Morphological Features of Spleen at Different Stages  of Postnatal Ontogenesis

Khasanova Dilnoza Ahrorovna

Khasanova Dilnoza Ahrorovna DSc, Associate Professor of the Department of Anatomy, Clinical Anatomy (OSTA)

Keywords: immune system, spleen, lymphoid follicles, genetically postnatal ontogenesis

Abstract

The aim of the study was to study the structural features of the morphology of the spleen in white rats at different stages of postnatal ontogenesis.

Materials and methods of research. The experiment was carried out on 65 male mongrel rats in a newborn and at the age of 3, 6 months. In the preparations, the structures of the spleen were examined morphometrically using an ocular micrometer. The diameter of the periarterial lymphatic couplings of the spleen, lymph nodes and their germinal centers, the width of the mantle, marginal and periarterial zones of lymph nodes, the relative area of connective tissue elements and white pulp (relative to the total area of the cut) were measured.

Results. The spleen of newborn rats is functionally immature, lymph nodes are not fully formed, it is difficult to distinguish all zones in them and germinative centers are not determined. By the six-month period, the spleen has the highest immune activity, manifested by an increase in the number of lymph nodes with a reproduction center and a large number of lymphocytes in them and in the periarterial lymphatic couplings.

Conclusions. It has been established that since the age of nine months, involutive changes are observed, characterized by an increase in the number of connective tissue elements in the spleen, a decrease in germinal centers in lymph nodes, the total number of lymphocytes in lymph nodes without reproduction centers, periarterial lymphatic couplings.

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