In Vitro Evaluation Of Curcumin and Its Analogues (1-6) Against The MDA MB-231 Breast Cancer Cell Lines
Keywords:
Brest Cancer; Curcumin; MDA-MB-231cell Line; Selectivity Index; MTT Method
Abstract
Our previous work included the synthesis and identification of curcumin and its analogues (1-6). This study involved in vitro evaluation of curcumin and its analogues (1-6) as anti-breast cancer against MDA-MB 231cell line. Curcumin and all analogues (1-6) were assayed in vitro as anti-proliferation against the MDA-MB-231 breast cancer cell line by using the Micro-Culture Tetrazolium (MTT) method. Compound 6 (IC50 99.36 and SI 2.5) exhibited strong cytotoxic activity and selectivity than curcumin and compounds (1-5). This makes it a more promising selective agent for treating triple-negative breast cancer cell lines (TNBC) than other compounds 1–5
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Changavi AA, Shashikala A, Ramji AS. Epidermal growth factor receptor expression in triple negative and nontriple negative breast carcinomas. Journal of laboratory physicians. 2015;7(02):079-83.
Shilpi S, Shivvedi R, Khatri K. Triple Negative Breast Cancer (TNBC): A challenge for current cancer therapy. J Hum Virol Retrovirol. 2018;6:00189.
Qiu J, Xue X, Hu C, Xu H, Kou D, Li R, et al. Comparison of clinicopathological features and prognosis in triple-negative and non-triple negative breast cancer. Journal of cancer. 2016;7(2):167.
Ocana A, Pandiella A. Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies. Oncotarget. 2017;8(13):22218.
Kirouac DC, Du J, Lahdenranta J, Onsum MD, Nielsen UB, Schoeberl B, et al. HER2+ cancer cell dependence on PI3K vs. MAPK signaling axes is determined by expression of EGFR, ERBB3 and CDKN1B. PLoS computational biology. 2016;12(4):e1004827.
Thakur V, Kutty RV. Recent advances in nanotheranostics for triple negative breast cancer treatment. Journal of Experimental & Clinical Cancer Research. 2019;38(1):430.
Alsaad H, Kubba A, Tahtamouni LH, Hamzah AH. Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3-dimethyl aminobenzoic acid) moiety. Pharmacia. 2022;69:415-28.
Segovia-Mendoza M, Romero-Garcia S, Lemini C, Prado-Garcia H. Determining Factors in the Therapeutic Success of Checkpoint Immunotherapies against PD‐L1 in Breast Cancer: A Focus on Epithelial‐Mesenchymal Transition Activation. Journal of Immunology Research. 2021;2021(1):6668573.
Zhao L, Zhou S, Gustafsson J-Å. Nuclear receptors: recent drug discovery for cancer therapies. Endocrine reviews. 2019;40(5):1207-49.
Pan S-Y, Zhou S-F, Gao S-H, Yu Z-L, Zhang S-F, Tang M-K, et al. New perspectives on how to discover drugs from herbal medicines: CAM′ S outstanding contribution to modern therapeutics. Evidence‐Based Complementary and Alternative Medicine. 2013;2013(1):627375.
Kapinova A, Stefanicka P, Kubatka P, Zubor P, Uramova S, Kello M, et al. Are plant-based functional foods better choice against cancer than single phytochemicals? A critical review of current breast cancer research. Biomedicine & Pharmacotherapy. 2017;96:1465-77.
Kapinova A, Kubatka P, Golubnitschaja O, Kello M, Zubor P, Solar P, et al. Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention. Environmental health and preventive medicine. 2018;23:1-18.
Badran HA, Al-Maliki A, Alfahed RF, Saeed BA, Al-Ahmad A, Al-Saymari F, et al. Synthesis, surface profile, nonlinear reflective index and photophysical properties of curcumin compound. Journal of Materials Science: Materials in Electronics. 2018;29:10890-903.
Huang Y, Jiang X, Liang X, Jiang G. Molecular and cellular mechanisms of castration resistant prostate cancer. Oncology letters. 2018;15(5):6063-76.
Abd. Wahab NA, H. Lajis N, Abas F, Othman I, Naidu R. Mechanism of anti-cancer activity of curcumin on androgen-dependent and androgen-independent prostate cancer. Nutrients. 2020;12(3):679.
Phansalkar PS, Zhang Z, Verenich S, Gerk PM. Pharmacokinetics and bioavailability enhancement of natural products. Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. 2020:109-41.
Chainoglou E, Hadjipavlou-Litina D. Curcumin in health and diseases: Alzheimer’s disease and curcumin analogues, derivatives, and hybrids. International journal of molecular sciences. 2020;21(6):1975.
Sethi S, Choudhary S, Sharma D, Jyothi VGS, Baldi A, Madan NKMJ. Armamentarium of anticancer analogues of curcumin: Portray of structural insight, bioavailability, drug-target interaction and therapeutic efficacy. Journal of Molecular Structure. 2021;1231:129691.
Panda SS, Girgis AS, Thomas SJ, Capito JE, George RF, Salman A, et al. Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates. European Journal of Medicinal Chemistry. 2020;196:112293.
Jaafar ND, Al-Saffar AZ, Yousif EA. Genotoxic and cytotoxic activities of lantadene A-loaded gold nanoparticles (LA-AuNPS) in MCF-7 cell line: an in vitro assessment. International journal of toxicology. 2020;39(5):422-32.
Mahmood RI, Abbass AK, Al-Saffar AZ, Al-Obaidi JR. An in vitro cytotoxicity of a novel pH-Sensitive lectin loaded-cockle shell-derived calcium carbonate nanoparticles against MCF-7 breast tumour cell. Journal of Drug Delivery Science and Technology. 2021;61:102230.
Ali Z. Al-Saffar, Fatimah A. Sabry, Shymaa L. Al-Brazanchi, Ahmed F. Al-Shanon, Firas Hassan and Noora A. Hadi. Phytochemical analysis, antioxidant and cytotoxic potentials of Pelargonium graveolens extract in human breast adenocarcinoma (MCF-7) cell line Asian J Biochem. 2017;12:16-26.
Jihad RS, Abdul-Rida NA, Al-Shamari AM, Al-Masoudi NA, Saeed BA. Design, synthesis, and in-silico study of new letrozole derivatives as prospective anticancer and antioxidant agents. Zeitschrift für Naturforschung B. 2023;78(6):343-53.
Weerapreeyakul N, Nonpunya A, Barusrux S, Thitimetharoch T, Sripanidkulchai B. Evaluation of the anticancer potential of six herbs against a hepatoma cell line. Chinese medicine. 2012;7:1-7.
Bastos PM, Eriksson J, Green N, Bergman Å. A standardized method for assessment of oxidative transformations of brominated phenols in water. Chemosphere. 2008;70(7):1196-202.
Zhao C, Liu Z, Liang G. Promising curcumin-based drug design: mono-carbonyl analogues of curcumin (MACs). Current pharmaceutical design. 2013;19(11):2114-35.
Gruber BM, Tomasz D, Adam K, Irena B. THE INFLUENCE OF POLYETHER SUBSTITUENTS ON BIOLOGICAL ACTIVITY OF CURCUMIN DERIVATIVES. Acta Poloniae Pharmaceutica-Drug Research. 2020;77(1):99-111.
Published
2024-10-11
How to Cite
Imad khalaf Hassan, Rita S. Elis, & Shaker A.N Al-Jadaan. (2024). In Vitro Evaluation Of Curcumin and Its Analogues (1-6) Against The MDA MB-231 Breast Cancer Cell Lines. Central Asian Journal of Medical and Natural Science, 5(4), 1002-1009. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2652
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Articles
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