Antibacterial activity of ferulic acid extracted from corn bran (Zea mays L) against dental decay causing Lactobacillus spp.
Keywords:
Ferulic acid, corn bran, Lactobacillus spp.
Abstract
One of the main causes of dental caries in humans has been identified as lactobacilli. Numerous secondary metabolites, also known as phytochemicals, are produced by plants and are known to play a part in defense mechanisms.Most of these metabolites are known to have antibacterial qualities and other positive health impacts. Using 1 M sodium hydroxide, ferulic acid was extracted from corn bran. Higher amounts of ferulic acid were purified for 12 hours using a methanol solvent. The FT-IR spectrum and HPLC analysis were used to describe the purification of ferulic acid. The contents of the products extracted under the experimental circumstances varied. Dental caries was primarily caused by L. fermentum. High bactericidal effectiveness against all Lactobacillus species was demonstrated by ferulic acid. The L. fermentum showed minimal MIC levels with higher activity. This promoted the usage of corn bran's ferulic acid as an additive in the most widely used mouth paste.
References
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Aarabi, A.; Honarvar, M.; Mizani, M.; Faghihian, H. And Gerami, A. (2016). Extraction And Purification Of Ferulic Acid As An Antioxidant From Sugar Beet Pulp By Alkaline Hydrolysis Ital. J. Food Sci., 28: 362.
Donkoh, E.; Degenstein, J.; Tucker, M. and Ji, Y. (2012). Optimization of anzymatic hydrolysis of dilute acid pretreated sugar beet pulp using response surface design. Journal of Sugar Beet Research, 49 (1):13-16.
Smith, S.I.; Aweh, A.J.; Coker, A.O.; Savage, D.A. and Oyedeji, K.S. (2001). Lactobacilli in human dental caries and saliva. Microbios., 105 (411):77-85.
Pinheiro, P. G.; Santiago, G. Maria P.; da Silva, F. E.; Freitas2; de Araújo, A.C. et al. (2021). Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives. Asian Pacific Journal of Tropical Biomedicine 11(9): 405-413.
Song, W.; Xin, J.; Yu, C. and Pan, Y. (2023). Alkyl ferulic acid esters: Evaluating their structure and antibacterial properties. Frontiers in Microbiology, 14:1135308.
Pyrzynska, K. (2024). Ferulic Acid—A Brief Review of Its Extraction, Bioavailability and Biological Activity. Separations, 11(7):204.
Dędek, K.; Rosicka-Kaczmarek, J.; Nebesny, E. and Kowalska, G. (2019). Characteristics and biological properties of ferulic acid. Biotechnol. Food Sci., 83:71–85.
Zhai, Y.; Wang, T.; Fu, Y.; Yu, T.; Ding, Y. and Nie, H. (2023). Ferulic Acid: A Review of Pharmacology, Toxicology, and Therapeutic Effects on Pulmonary Diseases. Int. J. Mol. Sci., 24:8011.
Ye, L.; Hu, P.; Feng, L.P.; Huang, L.L.; Wang, Y.; Yan, X.; Xiong, J. and Xio, H.L.(2023). Protective Effects of Ferulic Acid on Metabolic Syndrome: A Comprehensive Review. Molecules, 28:281.
Dong, Q.; Tan, Y.; Tang, G.; Wu, Z.; Li, A.; Qin, X.; Li, S.; Liao, H.; Xiao, J. and Huang, Q. (2023). Neuroprotective potentials of ferulic acid against intracerebral hemorrhage COVID-19 through using network pharmacology approach and molecular docking analysis. Curr. Res. Toxicol., 5:100123.
Bao, X.; Li, W.; Jia, R.; Meng, D.; Zhang, H. and Xia, L.(2023). Molecular mechanism of ferulic acid and its derivatives in tumor progression. Pharmacol. Rep., 75: 891–906.
Ishtiaq, I.; Zeb, A.; Badshah, H.; Alattar, A.; Alshaman, R. and Koh, P.O. (2023). Enhanced cardioprotective activity of ferulic acid-loaded solid lipid nanoparticle in an animal model of myocardial injury. Toxicol. Appl. Pharmacol., 476: 116657.
Alam, M.A. (2019). Anti-hypertensive Effect of Cereal Antioxidant Ferulic Acid and Its Mechanism of Action. Front. Nutr., 6:121.
Wang, Y.; Chen, X.; Huang, Z.; Chen, D.; Yu, B. and Yu, J. (2020). Dietary ferulic acid supplementation improves antioxidant capacity and lipid metabolism in weaned piglets. Nutrients, 12:3811.
Raj, N.D. and Singh, D.(2022). A critical appraisal on ferulic acid: Biological profile, biopharmaceutical challenges and nano formulations. Health Sci. Rev., 5: 100063.
Luziatelli, F.; Brunetti, L.; Ficca, A.G. and Ruzzi, M.(2019). Maximizing the Efficiency of Vanillin Production by Biocatalyst Enhancement and Process Optimization. Front. Bioeng. Biotechnol., 7: 279.
Caufield, P.W.; Schön, C.N.; Saraithong, P.; Li, Y. and Argimón, S.(2015). Oral Lactobacilli and dental caries: a model for niche adaptation in humans. J Dent Res.;94:110S–8S.
Wen, Z.T.; Huang, X.; Ellepola, K.; Liao, S. and Li, Y.(2022). Lactobacilli and human dental caries: more than mechanical retention. Microbiology, 168(6): 001196.
Caufield, P.W.; Schön, C.N.; Saraithong, P.; Li, Y. and Argimón, S.(2015). Oral Lactobacilli and Dental Caries: A Model for Niche Adaptation in Humans. J Dent Res.; 94 (9 Suppl):110S-8S.
Stavova, E.; Porizka,J.; Stursa, V.; Enev,V. and Divis, P. (2017). Extraction Of Ferulic Acid From Wheat Bran By Alkaline Hydrolysis. Brno, Czech Republic. 575.580.
Aarabi, A.; Mizani, M.; Honarvar, M.; Faghihian, H. and Gerami, A. (2016). Extraction of ferulic acid from sugar beet pulp by alkaline hydrolysis and organic solvent methods. Food Measure, 10:42–47.
Ideia, P.; Sousa-Ferreira, I.; and Castilho, P. C. (2020). A Novel and Simpler Alkaline Hydrolysis Methodology for Extraction of Ferulic Acid from Brewer’s Spent Grain and its (Partial) Purification through Adsorption in a Synthetic Resin. Foods, 9 (600):1-13.
Borges, A.; Ferreira, C.; Saavedra, M.J. and Simões, M.(2013). Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria. Microb Drug Resist.; 19(4): 256-65.
Al-Anbakey, Y.H.A., Muslim, S.N., Hamzah, I.H. (2024). Screening and Optimization of Dextransucrase Production from Lactobacillus acidophilus. Advancements in Life Sciences, 11(1):130–135.
Bauer, J.L.; Harbaum-Piayda, B. and Schwarz, K.(2012). Phenolic compounds from hydrolyzed and extracted fiber-rich by products. LWT - Food Science and Technology 47:246-254.
Aarabi, A.; Honarvar, M.; Mizani, M.; Faghihian, H. And Gerami, A. (2016). Extraction And Purification Of Ferulic Acid As An Antioxidant From Sugar Beet Pulp By Alkaline Hydrolysis Ital. J. Food Sci., 28: 362.
Donkoh, E.; Degenstein, J.; Tucker, M. and Ji, Y. (2012). Optimization of anzymatic hydrolysis of dilute acid pretreated sugar beet pulp using response surface design. Journal of Sugar Beet Research, 49 (1):13-16.
Smith, S.I.; Aweh, A.J.; Coker, A.O.; Savage, D.A. and Oyedeji, K.S. (2001). Lactobacilli in human dental caries and saliva. Microbios., 105 (411):77-85.
Pinheiro, P. G.; Santiago, G. Maria P.; da Silva, F. E.; Freitas2; de Araújo, A.C. et al. (2021). Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives. Asian Pacific Journal of Tropical Biomedicine 11(9): 405-413.
Song, W.; Xin, J.; Yu, C. and Pan, Y. (2023). Alkyl ferulic acid esters: Evaluating their structure and antibacterial properties. Frontiers in Microbiology, 14:1135308.
Published
2025-01-08
How to Cite
Hala M.Sabre. (2025). Antibacterial activity of ferulic acid extracted from corn bran (Zea mays L) against dental decay causing Lactobacillus spp. Central Asian Journal of Medical and Natural Science, 6(1), 270-277. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2694
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Articles
