Estimation of Serum Level of Neurokinin A in Patients with Periodontitis in Association with Chronic Migraine Disease (Observational Case Control Study)

Zaid Shakir  Abed; Hayder Fadhil  Lateef; Ali Saleh  Hatem; Husam Abdulabbas  Mutashar; Murtatha Mohammed  Al-Anezi; Zain Alabdeen Abdul Abbas  Noaman

Zaid Shakir Abed Department of Dentistry, Kut University College, 52001, Wasit, Iraq
Hayder Fadhil Lateef Ministry of Health, Al-Zahraa Teaching Hospital, Wasit, Iraq
Ali Saleh Hatem Department of Dentistry, Kut University College, 52001, Wasit, Iraq
Husam Abdulabbas Mutashar Department of Dentistry, Kut University College, 52001, Wasit, Iraq
Murtatha Mohammed Al-Anezi Department of Dentistry, Kut University College, 52001, Wasit, Iraq
Zain Alabdeen Abdul Abbas Noaman Department of Dentistry, Kut University College, 52001, Wasit, Iraq

Keywords: Periodontitis, Chronic Migraine, Neurokinin A (NKA), Neuropeptides, BOP

Abstract

Recently, a relationship was found between periodontitis and chronic migraine. However, there is no evidence of the association between periodontitis and Neurokinin A (NKA) level in chronic migraine patients. As a result, we aimed to measure and compare serum levels of NKA in study and control groups in order to determine whether periodontitis is associated with chronic mi-graine disease activation. Eightytwo (82) males and females above the age of 18 were recruited. Subjects were divided into four groups: 27 patients with chronic migraine and periodontitis, 27 patients with chronic migraine and clinically healthy periodontium, 20 patients systemically healthy with periodontitis and eight subjects with clinically healthy periodontium and without any systemic disease. Assessment of periodontal status was carried out for all participants. Socio demographic data and comorbidities were assessed by means of a standard questionnaire then blood samples were collected and serum concentrations were separated for NKA. The serum level of NKA were higher in the control group (38±40) and there was a significant difference between the other groups when compared to the control group (P=0.003) and there was a weak negative significant correlation between neurokinin A and clinical periodontal parameters (BOP, Cal, and PPD) between all study groups. According to the findings of this study, the control group had a higher level of serum NKA. As a result, this peptide could be considered an indicator of disease severity and activity for both periodontitis and chronic migraine diseases. So far, no research has backed up our findings. Longitudinal studies are required to validate our findings.

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