Spectrophotometric Determination of Trifluoperazine Hydrochloride By Oxidative Coupling Using Schiff Bases As A Reagent

Sura Ekrayym  Ahmed; Reem  Salwan Noman; Haifa Mohammed  Atawi

Sura Ekrayym Ahmed Tikrit University, College of Science, Department of Chemistry
Reem Salwan Noman Tikrit University, College of Science, Department of Chemistry
Haifa Mohammed Atawi Tikrit University, College of Science, Department of Chemistry

Keywords: Trifluoperazine Hydrochloride, Potassium Iodate KIO₃

Abstract

A new spectrophotometric method was developed for the determination of trifluoperazine in aqueous media using the oxidative reaction with the Schiff base reagent (1,3,5-triazin-2,4,6-tril)tris(azanilidene)tris(methanedilidene). This reaction was generated by a 3–5-hour condensation between the aldehyde and an aromatic amine in the presence of glacial acetic acid, resulting in a light yellow precipitate with a molecular weight of 435 g/mol and a chemical formula of C24H21N9. Conjugation occurred at pH 1.28 in the presence of the oxidizing agent potassium iodate, producing a water-soluble product with a maximum absorbance at 548 nm. The product exhibited a stability period of over 70 minutes, sufficient for several measurements, and the Beer's law limits were between 70 and 10 μg/ml of trifluoperazine. The molar absorptivity was 3651.2 L/mol/cm, and the Sandell significance level was 0.131 μg/cm. The method was effective and convenient for testing, with a specificity of 100.49%, a relative error of 1.26%, and a detection limit of 0.208 mg/L. The method was effective in the determination of trifluoperazine in tablet form in pharmaceutical preparations.

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