Specific Morphological Changes of Peripheric Immunocompetent Members in Sars-Cov-2

Xoshimov B. L.; Allaberganov D.  Sh

doi:10.17605/cajmns.v3i3.712

Xoshimov B. L. Tashkent Medical Academy
Allaberganov D. Sh Tashkent Medical Academy

DOI: https://doi.org/10.17605/cajmns.v3i3.712

Keywords: SARS-CoV-2, spleen, lymphocytes, lymphoid follicles, immune organs

Abstract

Specific morphological changes of immune organs in Covid-19 depend on the general reactivity of the organism, age, sex and the degree of development of the pathological process, if the process develops chronically; many sclerotic and atrophic changes develop in immune organs. In this study, SARS-CoV-2 was characterized by the development of specific sclerotic and atrophic changes in the active areas of the spleen and lymph nodes. In particular, a decrease in lymphocytes in the T and V areas of the lymph node and in the lymphoid follicles of the spleen and a quantitative decrease in the number of T lymphocytes around the pulp arteries were studied. These morphological changes, in turn, lead to a decrease in immunocompetent cells, low local detection of T and V lymphocytes, and the development of mixed-type cellular and humoral immunodeficiency.

References

1. Fedorov D.N., Korosteleva P.A., Zybin D.I., Popov M.A., Tyurina V.M., Varlamov A.V. Morphological and immunohistochemically characteristics of changes in the lymphatic system of the bronchopulmonary group in patients with new coronavirus infection COVID-19 (according to the results of autopsy studies). Almanac of Clinical Medicine. 2020; 48: pp. 37-42.
2. Semenov V.M., Pashinskaya E.S., Pobyarjin V.V., Subbotina I.A., Shlyaxtunov E.A., Veremey I.S., Semenov S.V. Immunohistochemical and molecular-genetic methods of diagnostics of oncological diseases Bulletin of Vitebsk State Medical University, 2017, Tom 16, №2 pp.15-25
3. Morphological diagnostics of lymphatic pathology // WrightD., Eddis B., Leong E. Moscow, Meditsinskaya literatura, 2008, 176 p.
4. Park WB, Kwon NJ, Choi SJ, Kang CK, Choe PG, Kim JY, Yun J, Lee GW, Seong MW, Kim NJ, Seo JS, Oh MD. Virus Isolation from the First Patient with SARS-CoV-2 in Korea. J Korean Med Sci. 2020;35(7): p. 84.
5. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271–80.
6. Wang K, Chen W, Zhou YS, Lian JQ, Zhang Z, Du P, Gong L, Zhang Y, Cui HY, Geng JJ, Wang B, Sun XX, Wang CF, Yang X. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein [Internet].
7. Walls A C, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. 2020;181(2):281–p.92.
8. Perrella A, Trama U, Bernardi FF, Russo G, Monastra L, Fragranza F, Orlando V, Co. Brancatella A, Ricci D, Viola N, et al. Subacute thyroiditis after SARS-CoV-2 infection. J. Clin Endocrinol Metab. 2020;105(7): p. 276.
9. Stafford V V. Use of an immunohistochemical method in diagnostics. RJOAS. 2016 Aug;8(56): pp. 18-21.