Synthesis, Characterization, and DFT cucalutions, Biological Study of Five-membered Cyclic Containing the sulfur and nitrogen
Keywords:
Thiazolidine-2,4-dione, thermodynamic parameters, biological activities, Gaussian program
Abstract
Thiazolidinediones have biological activity in pharmaceutical industry. The presence of N-3 and C-5 positions in the TZD core scaffold makes it a versatile and flexible piece that exhibits its biological activities. Therefore, two thiazolidinedione derivatives were prepared and their antimicrobial activity was studied. The antibacterial activity was measured and the computational study of the synthesized derivatives was performed using Gaussian program to calculate some important thermodynamic parameters.
References
1. LIMA JG. AlgunsAspectosQuímicos do Anel 2,4–tiazolidinadiona. Rev Uni Rural, SérCiêncExatas e da Terra. 1998;18/20(1/2):1–8.
2. Mohanty S, Reddy SG, Ramadevi B, et al. An assembly of structurally diverse small and simple 5–aminomethylene derivatives of 2,4–thiazolidinedione and studies of their biological activity. Med Chem Res. 2015;24(12):4037–4049.
3. Albrecht, U., Gördes, D., Schmidt, E., Thurow, K., Lalk, M., and Langer, P. (2005). Synthesis and Structure-Activity Relationships of 2-Alkylidenethiazolidine-4, 5-Diones as Antibiotic Agents. Bioorg. Med. Chem. 13 (14), 4402–4407. doi:10.1016/j.bmc.2005.04.046
4. 4-Jain, N., et al. (2013) A Generalized Approach for DG Planning and Viability Analysis under Market Scenario. IEEE Transactions on Industrial Electronics, 60, 5075-5085.https://doi.org/10.1109/TIE.2012.2219840
5. AuhoodKadhimZaid (2022). Synthesis, Characterization, and Computational, Biological Studies of Four-membered Cyclic Amides 2- azetinones. Journal of Chemical Health Risks. 12(4), 665-674 . DOI: 10.22034/jchr.2022.691252.
6. AuhoodKadhimZaid. Synthesis, Characterization, and Computational Study of Novel Thiazolidinone Derivatives Containing the Indole. J. Med. Chem. Sci., 2023, 6(2) 346-354 https://doi.org/10.26655/JMCHEMSCI.2023.2.15
URL: http://www.jmchemsci.com/article_156196.html
7. Beharry-Borg, N., Hensher, D.A. and Scarpa, R. 2009. An Analytical Framework for Joint vs Separate Decisions by Couples in Choice Experiments: The Case of Coastal Water Quality in Tobago. Environmental Resource Economics 43, 95-117.
8. Kim S. H., Ha Y. M., Moon K. M., Choi Y. J., Park Y. J., Jeong H. O., et al. (2013). Anti-Melanogenic Effect of (Z)-5-(2, 4-Dihydroxybenzylidene) Thiazolidine-2,4-Dione, a Novel Tyrosinase Inhibitor. Arch. Pharm. Res. 36 (10), 1189–1197. 10.1007/s12272-013-0184-5
9. Bozdağ-Dündar O., Çoban T., Ceylan-Ünlüsoy M., Ertan R. (2009). Radical Scavenging Capacities of Some Thiazolylthiazolidine-2, 4-Dione Derivatives. Med. Chem. Res. 18 (1), 1–7. 10.1007/s00044-007-9081-0.
10. Avupati V. R., Rani Y., Singh A. (2018). Discovery of a Series of 5-Benzylidene-1, 3-Thiazolidine-2, 4-Dione-Linked Chalcone Hybrids as a Novel Class of 5-Lipoxygenase (5-LO) Inhibitors. J. Young Pharma 10 (2), 241–242. 10.5530/jyp.2018.10.53
11. Malik N. and Prasad D. N., Iranian Journal of Pharmaceutical Sciences, 8, 3,
209-214, 2012.
12. Pattan S. R., Kerkare P., Nikalje A. and Hole M. B., Asian J Res Chem, 2,
123-6, 2009.
13. Ali R., 2011. Synthesis of New Schiff's Bases Derived from 4-Phthalimidyl Acetophenone. Journal of Al-Nahrain. 14(3), 1-8.
14. Medjahed, S.; Belaidi, S.; Djekhaba, S.; Tchouar, N.; Kerassa, A. Computational Study of Molecular Electrostatic Potential, Drug Likeness Screening and Structure-Activity/Property Relationships of Thiazolidine-2, 4-Dione Derivatives. J. Bionanoscience 2016, 10, 118–126.
15. Juma J.M., Vuai S.A., Computational studies of the thermodynamic properties, and global and reactivity descriptors of fluorescein dye derivatives in acetonitrile using density functional theory, Journal of Chemical Research, 2021, 45:800
16. Belaidi, S.; Melkemi, N.; Bouzidi, D. Molecular geometry and structure-property relationships for 1, 2-dithiole-3-thione derivatives. Int. J. Chem. Res.
17. Yeşilkaynak T., Özkömeç F.N., Çeşme M., Demirdöğen R.E., Kutlu E., Kutlu H.M., Emen F.M., Synthesis of new thiourea derivatives and metal complexes: Thermal behavior, biological evaluation, in silico ADMET profiling and molecular docking studies, Journal of Molecular Structure, 2022, 1269:133758Fortune DG, Main CJ, O'Sullivan TM, Griffiths CE, Quality of life in patients with psoriasis: the contribution of clinical variables and psoriasis-specific stress, Br J Dermatol, 1997, 137:755-760.
2. Mohanty S, Reddy SG, Ramadevi B, et al. An assembly of structurally diverse small and simple 5–aminomethylene derivatives of 2,4–thiazolidinedione and studies of their biological activity. Med Chem Res. 2015;24(12):4037–4049.
3. Albrecht, U., Gördes, D., Schmidt, E., Thurow, K., Lalk, M., and Langer, P. (2005). Synthesis and Structure-Activity Relationships of 2-Alkylidenethiazolidine-4, 5-Diones as Antibiotic Agents. Bioorg. Med. Chem. 13 (14), 4402–4407. doi:10.1016/j.bmc.2005.04.046
4. 4-Jain, N., et al. (2013) A Generalized Approach for DG Planning and Viability Analysis under Market Scenario. IEEE Transactions on Industrial Electronics, 60, 5075-5085.https://doi.org/10.1109/TIE.2012.2219840
5. AuhoodKadhimZaid (2022). Synthesis, Characterization, and Computational, Biological Studies of Four-membered Cyclic Amides 2- azetinones. Journal of Chemical Health Risks. 12(4), 665-674 . DOI: 10.22034/jchr.2022.691252.
6. AuhoodKadhimZaid. Synthesis, Characterization, and Computational Study of Novel Thiazolidinone Derivatives Containing the Indole. J. Med. Chem. Sci., 2023, 6(2) 346-354 https://doi.org/10.26655/JMCHEMSCI.2023.2.15
URL: http://www.jmchemsci.com/article_156196.html
7. Beharry-Borg, N., Hensher, D.A. and Scarpa, R. 2009. An Analytical Framework for Joint vs Separate Decisions by Couples in Choice Experiments: The Case of Coastal Water Quality in Tobago. Environmental Resource Economics 43, 95-117.
8. Kim S. H., Ha Y. M., Moon K. M., Choi Y. J., Park Y. J., Jeong H. O., et al. (2013). Anti-Melanogenic Effect of (Z)-5-(2, 4-Dihydroxybenzylidene) Thiazolidine-2,4-Dione, a Novel Tyrosinase Inhibitor. Arch. Pharm. Res. 36 (10), 1189–1197. 10.1007/s12272-013-0184-5
9. Bozdağ-Dündar O., Çoban T., Ceylan-Ünlüsoy M., Ertan R. (2009). Radical Scavenging Capacities of Some Thiazolylthiazolidine-2, 4-Dione Derivatives. Med. Chem. Res. 18 (1), 1–7. 10.1007/s00044-007-9081-0.
10. Avupati V. R., Rani Y., Singh A. (2018). Discovery of a Series of 5-Benzylidene-1, 3-Thiazolidine-2, 4-Dione-Linked Chalcone Hybrids as a Novel Class of 5-Lipoxygenase (5-LO) Inhibitors. J. Young Pharma 10 (2), 241–242. 10.5530/jyp.2018.10.53
11. Malik N. and Prasad D. N., Iranian Journal of Pharmaceutical Sciences, 8, 3,
209-214, 2012.
12. Pattan S. R., Kerkare P., Nikalje A. and Hole M. B., Asian J Res Chem, 2,
123-6, 2009.
13. Ali R., 2011. Synthesis of New Schiff's Bases Derived from 4-Phthalimidyl Acetophenone. Journal of Al-Nahrain. 14(3), 1-8.
14. Medjahed, S.; Belaidi, S.; Djekhaba, S.; Tchouar, N.; Kerassa, A. Computational Study of Molecular Electrostatic Potential, Drug Likeness Screening and Structure-Activity/Property Relationships of Thiazolidine-2, 4-Dione Derivatives. J. Bionanoscience 2016, 10, 118–126.
15. Juma J.M., Vuai S.A., Computational studies of the thermodynamic properties, and global and reactivity descriptors of fluorescein dye derivatives in acetonitrile using density functional theory, Journal of Chemical Research, 2021, 45:800
16. Belaidi, S.; Melkemi, N.; Bouzidi, D. Molecular geometry and structure-property relationships for 1, 2-dithiole-3-thione derivatives. Int. J. Chem. Res.
17. Yeşilkaynak T., Özkömeç F.N., Çeşme M., Demirdöğen R.E., Kutlu E., Kutlu H.M., Emen F.M., Synthesis of new thiourea derivatives and metal complexes: Thermal behavior, biological evaluation, in silico ADMET profiling and molecular docking studies, Journal of Molecular Structure, 2022, 1269:133758Fortune DG, Main CJ, O'Sullivan TM, Griffiths CE, Quality of life in patients with psoriasis: the contribution of clinical variables and psoriasis-specific stress, Br J Dermatol, 1997, 137:755-760.
Published
2025-01-17
How to Cite
Zina Saleh Hassan, Kadhim Zaid, A., & Ahmed.M.I. Alsanafi. (2025). Synthesis, Characterization, and DFT cucalutions, Biological Study of Five-membered Cyclic Containing the sulfur and nitrogen. Central Asian Journal of Medical and Natural Science, 6(1), 300-306. https://doi.org/10.17605/cajmns.v6i1.2698
Section
Articles
Copyright (c) 2025 Auhood Kadhim Zaid, Zina Saleh Hassan, Ahmed.M.I. Alsanafi
This work is licensed under a Creative Commons Attribution 4.0 International License.
