On The Development Of The Technology For "Prostad" Capsules Based On Natural Origin Substances
Keywords:
Phytotherapeutic, Capsule, Biologically, Moisture-Absorbing, Granulated, Dry Extract, Compressibility, Pressability, Gravimetric Method
Abstract
A promising direction in this field is the development of new preparations based on herbal medicines, such as narrow-leaved fireweed (Epilobium angustifolium). In light of the above, the search for and implementation of new, highly effective encapsulated plant-based medicinal forms is of particular interest. At the Department of Industrial Pharmaceutical Technology of the Tashkent Pharmaceutical Institute, studies are being conducted to explore the potential of extracting biologically active substances from narrow-leaved fireweed (Epilobium angustifolium) in the form of an extract, with the aim of developing an encapsulated medicinal form for the treatment of prostatitis and prostate adenoma. The article presents the results of a comparative study on the technological parameters and hygroscopicity of the dry extract and the encapsulated mass of "Prostad." During the experiments, the following technological characteristics of the dry extract were studied: moisture content, bulk density, angle of repose, and flowability coefficient. Additionally, the loss on drying, heavy metal content, and microbiological purity were determined using methods described in the literature and regulatory documentation.
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Ilhamova N.B., Djalilov Kh.K., Yunusova Kh.M. Research on the development of fast-dissolving tablets with expectorant and mucolytic effects // Pharmaceutical Journal. - Tashkent.- 2017.-№1.-P.53-57.
Ravshanova S.E., Yunusova Kh.M. Evaluation of biopharmaceutical and pharmacological properties of combined ternary componential analgesic tablets // International Journal of Psychosocial Rehabilitation.-United Kingdom.-2020.-Vol. 24.-Issue 02.-P.6009-6017.
Yunusova Kh.M., Abdijalilova Z.H. "Research On The Choice Of 'Ambronat' Syrup Technology" // The American Journal of Medical Sciences and Pharmaceutical Research, February 13, Vol. 03, Issue 02-01, 2021.-P. 1-9.
Yunusova Kh.M., Abdijalilova Z.H. "Research on the Selection of a Certain Content of 'Ambronat' Juice Syrup" // International Journal of Pharmacy and Pharmaceutical Research, Vol.:20, Issue:4, 2021.-P.62-71.
Yunusova Kh.M., Jaloliddinova M.Sh. Biopharmaceutical aspects of capsulirine drug based on NSAIDs // International Journal of Psychosocial Rehabilitation.-Vol. 24, Issue 04, 2020.-P.2258-2265.
N.B. Ilkhamova, Z.A. Nazarova, Kh.M. Yunusova. "Studying the effect of relative humidity and compaction pressure on the quality of tablets and pressed mass" // World Journal of Pharmacy and Pharmaceutical Sciences.-2019.-Vol. 8.-Issue 6.-P. 35-40.
N.N. Sherkhadjayeva, Kh.M. Yunusova, N.B. Ilkhamova. "On the choice of the composition of soluble tablets with licorice extract" // World Journal of Pharmacy and Pharmaceutical Sciences.-2019.-Vol. 8.-Issue 6.-P. 41-47.
Ravshanova S.E., Yunusova Kh.M. Evaluation of biopharmaceutical and pharmacological properties of combined ternary componential analgesic tablets // International Journal of Psychosocial Rehabilitation.-United Kingdom.-2020.-Vol. 24.-Issue 02.-P.6009-6017.
Yunusova Kh.M., Jaloliddinova M.Sh. Studying pharmacotechnological aspects and stability of “Ortof-S” tablets // World Journal of Pharmacy and Pharmaceutical Sciences.-2019.-Vol. 8.-Issue 1.-P. 277-288.
Kachalina T.V. Development of technology for obtaining solid dosage forms containing plant extracts: Dissertation Abstract, Candidate of Pharmaceutical Sciences / T.V. Kachalina.-Moscow, 2005.-26 p.
Larry L. Augsburger, Stephen W. Hoag. Pharmaceutical dosage forms: Tablets.- Informa Health Care, 2008.-568 p.
Cox D.C., Druglas W.B. et al. Guidance for dissolution testing // Pharm Technol. – 2008. – Vol. 4.- №1. – P.78-90.
Samedinova D.N., Yunusova Kh.M. Studying quality indicators of metoclopramide tablets prepared by wet granulation // Pharmacy.-Moscow.-2020.-P.211-213.
Yunusova Kh.M., Samedinova D.N. Analysis of the volume and cost of import of metoclopramide tablets in the Republic of Uzbekistan // EPRA International Journal of Multidisciplinary Research.-2021.-Vol. 7, Issue 1.-P. 97–102.
Tursunova M.Kh., Yunusova Kh.M., Samedinova D.N. Preclinical studies of acute toxicity and antiemetic activity of metoclopramide preparation // Infection, Immunity, and Pharmacology.-2021.-№6.-P.177-182.
Samedinova D.N., Yunusova Kh.M. Marketing analysis of antiemetic drugs in the pharmaceutical market of Uzbekistan // Pharmaceutical Journal.-2022.-№2.-P.6-14.
Yunusova Kh.M., Samedinova D.N. “Cerumax” and “Cerumax Forte” tablets and their pressed mass moisture absorption kinetics // Uzbekistan Pharmaceutical Bulletin.-2022.-№2.-P.24-28.
Yunusova Kh.M., Samedinova D.N. Investigation on the Study of the Biopharmaceutical Efficiency of the Recommended Tablets "Cerumax Forte" // International Journal of Development and Public Policy.-2022.-Vol.2.-Issue 9.-P.6–9.
Yunusova Kh.M., Sherkhadjayeva N.N. Evaluation of the moisture absorption kinetics of licorice dry extract depending on various factors // Pharmaceutical Journal.-Tashkent.-2019.-№3.-P.83-87.
Yunusova Kh.M., Sherkhadjayeva N.N. Factors affecting the gas-forming properties of a new combined fast-dissolving cough medicine // Pharmacy.-St. Petersburg.-2020.-P.630-631.
Yunusova Kh.M., Sherkhadjayeva N.N. Selection of the optimal composition of granules “Mukhas Forte.”
Yunusova Kh.M., Sherkhadjayeva N.N. Study of the hygroscopicity of the recommended granulated dosage forms “Mukhas Forte.”
Yunusova Kh.M., Sherkhadjayeva N.N. Mucolytic activity of the proposed drugs “Mukhas Forte.”
Yunusova K. M., Abdijalilova Z.Kh., Zaynutdinov K.S. The Peculiarities of Studies on the Stability of Ambronat // International Journal of Current Science Research and Review ISSN: 2581-8341 Volume 07 Issue 02 February 2024 DOI: 10.47191/ijcsrr/V7-i2-18, Impact Factor: 7.943. P.1043-1049.
Published
2024-12-18
How to Cite
Kh.M. Yunusova, Sh.Kh. Sunnatov, M.Sh. Jaloliddinova, & F.Zh. Anvarova. (2024). On The Development Of The Technology For "Prostad" Capsules Based On Natural Origin Substances. Central Asian Journal of Medical and Natural Science, 6(1), 161-168. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2683
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Articles
