Assessment of the Immune-Inflammatory Relationship in Patients with Chronic Heart Failure with Rheumatoid Arthritis

Khusainova Munira  Alisherovna; Khaydarova  Zarrina  Erkinovna

Khusainova Munira Alisherovna Samarkand State Medical University Assistant of the Department of Propaedeutics of Internal Diseases, Samarkand, Uzbekistan
Khaydarova Zarrina Erkinovna Samarkand State Medical University Assistant of the Department of Propaedeutics of Internal Diseases, Samarkand, Uzbekistan

Keywords: chronic heart failure, rheumatoid arthritis, dyslipidaemia, diastolic dysfunction

Abstract

The aim of the study was to assess the relationship between manifestations of immune inflammation and dyslipidaemia and myocardial morphofunctional parameters in patients with chronic heart failure (CHF) with preserved left ventricular ejection fraction (CHF-EFV) in seropositive rheumatoid arthritis (RA).

Material and methods. The study included 57 women with CHF as a result of coronary heart disease and/or arterial hypertension. All patients had NYHA functional class I and II. All patients were divided into comparable groups: the first included 31 patients with a combination of CHF and seropositive RA, the second included 26 patients without RA. Patients with RA had low to moderate DAS28 activity. The diagnosis of CHF was verified according to ESC criteria, the diagnosis of RA according to EULAR/ACR criteria (2010). In patients with RA the baseline anti-inflammatory drug used was methotrexate in an average dose (12.9±2.5 mg/week). Comparative analysis of basic laboratory and instrumental parameters used at diagnosis and monitoring of CHF, as well as the correlation of manifestations of immunoinflammatory process with dyslipidemia, was carried out in the studied groups. and indicators of diastolic myocardial dysfunction.

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