Study Of Quality Indicators Of Tablets "Enformin" and "Sitmet" With Antidiabetic Effect

Abstract

This study evaluates the quality indicators of two antidiabetic tablet formulations, "Enformin" and "Sitmet," focusing on their technological properties and compliance with pharmacopoeial standards. The research aimed to identify compositions that optimize tablet quality through the addition of auxiliary substances. Five compositions for each tablet were analyzed for properties such as hardness, friability, dissolution rate, and moisture absorption. Rigidity and disintegration tests revealed that "Enformin" composition ET-3 and "Sitmet" composition ST-5 consistently met or exceeded quality standards. Moisture absorption studies confirmed low hygroscopicity for both formulations, while residual moisture and compression pressure studies established optimal manufacturing parameters for producing high-quality tablets. Results indicate that specific compositions and manufacturing conditions directly influence the physicochemical properties, ensuring tablet stability and efficacy. These findings provide a basis for scaling up production to meet growing local demands for antidiabetic drugs, in alignment with Uzbekistan's pharmaceutical development goals.