Quorum Sensing Between Bacterial Communication and Neutralization to Reduce Bacterial Birulence
Keywords:
QS, N-acylhomoserine lactone, Quorum quenching Lactonases Acylases, Autoinducer and plant extracts
Abstract
One of the important means by which bacteria communicate is the quorum sensing(QS) mechanism, which represents the essential point in starting their journey towards controlling the environment in which they exist through the formation of biofilms, the production of virulence factors, the production of internal and external enzymes, movement, reproduction, and spore formation. Therefore, this review sheds light on how bacterial QS occurs, forming genetic coding and the formation of the regulatory and receptor protein molecules responsible for this and their mechanism of action, to develop our strategy in our battle against mutations and resistance that occur in pathogenic bacteria as a result of the use of synthetic antibiotics and the search for natural chemical compounds extracted from plants that are effective in suppressing bacterial QS without affecting their growth, thus reducing the risk of developing resistance later, as well as getting rid of the toxicity of some drugs used in treatment.
References
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2. Adonizio, A., Leal Jr, S. M., Ausubel, F. M., & Mathee, K. (2008). Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system. Journal of Medical Microbiology, 57(7), 809-813.
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4. Al-Hussaini, R., & Mahasneh, A. M. (2009). Microbial growth and quorum sensing antagonist activities of herbal plants extracts. Molecules, 14(9), 3425-3435.
5. Annapoorani, A., Umamageswaran, V., Parameswari, R., Pandian, S. K., & Ravi, A. V. (2012). Computational discovery of putative quorum sensing inhibitors against LasR and RhlR receptor proteins of Pseudomonas aeruginosa. Journal of computer-aided molecular design, 26, 1067-1077.
6. Boban, T., Nadar, S., & Tauro, S. (2023). Breaking down bacterial communication: a review of quorum quenching agents. Future Journal of Pharmaceutical Sciences, 9(1), 77.
7. Bose, S. K., Chauhan, M., Dhingra, N., Chhibber, S., & Harjai, K. (2020). Terpinen-4-ol attenuates quorum sensing regulated virulence factors and biofilm formation in Pseudomonas aeruginosa. Future Microbiology, 15(2), 127-142.
8. Bouyahya, A., Chamkhi, I., Balahbib, A., Rebezov, M., Shariati, M. A., Wilairatana, P., & El Omari, N. (2022). Mechanisms, anti-quorum-sensing actions, and clinical trials of medicinal plant bioactive compounds against bacteria: a comprehensive review. Molecules, 27(5), 1484.
9. Chambers, C. E., Visser, M. B., Schwab, U., & Sokol, P. A. (2005). Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients. FEMS microbiology letters, 244(2), 297-304.
10. Chen, F., Gao, Y., Chen, X., Yu, Z., & Li, X. (2013). Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection. International journal of molecular sciences, 14(9), 17477-17500.
11. Dhowlaghar, N., Dhanani, T., Pillai, S. S., & Patil, B. S. (2023). Accelerated solvent extraction of red onion peel extract and its antimicrobial, antibiofilm, and quorum-sensing inhibition activities against Listeria monocytogenes and Chromobacterium violaceum. Food Bioscience, 53, 102649.
12. Dong, Y. H., Xu, J. L., Li, X. Z., & Zhang, L. H. (2000). AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora. Proceedings of the National Academy of Sciences, 97(7), 3526-3531.
13. Eberl L, Winson MK, Sternberg C, Stewart GSAB, Christiansen G, Chhabra SR, Bycroft B, Williams P, Molin S, Givskov M (1996) Mol Microbiol 20:127–136.
14. Fuqua, W.C., Winans, S.C., Greenberg, E.P., 1994. Quorum sensing in bacteria: the LuxR–LuxI family of cell density-responsive transcriptional regulators. J. Bacteriol. 176, 269–275.
15. Galloway, W. R., Hodgkinson, J. T., Bowden, S. D., Welch, M., and Spring, D. R. (2011). Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways. Chem. Rev. 111, 28–67. doi: 10.1021/cr100109t.
16. Ganguly, K., Wu, R., Ollivault-Shiflett, M., Goodwin, P. M., Silks III, L. A., & Iyer, R. (2011). Design, synthesis, and a novel application of quorum-sensing agonists as potential drug-delivery vehicles. Journal of Drug Targeting, 19(7), 528-539.
17. Gebler, G. F., & Anriany, Y. A. (2024). PGCC MICROBIOLOGY. https://LibreTexts.org.
18. Geske, G. D., O'Neill, J. C., Miller, D. M., Mattmann, M. E., & Blackwell, H. E. (2007). Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. Journal of the American Chemical Society, 129(44), 13613-13625.
19. Hamrita, B., Noumi, E., Hafi, F., Nazzaro, F., & Snoussi, M. (2022). Phytochemical composition and antimicrobial, and anti-quorum sensing activities of Punica granatum L. methanolic extract. Iranian Journal of Microbiology, 14(3), 373.
20. Hanzelka, B. L., & Greenberg, E. P. (1996). Quorum sensing in Vibrio fischeri: evidence that S-adenosylmethionine is the amino acid substrate for autoinducer synthesis. Journal of bacteriology, 178(17), 5291-5294.
21. Haris, Z., & Ahmad, I. (2024). Evaluation of antioxidant-rich bioactive plant extracts with special reference to Moringa oleifera Lam. for their interference to bacterial quorum sensing and biofilm. Phytomedicine Plus, 4(2), 100511.
22. Hense, B. A., & Schuster, M. (2015). Core principles of bacterial autoinducer systems. Microbiology and Molecular Biology Reviews, 79(1), 153-169.
23. Husain, F. M., Ahmad, I., Khan, M. S., Ahmad, E., Tahseen, Q., Khan, M. S., & Alshabib, N. A. (2015). Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria. Frontiers in microbiology, 6, 420.
24. Janssens, J. C., Steenackers, H., Robijns, S., Gellens, E., Levin, J., Zhao, H., & De Keersmaecker, S. C. (2008). Brominated furanones inhibit biofilm formation by Salmonella enterica serovar Typhimurium. Applied and Environmental Microbiology, 74(21), 6639-6648.
25. Jonnalagadda, S. A. R. A. D. A., & Deshabathini, U. K. (2016). Anti quorum sensing potential of Moringa oleifera seed extract. Int J Pharm Pharm Sci, 8(1), 76-82.
26. Koh, C. L., Sam, C. K., Yin, W. F., Tan, L. Y., Krishnan, T., Chong, Y. M., & Chan, K. G. (2013). Plant-derived natural products as sources of anti-quorum sensing compounds. Sensors, 13(5), 6217-6228.
27. Kumari, A., Pasini, P., & Daunert, S. (2008). Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples. Analytical and bioanalytical chemistry, 391, 1619-1627.
28. LaSarre, B., & Federle, M. J. (2013). Exploiting quorum sensing to confuse bacterial pathogens. Microbiology and molecular biology reviews, 77(1), 73-111.
29. Lee, J. H., Park, J. H., Cho, H. S., Joo, S. W., Cho, M. H., & Lee, J. (2013). Anti-biofilm activities of quercetin and tannic acid against Staphylococcus aureus. Biofouling, 29(5), 491-499.
30. Lin, Y. H., Xu, J. L., Hu, J., Wang, L. H., Ong, S. L., Leadbetter, J. R., & Zhang, L. H. (2003). Acyl‐homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum‐quenching enzymes. Molecular microbiology, 47(3), 849-860.
31. March, J. C., & Bentley, W. E. (2004). Quorum sensing and bacterial cross-talk in biotechnology. Current opinion in biotechnology, 15(5), 495-502.
32. Middleton, B., Rodgers, H. C., Cámara, M., Knox, A. J., Williams, P., & Hardman, A. (2002). Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum. FEMS microbiology letters, 207(1), 1-7.
33. Miller, M. B., & Bassler, B. L. (2001). Quorum sensing in bacteria. Annual Reviews in Microbiology, 55(1), 165-199.Kleerebezem M, Quadri LEN, Kuipers OP, De Vos WM (1997) Mol Microbiol 24:895–904.
34. Moradi, F., Hadi, N., & Bazargani, A. (2020). Evaluation of quorum-sensing inhibitory effects of extracts of three traditional medicine plants with known antibacterial properties. New Microbes and New Infections, 38, 100769.
35. Nazzaro, F., Fratianni, F., & Coppola, R. (2013). Quorum sensing and phytochemicals. International journal of molecular sciences, 14(6), 12607-12619.
36. Nealson, K.H., Platt, T., Hastings, J.W., 1970. Cellular control of the synthesis and activity of the bacterial luminescent system. J. Bacteriol. 104, 313–322.
37. Oh, M. W. (2024). Molecular investigation of competence development by streptococcus pneumoniae during in vivo infection (Doctoral dissertation, University of Illinois at Urbana-Champaign).
38. Paluch, E., Rewak-Soroczyńska, J., Jędrusik, I., Mazurkiewicz, E., & Jermakow, K. J. A. M. (2020). Prevention of biofilm formation by quorum quenching. Applied microbiology and biotechnology, 104, 1871-1881.
39. Papenfort, K., & Bassler, B. L. (2016). Quorum sensing signal–response systems in Gram-negative bacteria. Nature Reviews Microbiology, 14(9), 576-588.
40. Paul, A. A., Kadosh, Y. S., Kushmaro, A., & Marks, R. S. (2024). Microbead-Encapsulated Luminescent Bioreporter Screening of P. aeruginosa via Its Secreted Quorum-Sensing Molecules. Biosensors, 14(8), 383.
41. Pereira, C. S., Thompson, J. A., & Xavier, K. B. (2013). AI-2-mediated signalling in bacteria. FEMS microbiology reviews, 37(2), 156-181.
42. Pereira, C. S., de Regt, A. K., Brito, P. H., Miller, S. T., & Xavier, K. B. (2009). Identification of functional LsrB-like autoinducer-2 receptors. Journal of bacteriology, 191(22), 6975-6987.
43. Rajan, R., Zhu, J., Hu, X., Pei, D., & Bell, C. E. (2005). Crystal structure of S-ribosylhomocysteinase (LuxS) in complex with a catalytic 2-ketone intermediate. Biochemistry, 44(10), 3745-3753.
44. Rehman, Z. U., & Leiknes, T. (2018). Quorum-quenching bacteria isolated from Red Sea sediments reduce biofilm formation by Pseudomonas aeruginosa. Frontiers in microbiology, 9, 1354.
45. Reimmann, C., Ginet, N., Michel, L., Keel, C., Michaux, P., Krishnapillai, V., & Haas, D. (2002). Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1. Microbiology, 148(4), 923-932.
46. Ribeiro, T. A. N., Dos Santos, G. A., Dos Santos, C. T., Soares, D. C. F., Saraiva, M. F., Leal, D. H. S., & Sachs, D. (2024). Eugenol as a promising antibiofilm and anti-quorum sensing agent: a systematic review. Microbial Pathogenesis, 106937.
47. Samrot, A. V., Abubakar Mohamed, A., Faradjeva, E., Si Jie, L., Hooi Sze, C., Arif, A., & Kumar, S. S. (2021). Mechanisms and impact of biofilms and targeting of biofilms using bioactive compounds—A review. Medicina, 57(8), 839.
48. Sana, T. G., Voulhoux, R., Monack, D. M., Ize, B., & Bleves, S. (2020). Protein export and secretion among bacterial pathogens. Frontiers in Cellular and Infection Microbiology, 9, 473.
49. Santos, C. A., Lima, E. M. F., Franco, B. D. G. D. M., & Pinto, U. M. (2021). Exploring phenolic compounds as quorum sensing inhibitors in foodborne bacteria. Frontiers in microbiology, 12, 735931.
50. Sharif, D. I., Gallon, J., Smith, C. J., & Dudley, E. D. (2008). Quorum sensing in Cyanobacteria: N-octanoyl-homoserine lactone release and response, by the epilithic colonial cyanobacterium Gloeothece PCC6909. The ISME journal, 2(12), 1171-1182.
51. Shi-Hui Dong, Mila Nhu-Lam, Rajesh Nagarajan, and Satish K. Nair.(2020). Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities.ACS Chemical Biology, 15 (6), 1497-1504.
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Published
2025-01-17
How to Cite
Ali Kassab, M. (2025). Quorum Sensing Between Bacterial Communication and Neutralization to Reduce Bacterial Birulence. Central Asian Journal of Medical and Natural Science, 6(1), 307-316. https://doi.org/10.17605/cajmns.v6i1.2699
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Articles
Copyright (c) 2025 Mohammad Ali Kassab
This work is licensed under a Creative Commons Attribution 4.0 International License.
