Иммунологические И Аутоиммунные Нарушения При Различных Миокардитах У Детей
Keywords:
Миокардиты, клиника, диагностика, лечение
Abstract
В данной обзорной статье рассматриваются вопросы, связанные с миокардитами у детей, оих распространенности, сложности и многообразииэтиопатогенеза, многоликой клиники, трудностях лабораторно-инструментальной диагностики и современных, новых подходов к лечению.Особое внимание уделяется иммуннопатогенезу и аутоиммунизации.
References
1. Басаргина Е.Н.// Доктор Ру, 2008, Москва - №3 (40). – С.34-39
2. Caforio AL, Pankuweit S, Arbustini E, et al. Current state of knowledge on etiology, diagnosis, management, and therapy of myocarditis: a position statement of the European society of cardiology working group on myocardial and pericardial diseases. Eur Heart J. 2013;34(33):2636–2648. doi: 10.1093/eurheartj/eht210.
3. Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation. 1996;93:841–842.
4. Терещенко С.Н. Диагностика и лечение миокардитов. Клинические рекомендации. — М., 2019. — 47 с. [TereschenkoSN. Diagnostika i lechenie miokarditov. Klinicheskie rekomendatsii. Moscow; 2019. 47 p. (In Russ).]
5. Heymans S, Eriksson U, Lentonen J, Cooper LT Jr. The quest for new approaches myocarditis and inflammatory cardiomyopathy. J Am Coll Cardiol. 2016;68(21):2348–2364. doi: 10.1016/j. jacc.2016.09.937.
6. Li L, Zhang Y, Burke A, et al. Demographic, clinical and pathological features of sudden deaths due to myocarditis: results from a state-wide population-based autopsy study. Forensic Sci Int. 2017;272:81–86. doi: 10.1016/j.forsciint.2016.
7. Masarone D, Valente F, Rubino M, et al. Pediatric heart failure: a practical guide to diagnosis and management. Pediatr Neonatol. 2017;58(4):303–312. doi: 10.1016/j.pedneo.2017.01.001.
8. Canter CE, Simpson KE. Diagnosis and treatment of myocarditis in children in the current era. Circulation. 2014;129(1):115–128. doi: 10.1161/CIRCULATIONAHA.113.001372.
9. Basso C, Calabrese F, Corrado D, Thiene G. Postmortem diagnosis in sudden cardiac death victims: macroscopic, microscopic and molecular findings. Cardiovasc Res.2001;50:290–300.
10. Vetter VL, Covington TM, Dugan NP, et al. Cardiovascular deaths in children: general overview from the National Center for the Review and Prevention of Child Deaths. Am Heart J. 2015;169(3):426–437. e23. doi: 10.1016/j.ahj.2014.11.014.
11. Клинические рекомендации по детской кардиологии и ревматологии / Под ред. М.А. Школьниковой, Е.И. Алексеевой. — М., 2011. — 512 с. [Klinicheskierekomendatsiipodetskoikardiologiiirevmatologii. Ed by M.A. Shkolnikova, E.I. Alekseeva. Moscow; 2011. 512 р. (In Russ).]
12. Садыкова Д.И. Принципы медикаментозной терапии миокардитов у детей // Вестник современной клинической медицины. — 2013. — T.6. — №3. — С. 54–60. [Sadykova DI. Principles of medical therapy of myocarditis in children. Bulletin of contemporary clinical medicine. 2013;6(3):54–60. (In Russ).]
13. Rodriguez-Gonzalez M, Sanchez-Codez MI, Lubian-Gutierrez M, Castellano-Martinez A. Clinical presentation and early predictors for poor outcomes in pediatric myocarditis: a retrospective study. World J Clin Cases. 2019;7(5):548–561. doi: 10.12998/ wjcc.v7.i5.548.
14. Van Linthout S, Tschope C. Viral myocarditis: a prime example for endomyocardial biopsy-guided diagnosis and therapy. Curr Opin Cardiol. 2018;33(3):325–333. doi: 10.1097/ HCO.0000000000000515.
15. Chang YJ, Hsiao HJ, Hsia SH, et al. Analysis of clinical parameters and echocardiography as predictors of fatal pediatric myocarditis. PLoS One. 2019;14(3):e0214087. doi: 10.1371/journal. pone.0214087.
16. Amabile N, Fraisse A, Bouvenot J, et al. Outcome of acute fulminant myocarditis in children. Heart. 2006;92(9):1269–1273.
17. Vashist S, Singh GK. Acute myocarditis in children: current concepts and management. Curr Treat Options Cardiovasc Med. 2009;11(5):383–391.
18. Durani Y, Egan M, Baffa J, et al. Pediatric myocarditis: presenting clinical characteristics. Am J Emerg Med. 2009;27(8):942–947. doi: 10.1016/j.ajem.2008.07.032.
19. Dasgupta S, Iannucci G, Mao C et al. Myocarditis in the pediatric population: a review. Congenit Heart Dis. 2019;14(5):868–877. doi: 10.1111/chd.12835.
20. Friedrich MG, Sechtem U, Schulz-Menger J, et al. Cardiovascular magnetic resonance in myocarditis: a JACC white paper. J Am Coll Cardiol. 2009;53(17):1475–1487.
21. Cornicelli MD, Rigsby CK, Rychlik K, et al. Diagnostic performance of cardiovascular magnetic resonance native T1 and T2 mapping in pediatric patients with acute myocarditis. J Cardiovasc Magnetic Res. 2019;21(1):40. doi: 10.1186/s12968-019-0550-7.
22. Cooper LT, Baughman KL, Feldman AM, et al. The role of endomyocardial biopsy in the management of cardiovascular disease. A scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology. J Am Coll Cardiol. 2007;50(19):1914–1931. doi: 10.1016/j. jacc.2007.09.008.
23. Hasegawa-Tamba S, Sugi K, Gatate Y, et al. Successful bridgeto-recovery treat-mentin a young patient with fulminant eosinophilic myocarditis: roles of a percutaneous ventricular assist device and endomyocardial biopsy. Case Rep Emerg Med. 2019;2019:8236735. doi: 10.1155/2019/8236735.
24. He B, Li X, Li D. Immunosuppressive treatment for myocarditis in the pediatric population: a meta-analysis. Front Pediatr. 2019;7:430. doi: 10.3389/fped.2019.00430.
25. Li Y, Yu Y, Chen S, et al. Corticosteroids and intravenous immunoglobulin in pediatric myocarditis: a meta-analysis. Front Pediatr. 2019;7:342. doi: 10.3389/fped.2019.00342.
26. Di Bella G, Pizzino F, Calabrò M, et al. New findings and the role of cardiac imaging in myocarditis and related induced cardiomyopathy. Journal of Cardiovascular Echography. 2012; (22):54-59. 10.1016/j.jcecho.2012.03.001.
27. Baughman KL. Diagnosis of myocarditis: death of Dallas criteria. Circulation. 2006; 113:593-5.
28. Tunuguntla H, Jeewa A, Denfield SW. Acute Myocarditis and Pericarditis in Children. Pediatr Rev. 2019; 40(1):14-25.
29. Abzug, M. J. et al. A randomized, double- blind, placebocontrolled trial of pleconaril for the treatment of neonates with enterovirus sepsis. J. Pediatric Infect. Dis. Soc. 5, 53–62 (2016).
30. Amdani, S. M. et al. Successful treatment of fulminant neonatal enteroviral myocarditis in monochorionic diamniotic twins with cardiopulmonary support, intravenous immunoglobulin and pocapavir. BMJ Case Rep. 2018, bcr-2017-224133 (2018).
31. Yuk M. Law, Ashwin K. Lal, Sharon Chen et al. Diagnosis and Management of Myocarditis in Children. A Scientific Statement from the American Heart Association. Originally published 7 Jul 2021. Circulation. 2021;144:e123–e135 https://doi.org/10.1161/CIR.0000000000001001
32. C. Cuppari, Michela Amatruda, Gyancarla Peralta Ceravolo et al. Myocarditis in children - from infection to autoimmunity. July 2020, Journal of Biological Regulators and Homeostatic Agents 34((4 Suppl. 2)):37-41
33. Simpson KE, Cunningham MW, Lee CK et al. Autoimmunity Against the Heart and Cardiac Myosin in Children with Myocarditis. J Card Fail. 2016; 22(7):520-8.
34. Maisch B (2019) Cardio-Immunology of Myocarditis: Focus on Immune Mechanisms and Treatment Options. Front. Cardiovasc. Med. 6:48. doi: 10.3389/fcvm.2019.00048
35. Carsten Tschope, Enrico Ammirati, Biykem Bozkurt et al. Myocarditis and inflammatorycardiomyopathy: current evidenceand future directions. Nature Reviews Cardiology volume 18, pages169–193 (2021) https://doi.org/10.1038/s41569-020-00435
36. Weckbach, L. T. et al. Midkine drives cardiac inflammation by promoting neutrophil trafficking andNETosis in myocarditis. J. Exp. Med. 216, 350–368 (2019).
37. Swirski, F. K. & Nahrendorf, M. Cardioimmunology:the immune system in cardiac homeostasis anddisease. Nat. Rev. Immunol. 18, 733–744 (2018).
38. Anzai, A. et al. Self- reactive CD4(+) IL-3(+) T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis. J. Exp. Med. 216, 369–383 (2019).
39. Saito S, Hiroi Y, Zou Y, et al. beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes. J Biol Chem. 2000; 275(44):34528-33.
40. Alida L.P. Caforio,Niall J. Mahon,Francesco Tona,William J. McKenna. Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance. First published: 10 October 2002,https://doi.org/10.1016/S1388-9842(02)00010-7.
41. Caforio A, Pankuweit S, Charron P, et al. Current state of knowledge on aetiology, diagnosis, management and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. (2013) 34:2636–48. doi: 10.1093/eurheartj/eht210
2. Caforio AL, Pankuweit S, Arbustini E, et al. Current state of knowledge on etiology, diagnosis, management, and therapy of myocarditis: a position statement of the European society of cardiology working group on myocardial and pericardial diseases. Eur Heart J. 2013;34(33):2636–2648. doi: 10.1093/eurheartj/eht210.
3. Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation. 1996;93:841–842.
4. Терещенко С.Н. Диагностика и лечение миокардитов. Клинические рекомендации. — М., 2019. — 47 с. [TereschenkoSN. Diagnostika i lechenie miokarditov. Klinicheskie rekomendatsii. Moscow; 2019. 47 p. (In Russ).]
5. Heymans S, Eriksson U, Lentonen J, Cooper LT Jr. The quest for new approaches myocarditis and inflammatory cardiomyopathy. J Am Coll Cardiol. 2016;68(21):2348–2364. doi: 10.1016/j. jacc.2016.09.937.
6. Li L, Zhang Y, Burke A, et al. Demographic, clinical and pathological features of sudden deaths due to myocarditis: results from a state-wide population-based autopsy study. Forensic Sci Int. 2017;272:81–86. doi: 10.1016/j.forsciint.2016.
7. Masarone D, Valente F, Rubino M, et al. Pediatric heart failure: a practical guide to diagnosis and management. Pediatr Neonatol. 2017;58(4):303–312. doi: 10.1016/j.pedneo.2017.01.001.
8. Canter CE, Simpson KE. Diagnosis and treatment of myocarditis in children in the current era. Circulation. 2014;129(1):115–128. doi: 10.1161/CIRCULATIONAHA.113.001372.
9. Basso C, Calabrese F, Corrado D, Thiene G. Postmortem diagnosis in sudden cardiac death victims: macroscopic, microscopic and molecular findings. Cardiovasc Res.2001;50:290–300.
10. Vetter VL, Covington TM, Dugan NP, et al. Cardiovascular deaths in children: general overview from the National Center for the Review and Prevention of Child Deaths. Am Heart J. 2015;169(3):426–437. e23. doi: 10.1016/j.ahj.2014.11.014.
11. Клинические рекомендации по детской кардиологии и ревматологии / Под ред. М.А. Школьниковой, Е.И. Алексеевой. — М., 2011. — 512 с. [Klinicheskierekomendatsiipodetskoikardiologiiirevmatologii. Ed by M.A. Shkolnikova, E.I. Alekseeva. Moscow; 2011. 512 р. (In Russ).]
12. Садыкова Д.И. Принципы медикаментозной терапии миокардитов у детей // Вестник современной клинической медицины. — 2013. — T.6. — №3. — С. 54–60. [Sadykova DI. Principles of medical therapy of myocarditis in children. Bulletin of contemporary clinical medicine. 2013;6(3):54–60. (In Russ).]
13. Rodriguez-Gonzalez M, Sanchez-Codez MI, Lubian-Gutierrez M, Castellano-Martinez A. Clinical presentation and early predictors for poor outcomes in pediatric myocarditis: a retrospective study. World J Clin Cases. 2019;7(5):548–561. doi: 10.12998/ wjcc.v7.i5.548.
14. Van Linthout S, Tschope C. Viral myocarditis: a prime example for endomyocardial biopsy-guided diagnosis and therapy. Curr Opin Cardiol. 2018;33(3):325–333. doi: 10.1097/ HCO.0000000000000515.
15. Chang YJ, Hsiao HJ, Hsia SH, et al. Analysis of clinical parameters and echocardiography as predictors of fatal pediatric myocarditis. PLoS One. 2019;14(3):e0214087. doi: 10.1371/journal. pone.0214087.
16. Amabile N, Fraisse A, Bouvenot J, et al. Outcome of acute fulminant myocarditis in children. Heart. 2006;92(9):1269–1273.
17. Vashist S, Singh GK. Acute myocarditis in children: current concepts and management. Curr Treat Options Cardiovasc Med. 2009;11(5):383–391.
18. Durani Y, Egan M, Baffa J, et al. Pediatric myocarditis: presenting clinical characteristics. Am J Emerg Med. 2009;27(8):942–947. doi: 10.1016/j.ajem.2008.07.032.
19. Dasgupta S, Iannucci G, Mao C et al. Myocarditis in the pediatric population: a review. Congenit Heart Dis. 2019;14(5):868–877. doi: 10.1111/chd.12835.
20. Friedrich MG, Sechtem U, Schulz-Menger J, et al. Cardiovascular magnetic resonance in myocarditis: a JACC white paper. J Am Coll Cardiol. 2009;53(17):1475–1487.
21. Cornicelli MD, Rigsby CK, Rychlik K, et al. Diagnostic performance of cardiovascular magnetic resonance native T1 and T2 mapping in pediatric patients with acute myocarditis. J Cardiovasc Magnetic Res. 2019;21(1):40. doi: 10.1186/s12968-019-0550-7.
22. Cooper LT, Baughman KL, Feldman AM, et al. The role of endomyocardial biopsy in the management of cardiovascular disease. A scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology. J Am Coll Cardiol. 2007;50(19):1914–1931. doi: 10.1016/j. jacc.2007.09.008.
23. Hasegawa-Tamba S, Sugi K, Gatate Y, et al. Successful bridgeto-recovery treat-mentin a young patient with fulminant eosinophilic myocarditis: roles of a percutaneous ventricular assist device and endomyocardial biopsy. Case Rep Emerg Med. 2019;2019:8236735. doi: 10.1155/2019/8236735.
24. He B, Li X, Li D. Immunosuppressive treatment for myocarditis in the pediatric population: a meta-analysis. Front Pediatr. 2019;7:430. doi: 10.3389/fped.2019.00430.
25. Li Y, Yu Y, Chen S, et al. Corticosteroids and intravenous immunoglobulin in pediatric myocarditis: a meta-analysis. Front Pediatr. 2019;7:342. doi: 10.3389/fped.2019.00342.
26. Di Bella G, Pizzino F, Calabrò M, et al. New findings and the role of cardiac imaging in myocarditis and related induced cardiomyopathy. Journal of Cardiovascular Echography. 2012; (22):54-59. 10.1016/j.jcecho.2012.03.001.
27. Baughman KL. Diagnosis of myocarditis: death of Dallas criteria. Circulation. 2006; 113:593-5.
28. Tunuguntla H, Jeewa A, Denfield SW. Acute Myocarditis and Pericarditis in Children. Pediatr Rev. 2019; 40(1):14-25.
29. Abzug, M. J. et al. A randomized, double- blind, placebocontrolled trial of pleconaril for the treatment of neonates with enterovirus sepsis. J. Pediatric Infect. Dis. Soc. 5, 53–62 (2016).
30. Amdani, S. M. et al. Successful treatment of fulminant neonatal enteroviral myocarditis in monochorionic diamniotic twins with cardiopulmonary support, intravenous immunoglobulin and pocapavir. BMJ Case Rep. 2018, bcr-2017-224133 (2018).
31. Yuk M. Law, Ashwin K. Lal, Sharon Chen et al. Diagnosis and Management of Myocarditis in Children. A Scientific Statement from the American Heart Association. Originally published 7 Jul 2021. Circulation. 2021;144:e123–e135 https://doi.org/10.1161/CIR.0000000000001001
32. C. Cuppari, Michela Amatruda, Gyancarla Peralta Ceravolo et al. Myocarditis in children - from infection to autoimmunity. July 2020, Journal of Biological Regulators and Homeostatic Agents 34((4 Suppl. 2)):37-41
33. Simpson KE, Cunningham MW, Lee CK et al. Autoimmunity Against the Heart and Cardiac Myosin in Children with Myocarditis. J Card Fail. 2016; 22(7):520-8.
34. Maisch B (2019) Cardio-Immunology of Myocarditis: Focus on Immune Mechanisms and Treatment Options. Front. Cardiovasc. Med. 6:48. doi: 10.3389/fcvm.2019.00048
35. Carsten Tschope, Enrico Ammirati, Biykem Bozkurt et al. Myocarditis and inflammatorycardiomyopathy: current evidenceand future directions. Nature Reviews Cardiology volume 18, pages169–193 (2021) https://doi.org/10.1038/s41569-020-00435
36. Weckbach, L. T. et al. Midkine drives cardiac inflammation by promoting neutrophil trafficking andNETosis in myocarditis. J. Exp. Med. 216, 350–368 (2019).
37. Swirski, F. K. & Nahrendorf, M. Cardioimmunology:the immune system in cardiac homeostasis anddisease. Nat. Rev. Immunol. 18, 733–744 (2018).
38. Anzai, A. et al. Self- reactive CD4(+) IL-3(+) T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis. J. Exp. Med. 216, 369–383 (2019).
39. Saito S, Hiroi Y, Zou Y, et al. beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes. J Biol Chem. 2000; 275(44):34528-33.
40. Alida L.P. Caforio,Niall J. Mahon,Francesco Tona,William J. McKenna. Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance. First published: 10 October 2002,https://doi.org/10.1016/S1388-9842(02)00010-7.
41. Caforio A, Pankuweit S, Charron P, et al. Current state of knowledge on aetiology, diagnosis, management and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. (2013) 34:2636–48. doi: 10.1093/eurheartj/eht210
Published
2022-03-22
How to Cite
Юсупова, Г. К., & Ашурова, Д. Т. (2022). Иммунологические И Аутоиммунные Нарушения При Различных Миокардитах У Детей. Central Asian Journal of Medical and Natural Science, 3(2), 184-192. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/648
Section
Articles
