Drug-Induced Damage to Liver Cell Structure
Keywords:
hepatotoxicity, drug-induced liver injury (DILI), alanine aminotransferase, aspartate aminotransferase
Abstract
The liver, which is the largest gland of the human body, has a tremendous biological activity, playing a leading role in at least 11 important biochemical processes and taking a significant part in 60-70 more. Given this, it is evident that drug damage to the organ, which is involved in many pathological processes, causes serious disturbances in metabolism, immune response, detoxification and antimicrobial protection.
References
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2. Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, Watkins PB, Navarro V, Barnhart H, Gu J, Serrano J; United States Drug Induced Liver Injury Network. Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study// Gastroenterology- 2015. №148(7)1340. С.52.e7.
3. Chalasani NP, Hayashi PH , Bonkovsky HL, Navarro VJ, Lee WM, Fontana RJ. Practice Parameters Committee of the American College of Gastroenterology// ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol.2014;109(7): 950–66; quiz 967.
4. Cornberg M, Tacke F, Karlsen TH. European Association for the Study of the Liver. Clinical Practice Guidelines of the European Association for the study of the Liver – Advancing methodology but preserving practicability. J Hepatol- 2019; №70(1). С.5–7.
5. Ettel M, Gonzalez GA, Gera S, Eze O, Sigal S, Park JS, Xu R. Frequency and pathological characteristics of drug-induced liver injury in a tertiary medical center// Hum Pathol. 2017.№68.P.92–8.
6. Kholmurodovich U. F. Liver Pathology In Rheumatoid Arthritis //Central Asian journal of medical and natural sciences. – 2022. – Т. 3. – №. 1. – С. 11-15.
7. Kholmurodovich U. F. Damage to the digestive system when using non-steroidal anti-inflammatory drugs //European journal of modern medicine and practice. – 2022. – Т. 2. – №. 1. – С. 6-16.
8. Kholmurodovich U. F. Liver Fibrosis-Modern Methods of Diagnostics and Drug Correction //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – Т. 2. – №. 2. – С. 158-167.
9. Leise MD, Poterucha JJ, Talwalkar JA. Drug-induced liver injury// Mayo Clin Proc.- 2014. №89(1). 95–106.
10. Marino G. Management of druge-induced liver disease // Cur. Gastr.Reports. - 2007. Vol. 3. P. 38 – 48.
11. Reuben A, Koch DG, Lee WM; Acute Liver Failure Study Group. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study// Hepatology.-2010. №52(6): 20. С.65–76.
12. Sotoudehmanesh R. Methotrexate Hepatotoxicity in Patients with Rheumatoid Arthritis // Middle East Journal of Digestive Diseases. -2010. Vol.2, № 2. P. 104 – 109.
13. Stine JG, Lewis JH. Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review// Expert Rev Gastroenterol Hepatol-2016. №10 (4).517–36.
14. Stine JG, Chalasani NP. Drug Hepatotoxicity: Environmental Factors// Clin Liver Dis.- 2017.№21(1): 103–13.
15. Stine JG, Chalasani N. Chronic liver injury induced by drugs: A systematic review. Liver Int.-2015. №35(11). С.2343–53.
Published
2022-06-30
How to Cite
Teshayev, S. J., Saidova, M. M., & Umarov, F. H. (2022). Drug-Induced Damage to Liver Cell Structure. Central Asian Journal of Medical and Natural Science, 3(3), 793-800. https://doi.org/10.17605/cajmns.v3i3.876
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