Exploring the Dual Impact: Assessment of Glaucoma and Dry Eye Syndrome on Patient Outcomes
Abstract
The present study sought to explore the Dual Impact Assessment of Glaucoma and Dry Eye Syndrome on Patient Outcomes. A total of 180 patients from multiple hospitals across Iraq were included in the study, and demographic and baseline patient information was collected. The patients were randomly assigned to two groups over a one-year study period. In this study, a demographic questionnaire was created, including age, sex, height, weight, income, and comorbidities, which were crucial factors in distinguishing between the two groups. The severity of dry eye was categorised as mild, moderate, or severe. The standardized chart was utilized to assess best-corrected visual acuity (BCVA), which was subsequently incorporated into the LogMAR score as an additional criterion. The results obtained in this study were as follows: The mean age of Group 1 was 65.1 years (± 7.9 years), and Group 2 was 66.5 years (± 8.3 years). Group 1 had a higher proportion of mild cases (44.4%), while Group 2 had more moderate and severe dry eye cases (18.9%), suggesting severe ocular discomfort. The condition, known as dry eye syndrome, has been shown to have a significant impact on tear production and overall ocular health. This impact can be evidenced by lower Schirmer test scores and shorter tear breakup times in patients diagnosed with glaucoma. This emphasises the necessity for regular assessment and concurrent management of the condition. Group 2 demonstrated lower retinal layer thickness values in both the retinal nerve fibre layer thickness (RNFLT; 86.5 μm) and the ganglion cell complex-peripheral layer thickness (GCIPLT; 76.6 μm) in comparison to Group 1. Subsequent data demonstrates a gradual decline in adherence rates between the two groups. Thus necessitating interventions to maintain patient engagement and to monitor for early indications of non-adherence. It has been posited that both glaucoma and dry eye syndrome (DES) have dualistic repercussions on the patients' outcomes when it comes to integrated care. Therefore, healthcare practitioners ought to be cognisant of DES in patients with glaucoma in such cases for the purpose of improving adherence and quality of life.
References
A. T. Zhao, J. He, Y. Lei, Y. Chen, and G. S. Ying, "Associations between dry eye disease and mental health conditions in the All of Us Research Program," Am. J. Ophthalmol., vol. 270, pp. 61–66, Feb. 2025.
G. Singh, A. Agarwal, and M. Priya, "Dry eye disease after cataract surgery in a tertiary care hospital in western Uttar Pradesh," unpublished.
Y. H. Choi, M. Kim, Y. H. Choi, and D. H. Kim, "Adult male-specific inverse association between dry eye disease and intraocular pressure: KNHANES 2010–2012," PLoS One, vol. 20, no. 2, p. e0315010, 2025.
E. S. Lee et al., "Cataract surgery and lens implantation," J. Cataract Refract. Surg., vol. 31, pp. 2379–2385, 2005.
J. Altman, G. Jones, S. Ahmed, S. Sharma, and A. Sharma, "Tear film microRNAs as potential biomarkers: A review," Int. J. Mol. Sci., vol. 24, no. 4, p. 3694, 2023.
M. Heydari, M. Kalani, Y. Ghasemi, and M. Nejabat, "The effect of ophthalmic and systemic formulations of Latilactobacillus sakei on clinical and immunological outcomes of patients with dry eye disease: A factorial, randomized, placebo-controlled, and triple-masking clinical trial," Probiotics Antimicrob. Proteins, vol. 16, no. 3, pp. 1026–1035, 2024.
J. L. Gayton, "Etiology, prevalence, and treatment of dry eye disease," Clin. Ophthalmol., pp. 405–412, 2009.
E. M. Messmer, "The pathophysiology, diagnosis, and treatment of dry eye disease," Dtsch. Arztebl. Int., vol. 112, no. 5, pp. 71–81, Jan. 2015.
M. A. Lemp and G. N. Foulks, "The definition and classification of dry eye disease," Ocul. Surf., vol. 5, no. 2, pp. 75–92, 2007.
A. J. Bron et al., "Rethinking dry eye disease: A perspective on clinical implications," Ocul. Surf., vol. 12, no. 2, pp. S1–S31, 2014.
K. J. Maeng et al., "Effects of glaucoma medication on dry eye syndrome and quality of life in patients with glaucoma," Korean J. Ophthalmol., vol. 35, no. 6, p. 467, 2021.
G. C. M. Rossi, C. Tinelli, G. M. Pasinetti, G. Milano, and P. E. Bianchi, "Dry eye syndrome-related quality of life in glaucoma patients," Eur. J. Ophthalmol., vol. 19, no. 4, pp. 572–579, 2009.
E. E. Freeman, B. Muñoz, S. K. West, H. D. Jampel, and D. S. Friedman, "Glaucoma and quality of life: The Salisbury Eye Evaluation," Ophthalmology, vol. 115, no. 2, pp. 233–238, 2008.
L. Quaranta et al., "Quality of life in glaucoma: A review of the literature," Adv. Ther., vol. 33, pp. 959–981, 2016.
J. Benítez-del-Castillo et al., "Visual acuity and quality of life in dry eye disease: Proceedings of the OCEAN group meeting," Ocul. Surf., vol. 15, no. 2, pp. 169–178, 2017.
M. K. Morthen et al., "The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants," Ocul. Surf., vol. 21, pp. 107–117, 2021.
K. S. Na, K. Han, Y. G. Park, C. Na, and C. K. Joo, "Depression, stress, quality of life, and dry eye disease in Korean women: A population-based study," Cornea, vol. 34, no. 7, pp. 733–738, 2015.
S. Barabino, M. Labetoulle, M. Rolando, and E. M. Messmer, "Understanding symptoms and quality of life in patients with dry eye syndrome," Ocul. Surf., vol. 14, no. 3, pp. 365–376, 2016.
U. Aapola et al., "Impact of signs and symptoms of dry eye disease on health-related quality of life: A cross-sectional population study among older adults," Qual. Life Res., pp. 1–14, 2025.
S. Yeo, H. T. Aung, and L. Tong, "The association of dry eye symptoms with socioeconomic factors and quality of life," J. Clin. Res. Ophthalmol., vol. 1, no. 1, pp. 006–013, 2014.
Copyright (c) 2025 Ali Abbas Hassan Fazaa

This work is licensed under a Creative Commons Attribution 4.0 International License.