Main Article Content

Abstract





The analysis of literary data on clinical efficacy and safety of antihypertensive medicines indicates the significant difference between the original and generic medicines both on therapeutic equivalence and on the frequency and intensity of the expressiveness of adverse side reactions, caused by them.





Keywords

hypertension antihypertensive medicines the original preparation generic drug therapeutic equivalence adverse side effects

Article Details

How to Cite
Abdukarimovna, R. H. (2022). Adverse Changes in the Cardiovascular System Observed when using a Combination of Antihypertensive Drugs. Central Asian Journal of Medical and Natural Science, 3(2), 478-481. https://doi.org/10.17605/OSF.IO/UVM75

References

  1. 1. Belolipetsky N.A., Tolpygina S.N., Zverkov Yu.B. The study of the clinical and pharmacokinetic equivalence of the original and generic amlodipine in patients with mild and moderate arterial hypertension // Rational pharmacotherapy in cardiology. - 2007. - No. 5. - P.39-44.
  2. 2. Zhukova D.Ya., Kovalskaya G.N. original andgeneric drugs in therapeutic practice // Siberian Medical Journal (Irkutsk). - 2011. - No. 7. - P.96-102.
  3. 3. Kutishenko N.P., Yakusevich V.V., Deev A.D. Grade therapeutic equivalence of the original indapamide and generic indapamide in patients with arterial hypertension using a randomized, crossover study // Rational pharmacotherapy in cardiology. - 2007. - No. 2. - P.26-30.
  4. 4. Martsevich S.Yu., Kutishenko N.P., Deev A.D. Studying the therapeutic equivalence of two preparations of amlodipine (original and reproduced) in patients with arterial hypertension. Results of a double-blind randomized cross-over study // Russian Cardiology magazine. - 2004. - No. 4. - P.53-57.
  5. 5. Nedogoda S.V., Marchenko I.V., Chalyabi T.A. Comparative antihypertensive efficacy of generic inhibitors angiotensin-converting enzyme enalapril-renitec (Enap, Ednit, Invoril, Envas and Enam) and the cost of treatment in patients with hypertension // Arterial hypertension. - 2000. - No. 1. - P.52-54.
  6. 6. Tolpygina S.N., Martsevich S.Yu., Shilova E.V. Preparations bisoprolol in a comparative efficacy study and tolerability of the original drug and its generic in patients with mild and moderate arterial hypertension // Cardiovascular therapy and prevention. - 2007. - No. 6. - P.15-21.
  7. 7. Shostak N.A., Rashid M.A., Arinina E.E. Efficiency and safety of using bisogamma and concor for the treatment of arterial hypertension in middle-aged patients // Farmateka. - 2008. - No. 12 (166). - P.81-89.
  8. 8. Federal guidelines for the use of medicines (formulary system). - Issue. XII. – M.: Echo, 2011. - 956 p.