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Abstract

Ongoing research into cancer cures and therapeutic agents is being carried out by scientists worldwide to alleviate the rising burden of this insurmountable illness. Research on lumichrome, a photoproduct of the vitamin riboflavin, led us to discover that it has anticancer properties against lung cancer. More research is needed to determine how effective it is. An anticancer ability of lumichrome and its synthetic derivatives against liver, breast, and colorectal cancer was shown in this work. Cytotoxic activity against Hep3B (liver carcinoma), SkBr3 (Breast adenocarcinoma), and BRAF (Colorectal cancer) cell lines was evaluated using the MTT assay, which is a cytotoxicity test. These results ranged from 8.9 to 23.9 micrograms per milliliter. The IC50 for lumichrome and its synthetic derivative was 8.9 and 16.6 µg/ml, respectively, for Hep3B cells. Activation of apoptosis and interference with transcription is assumed to be the primary mechanisms of action of these substances. The mechanism of action of these products will need to be studied in the future.

Keywords

lumichrome anticancer agent breast cancer liver carcinoma colon cancer

Article Details

How to Cite
Dave Arthur R. Robledo, & Muhammad, G. (2021). Evaluation of the Cytotoxic Properties of Lumichrome-Derived Compounds on Breast Adenocarcinoma, Colorectal Cancer, and Liver Carcinoma. CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES, 2(6), 49-54. https://doi.org/10.47494/cajmns.v2i6.481

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