Effectiveness of Royal Jell on Helicobacter Pylori Bacteria Isolated From Infected Patients

Manal  Dheyaa Mohammed

doi:10.17605/cajmns.v6i2.2743

Manal Dheyaa Mohammed General directorate education of Salah-Aldin, Ministry of education, Iraq

DOI: https://doi.org/10.17605/cajmns.v6i2.2743

Keywords: Royal Jell, Helicobacter Pylori, Clarithromycin, 10HDA

Abstract

This project aimed to know the antibiotic effect of royal jelly produced by Apis mellifera bees against Helicobacter pylori bacteria isolated from infected people. Twenty samples that isolated from stomach infected patients by respiratory. Royal jelly showed an effective effect in inhibiting the bacteria. After knowing the minimum inhibitory concentration (MIC), the following concentrations were chosen (25, 50, 75)% with an average inhibition diameter of (20.00, 24.30, 30.60) respectively. The results showed that the inhibition effectiveness increases when royal jelly is used with the antibiotic clarithromycin at the same concentration, with an average inhibition diameter of (22.10, 28.60, 39.05). The antibiotic clarithromycin is currently used to treat stomach bacteria as part of the triple therapy used for stomach bacteria and ulcers. The effectiveness of royal jelly is due to its containing many active compounds, the most important of which is fatty acid, the most important of which is 10-HDA. (10-Hydroxy-trans-2-Decenoic Acid) which represents 80% of total fatty acids in royal jell and which was detected in this study using the HPLC apparatus High Performance Liquid Chromatography. Patients' irregularity in taking antibiotics leads to a decrease in the acidity of the stomach, which affects the effectiveness of the treatment. This in turn leads to making the bacteria more virulent and the possibility of bacterial mutations occurring at a high rate which made the medication ineffective Therefore, honey bee products are considered natural, do not cause genetic mutations or any bacterial resistance, and do not affect human health compere with antibiotic.

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