ASSESSMENT OF CHANGES AND COMPLICATIONS CAUSED BY CORONAVIRUS INFECTION IN THE LUNGS USING COMPUTED TOMOGRAPHY

Abstract

Pathogenetically COVID-19 is characterized by viremia, local and systemic immuno-inflammatory process, hyperactivity of the coagulation cascade, endotheliopathy, hypoxia, which leads to the development of micro- and macrothrombosis; proceeds from asymptomatic to clinically pronounced forms with intoxication, fever, vascular endothelium damage, lungs, heart, kidneys, gastrointestinal tract, central and peripheral nervous systems with the risk of complications (ODN, ARDS, PE, sepsis, shock, SPON). The main target of SARS CoV-2 is the lungs. In pathogenesis, 2 mechanisms should be distinguished that mutually burden each other and can lead to the development of ARDS (pathomorphologically diffuse alveolar damage): direct viral damage to alveocytes with the development of immuno-inflammatory syndrome; the development of micro- and macrothrombosis of pulmonary vessels and obstructive thrombo-inflammatory syndrome. Therefore, the disease was named microCLOTS – microCOVID Lung Obstructive Trombovascular Syndrome1. As in the whole world, the incidence of COVID 19 pneumonia in the Republic of Uzbekistan is more than 193,000 people, while there is a steady increase [1.3.5.7.9].