Specific Features of the Hemostatic System in Covid-19
Abstract
This article describes the main clinical characteristics of patients with Covid-19. It's a single-center retrospective cohort study. All COVID-19 patients included in this study were diagnosed according to the guidelines for the diagnosis and treatment of pneumonia caused by infection with the novel coronavirus. All patients had laboratory-confirmed infection with SARS-CoV-2 (real-time RT-PCR specific for SARS-CoV-2 was positive). The value of D- dimer coagulation indices, prothrombin time, activated partial thromboplastin time, thrombin time and fibrinogen as well as C-reactive protein, procalcitonin, ferritin in predicting the severity and prognosis of COVID-19 was studied. Dysfunction of blood coagulation and procalcitonin are widely used to assess the risk of bacterial infection and C-reactive protein - an indicator of an acute inflammatory process - was found in almost everyone, more often in severe patients.
References
2. ZhuN.. Zhang D.. Wang W.: A novel coronavirus from patients with pneumonia in China. 2019. N. Engl. J. Med., 2020: 382: 727-733
3. Obloqulov A.R., Musayeva D M., Elmuradova A.A. Clinical and epidemiological characteristics of the novel coronavirus infection (COVID-19). // New Day in Medicine. 2020. №2 (30/2) С. 110-115.
4. Cao Y. LiuX.. Xiong L. et al. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis. J. Med. Virol., 2020: doi: 10.1002/jmv.25 822.
5. Obloqulov A.R., Narziyev 1.1., Djalolova V.Z. et al. Treatment prospects of COVID-19. //Infection, immunology and farmacy 2020. №3 128-138.
6. Elmurodova A.A. (2021). Significance of Clinical Symptoms in Assessing the Severity and Prognosis of the Course of Crimean-Congo Hemorrhagic Fever. CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES, 35-37. https://doi.org/10.47494/cajmns.vi0.344
7. Levi M„ Thachil J.. Iba T.. Levye J.H.: Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol., 2020; 7 : e438-e440
8. Wang D. Hu В. Hu C et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan. China. JAMA. 2020.
9. Chen N. Zhou M. Dong X. et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive smdy. Lancer. 2020:395:507-513.
10. Khudoydodova S.G., Farmanova M.A. (2021). CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES, 183-186.
11. Tao J, Song Z, Yang L. et al. Emergency management for preventing and controlling nosocomial infection of 2019 novel coronavirus: implications for the dermatology department. B r J Dermatol. 2020:182:1477-1478.
12. Oblokulov, A. R., Niyozov, G.E. (2020) Clinical and epidemiological characteristics of patients with COVID-19 International Journal of Pharmaceutical Research; 12(4):3749-3752.
13. Young В. E. BChir MB, Oug SW Xiang et al. "Epidemiologic Fean ires and Clinical Course of Patients Infected With SARS-CoV-2 hi Singapore", JAMA. Marz 2020. doi: 10.1001/jama.2020.3204.
14. Guan, W., Nt. Z., Hu, Y. et al. Clinical characteristics of 2019 novel coronavirus infection in China //N Engl J Med. 2020; 382 (18): 1708-1720
15. Obloqulov A.R, Oblokulov Z.I, ElmurodovaA.A., Farmanova M.A. Virologic response in the treatment of infection with antiviral drugs. World Journal of Pharmaceutical Research 2020, ISSN 2277-7105. Pp 87-92
