Research of the Involvement of Rs2276109 Polymorphism of the Mmp-12 Gene in the Development of Varicose Vein Disease of the Lower Extremities and Deep Vein Thrombosis of the Lower Extremities

  • Alisher Alizhonovich Yariev Syrdara branch of the Republican Scientific Center for Emergency Medical Aid (RSСEMA) of the Ministry of Health of the Republic of Uzbekistan.
  • Kodirjon Tukhtabaevich Boboev Republican Specialized Scientific and Practical Medical Center of Hematology (RSSPMCH) of the Ministry of Health of the Republic of Uzbekistan
Keywords: polymorphism, VVLE, A-82G

Abstract

The presence of the rs2276109 polymorphism of the MMP12 gene in the genotype may be a marker of a hereditary predisposition to the development of rearrangements of the structure of the venous walls and, accordingly, a predictor of the development of varicose veins of the lower extremities (VVLE).

Objective. To reveal the association of the rs2276109 polymorphism of the MMP12 gene with the development of varicose veins of the lower extremities (VVLE) and deep vein thrombosis of the lower extremities (DVTLE).

Materials and methods. The studies were carried out in a group consisting of patients with a hereditary predisposition to VVLE and with phlebothrombosis (n=161). The frequency of detection of the rs2276109 polymorphism in the MMP12 gene was studied in all the subjects of the main and control samples.

References

1. Rabe E, Berboth G, Pannier F. Epidemiologie der chronischen Venenkrankheiten [Epidemiology of chronic venous diseases]. Wien Med Wochenschr. 2016 Jun;166(9-10): 260-263. German. doi: 10.1007/s10354-016-0465-y. Epub 2016 Jun 8. PMID: 27277219.
2. Zolotukhin IA, Seliverstov EI, Shevtsov YN, Avakiants IP, Nikishkov AS, Tatarintsev AM, Kirienko AI. Prevalence and Risk Factors for Chronic Venous Disease in the General Russian Population. Eur J Vasc Endovasc Surg. 2017 Dec;54(6):752-758. doi: 10.1016/j.ejvs.2017.08.033. Epub 2017 Oct 12. PMID: 29031868.
3. Zolotukhin I. A. et al. Varicose veins: on the verge of discovering the cause? //Annals of the Russian academy of medical sciences. – 2020. – Т. 75. – №. 1. – С. 36-45.
4. Bharath V., Kahn S. R., Lazo-Langner A. Genetic polymorphisms of vein wall remodeling in chronic venous disease: a narrative and systematic review //Blood, The Journal of the American Society of Hematology. – 2014. – Т. 124. – №. 8. – С. 1242-1250.
5. Fukaya E, Flores AM, Lindholm D, Gustafsson S, Zanetti D, Ingelsson E, Leeper NJ. Clinical and Genetic Determinants of Varicose Veins. Circulation. 2018 Dec 18; 138(25): 2869-2880. doi: 10.1161/CIRCULATIONAHA.118.035584. PMID: 30566020; PMCID: PMC6400474.
6. Klupp, F., Neumann, L., Kahlert, C. et al. Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients. BMC Cancer 16, 494 (2016) 1-9. https://doi.org/10.1186/s12885-016-2515-7
7. Borghese B., Chiche J.D., Vernerey D., Chenot C. Mir O., Bijaoui G., Bonaiti-Pellié C., Chapron C. Genetic poly morphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression // Hum Reprod. 2008. no. 23. рр. 1207–1213.
8. Su L., Zhou W., Asomaning K., Lin X., Wain J.C., Lynch T.J., Liu G., Christiani D.C. Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cance // Carcinogenesis. 2006. no. 27. рр. 1024–1029.
9. Ye S., Eriksson P., Hamsten A., Kurkinen M., Humphries S.E., Henney A.M. Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression // J Biol Chem. 1996. no. 271. рр. 13055–13060.
10. Шевела А. И., Новак Е.В., Серяпина Ю.В., Морозов В.В., Воронина Е.Н.. Полиморфные варианты генов матриксных металлопротеиназ и VEGF–предикторы варикозной болезни? //Фундаментальные исследования. – 2014. – Т. 7. – №. 10. – С. 1399-1403.
11. Jang-Young Kim. Polymorphisms of MMP-3, MMP-9, MMP-12, and TIMP-1 genes as a determinant of isolated coronary artery ectasia: дис. – Graduate School, Yonsei University, 2007. – С. 1-41.
12. Hollingsworth S.J., Powell G.l., Barker S.G., Cooper D.G. Primary varicose veins: altered transcription of VEGF and its receptors (KDR, fl t-1, soluble fl t-1) with sapheno-femoral junction incompetence // Eur J Vasc Endovasc Surg. 2004. Vol. 27, no. 3. рр. 259-268.
13. Shapiro S.D., Kobayashi8 D.K., Ley T.J. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages // J Biol Chem. 1993. no. 268. рр. 23824-23829.
14. Woodside K. J. et al. Morphologic characteristics of varicose veins: possible role of metalloproteinases //Journal of vascular surgery. – 2003. – Т. 38. – №. 1. – С. 162-169.
15. Seryapina Y. U. V. et al. The genetic predictors of varicose veins of small pelvis: a pilot study //Flebologiya. – 2018. – Т. 12. – №. 1. – С. 25-29.
16. Яровенко Г. В., Фесюн А. В. Рецидив варикозной болезни нижних конечностей //Вестник экспериментальной и клинической хирургии. – 2018. – Т. 11. – №. 3. – С. 183-185.
17. Woodside K. J. et al. Morphologic characteristics of varicose veins: possible role of metalloproteinases //Journal of vascular surgery. – 2003. – Т. 38. – №. 1. – С. 162-169.
18. Slonková V. et al. Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2 //Journal of the European Academy of Dermatology and Venereology. – 2017. – Т. 31. – №. 10. – С. 1746-1752.
Published
2021-12-02
How to Cite
Yariev, A. A., & Boboev , K. T. (2021). Research of the Involvement of Rs2276109 Polymorphism of the Mmp-12 Gene in the Development of Varicose Vein Disease of the Lower Extremities and Deep Vein Thrombosis of the Lower Extremities. Central Asian Journal of Medical and Natural Science, 2(6), 200-205. https://doi.org/10.17605/cajmns.v2i6.506
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Articles