2), 983-988.
22. Nurbaev F.E.,Zhumaev B.Z., Soliev O.O., Savronov E.E. Khozhimetov A.A., Akhmadaliev N.N. “The significance of changes in the activity of enzymes with different intracellular localization in patients with viral hepatitis B” Scientific journal. Infection, Immunity and Pharmacology. 2010 No. 5. 53-55 Tashkent.
23. Nurbaev F.E.,Rakhmatova D.B., Savronov E.E., Soliev O.O. “The choice of prescribing hepatoprotectors in patients with chronic liver diseases” Scientific journal. Problems of biology and medicine 2011. №1. 26-29 pages Samarkand
24. Khotamova R. S. Frequency of Comorbid Conditions in Chronic Heart Failure //Middle European Scientific Bulletin. – 2022. – Т. 24. – С. 260-264.
25. Тошева Х. Б., Кенжаева З. О. Пропаганда здорового образа жизни в селе как механизм сохранения здоровья сельского населения. – 2014.
26. Тошева Х., Кайимова Д. И. Role of heritable factors in development of the metabolic syndrome //Биология и интегративная медицина. – 2017. – №. 1. – С. 132-146.
27. Гадаев А. Г. и др. Роль некоторых маркеров в оценке течения Хронического кардиоренального синдрома. – 2018.
28. Нурбаев Ф. Э., Тошева Х. Б. Скрининг Сердечно-Сосудистых Заболеваний У Спортсменов //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – С. 8-9.
29. Тошева Х., Хазратов У., Нарзиев Ш. РОЛИ ДИСФУНКЦИИ ПОЧЕК В РАЗВИТИИ КОМОРБИДНОСТИ У БОЛЬНЫХ С ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ //Журнал вестник врача. – 2020. – Т. 1. – №. 3. – С. 93-96.
30. Bekmurodovna T. K., Chorievich Z. A. Study of frequency indicators of comorbid states at different functional classes of heart failure //ACADEMICIA: An International Multidisciplinary Research Journal. – 2021. – Т. 11. – №. 3. – С. 2556-2560.
Published
2022-08-01
How to Cite
Nurbaev, F. E. (2022). Study of Hyperlipidimia and Gene Polymorphism Responsible for Fat Metabolism in Cardiovascular Diseases. Central Asian Journal of Medical and Natural Science, 3(4), 171-178. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/994
Section
Articles
