Three-Component Synthesis of Enaminones Based on Homoveratrilamine and Aromatic Aldehydes
Keywords:
three-component [1 2 1] synthesis, enaminone, and acetoacetic ester, homoveratrilamine.
Abstract
An efficient one-reactor procedure leading to β-enaminones has been developed. The developed methodology involves a multicomponent [1+2+1] cyclocondensation reaction of starting materials. As starting materials we used homoveratrilamine as the primary amine source and acetoacetic ether as the dicarbonyl compound and a number of aromatic aldehydes. Mild reaction conditions, simple and rapid methods of purification and separation of the obtained products further facilitated the synthesis process. The structure of the synthesized substances was established by IR, 1 H and 13C NMR spectra and physical constants were studied.
References
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Zhao Y. et al. Gold-catalyzed chemo-and diastereoselective C ( sp 2)–H functionalization of enaminones for the synthesis of pyrrolo [3, 4-c]-quinolin-1-one derivatives //Organic & Biomolecular Chemistry. – 2016. – T. 14. – №. 7. – C. 2177-2181.
Wan JP, Cao S., Liu Y. Base-promoted synthesis of N-substituted 1, 2, 3-triazoles via enaminone–azide cycloaddition involving Regitz diazo transfer //Organic letters. – 2016. – T. 18. – №. 23. – C. 6034-6037.
Quiñones RE et al. Direct synthesis of β - aminoenals through reaction of 1, 2, 3-triazine with secondary amines //Organic letters. – 2017. – T. 19. – №. 13. – C. 3568-3571.
Mart M., Trzeciak AM The synthesis of β -enaminones using trialkylamines and a Pd/DNA catalyst //Molecular Catalysis. – 2021. – T. 502. – C. 111365.
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Khudoiberdieva A. et al. - Synthesis of enaminones based on acetylacetone, homoveratrilamine and aromatic aldehydes // Universum. – 2024. – T. 2. – №. 6(120). – C. 40-45.
Published
2024-09-22
How to Cite
Abdumajitovna, K. A., Erkinovna, U. Z., Saidov Abdusalom Shomurodovich, & Ivanovna, V. V. (2024). Three-Component Synthesis of Enaminones Based on Homoveratrilamine and Aromatic Aldehydes. Central Asian Journal of Medical and Natural Science, 5(4), 876-880. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2625
Section
Articles
