Synthesis of quersetin complex compounds with iron (II) ions assessment of its stability
Keywords:
Flavonoid, quercetin, Quercetin-iron (II) complex, IR-spectrum, stability constant, molar absorption coefficient
Abstract
Complexes of quercetin with iron (II) ions were synthesized, its IR spectra were studied, and it was proven that if Fe-O bond was formed in the 627 cm-1 region of the oscillation, a complex of shifts in several bonds would occur, in addition, the results of the analysis of UV-spectra showed that bathochromic shifts of about 7 nm and 64 nm were detected, and the stability constant of the synthesized complex compound was calculated, according to which the stability constant of the complex formed from the cation Fe (II)
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Makarenko O. A., Levitsky A. P. Physiological functions of flavonoids in plants // Physiology and biochemistry of cultivated plants. – 2013. – V. 45. -№ 2. – P. 100-112.
Wang, British Columbia. Qian, J. Z., Fan, Y., and Tang, J. QSAR study of flavonoid-metal complexes that scavenge OH free radicals // Journal of Molecular Structure. – 2014. – V. 1075. – P. 204-212.
Kawabata K., Mukai R., Ishisaka A. Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability //Food & function. – 2015. – V. 6. – №. 5. – P. 1399-1417.
Qin, X. R., Zhang, M. J., Gao, X. N., Lin, Y., Li, M. A. Study on the antibacterial activity of quercetin //Chemistry & Bioengineering. – 2009. – V. 26. – №. 4. – P. 55-57.
Dolatabadi, J. E. N., Mokhtarzadeh, A., Ghareghoran, S. M., & Dehghan, G. Synthesis, characterization and antioxidant property of quercetin-Tb (III) complex //Advanced pharmaceutical bulletin. – 2014. – V. 4. – №. 2. – P. 101.
Ghosh, N., Chakraborty, T., Mallick, S., Mana, S., Singha, D., Ghosh, B., & Roy, S. Synthesis, characterization and study of antioxidant activity of quercetin–magnesium complex //Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. – 2015. – V. 151. – P. 807-813.
Bukhari, S.B., Memon, S., Mahroof-Tahir, M., and Bhanger, M.I. Synthesis, characterization and antioxidant activity of the copper-quercetin complex // Spectrochimica Acta Part A: Molecular and Biomorphic Spectroscopy. – 2009. – V. 71. – №. 5. – P. 1901-1906.
Leopoldini, M., Russo, N., Chiodo, S., & Toscano, M. Iron chelation by the powerful antioxidant flavonoid quercetin //Journal of agricultural and food chemistry. – 2006. – V. 54. – №. 17. – P. 6343-6351.
Chen, W., Sun, S., Liang, Y., & Song, J. Antioxidant property of quercetin–Cr (III) complex: The role of Cr (III) ion //Journal of Molecular Structure. – 2009. – V. 918. – №. 1-3. – P. 194-197.
Bukhari, S.B., Memon, S., Tahir, M.M., and Bhanger, M.I. Synthesis, characterization and study of the antioxidant activity of the cobalt-quercetin complex // Journal of Molecular Structure. – 2008. – V. 892. – №. 1-3. – P. 39-46.
Dehghan G., Khoshkam Z. Tin (II)–quercetin complex: Synthesis, spectral characterisation and antioxidant activity //Food Chemistry. – 2012. – V. 131. – №. 2. – P. 422-426.
Ferrer, E.G., Salinas, M.V., Correa, M.J., Naso, L., Barrio, D.A., Etcheverry, S.B., Williams, P.A. Synthesis, characterization, antitumor and osteogenic activity of the complex in quercetin with vanadyl (IV) // JBIC Journal of Biological Inorganic Chemistry. – 2006. – V. 11. – №. 6. – P. 791-801.
Jun T., Bochu W., Liancai Z. Hydrolytic cleavage of DNA by the quercetin-zinc (II) complex // Letters on Bioorganic and Medicinal Chemistry. – 2007. – V. 17. – №. 5. – P. 1197-1199.
Zhou, J., Wang, L., Wang, J., & Tang, N. Antioxidative and anti-tumour activities of solid quercetin metal (II) complexes //Transition Metal Chemistry. – 2001. – V. 26. – №. 1. – P. 57-63.
Tan J., Zhu L., Wang B. DNA binding and cleavage activity of quercetin nickel (II) complex //Dalton Transactions. – 2009. – №. 24. – P. 4722-4728.
[Akhmadi S.M., Dekhgan G., Hosseinpurfeyzi M.A., Dolatabadi JEN and Kashanyan S. Preparation, characterization and DNA-binding of the water-soluble quercetin-molybdenum (VI) complex // DNA and Cell Biology. – 2011. – V. 30. – №. 7. – P. 517-523.
Torreggiani, A., Tamba, M., Trinkero, A., and Bonora, S. Copper(II)–quercetin complexes in aqueous solutions: spectroscopic and kinetic properties // Journal of Molecular Structure. – 2005. – V. 744. – P. 759-766.
Raza, A., Xu, X., Xia, L., Xia, C., Tang, J., & Ouyang, Z. Quercetin-iron complex: synthesis, characterization, antioxidant, DNA binding, DNA cleavage, and antibacterial activity studies //Journal of fluorescence. – 2016. – V. 26. – №. 6. – P. 2023-2031.
Vlasova I.V., Zheleznova T.Yu., Vershinin V.I. Choice of model solutions for spectrophotometric assessment of the stability of complex compounds using the method of isomolar series // Vestnik. Omsk University. - 2012.- №2. - P. 127-130.
Stolpovskaya E. V., Trofimova N. N., Babkin V. A., Khutsishvili S. S., Zhitov R. G., Chuparina E. V., Maltsev A. S. Research and optimization of the complex formation reaction of manganese ions (II) with dihydroquercetin in the aquatic environment // Chemistry of vegetable raw materials. – 2020. – №. 3. – P. 47-56.
Stolpovskaya E. V., Trofimova N. N., Babkin V. A., Zhitov R. G. Research and optimization of the reaction of complex formation of cobalt ions with dihydroquercetin in an aqueous medium // Chemistry of plant raw materials. – 2019. – №. 1. – P. 95–104.
Trofimova N. N., Babkin V. A., Vakulskaya T., Chuparina E. V. Study of methods of synthesis, structure and properties of complexes of flavonoids with metal ions. Message 1. Synthesis and determination of the structure of complexes and salts of dihydroquercetin with zinc, copper (II) and calcium in aqueous solutions // Chemistry of vegetable raw materials. – 2012. – №. 2. – P. 51-62.
Trofimova N. N., Stolpovskaya E. V., Babkin V. A. Study of methods of synthesis, structure and properties of complexes of flavonoids with metal ions. Message 2. Optimization of the reaction of complex formation of zinc with dihydroquercetin in the aquatic environment // Chemistry of vegetable raw materials. – 2013. – №. 3. – P. 91-97.
Stolpovskaya E. V., Trofimova N. N., Babkin V. A. Study of methods of synthesis, structure and properties of complexes of flavonoids with metal ions. Message 4. Study of the reaction of complex formation of Ca2+ ions with dihydroquercetin // Chemistry of vegetable raw materials. – 2014. – №. 4. – P. 125-130.
Published
2022-05-28
How to Cite
Ismatov D.M., & Mukhamadiyev N.Q. (2022). Synthesis of quersetin complex compounds with iron (II) ions assessment of its stability . Central Asian Journal of Medical and Natural Science, 3(3), 329-337. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/790
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