Evaluating the Role of Interleukin IL-38 Level in Tonsillitis Patients and Relationship with Rheumatoid Arthritis in Diyala Province
Keywords:
Rheumatoid arthritis, IL-38, Tonsillitis, Autoimmune Disease, Biomarker
Abstract
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease linked to Streptococcus pyogenes infection, often initiated by tonsillitis or rheumatic fever. This study investigates the relationship between IL-38 levels and the presence of tonsillitis and RA. Conducted from October 2023 to May 2024 in Diyala Governorate, Iraq, 88 participants were categorized into four groups: RA patients, tonsillitis patients, patients with both conditions, and healthy controls. ELISA tests revealed significantly decreased IL-38 levels in RA (63.63 ± 14.45 Pg/ML), tonsillitis (46.97 ± 12.76 Pg/ML), and dual-condition patients (15.18 ± 5.64 Pg/ML) compared to controls (17.16 ± 10.66 Pg/ML). The study highlights IL-38's dual role in disease pathogenesis, suggesting its potential as a biomarker for RA and tonsillitis.
References
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[3] A. Diaz-Barreiro, A. Huard, and G. Palmer, "Multifaceted Roles of IL-38 in Inflammation and Cancer," Cytokine, vol. 151, p. 155808, 2022, doi: 10.1016/j.cyto.2022.155808.
[4] G. Y. Enas, "Study of Some Immunological Parameters in Patient That Infected with Streptococcus Pyogenes: Study of Some Immunological Parameters in Patient That Infected with Streptococcus Pyogenes," Iraqi Journal of Market Research and Consumer Protection, vol. 12, no. 1, pp. 128-132, 2020.
[5] E. G. Favalli, M. Biggioggero, C. Crotti, A. Becciolini, M. G. Raimondo, and P. L. Meroni, "Sex and Management of Rheumatoid Arthritis," Clinical Reviews in Allergy & Immunology, 2018, doi: 10.1007/s12016-018-8672-5.
[6] X. Gao, G. Wu, M. S. M. Tsang, D. Huang, C. W. K. Lam, and C. K. Wong, "Novel Insights into the Role of Anti-Inflammatory IL-38 in Immunity Against Infection," Cellular & Molecular Immunology, vol. 19, no. 11, pp. 1322-1324, 2022.
[7] K. Geißler, C. Weigel, K. Schubert, I. Rubio, and O. Guntinas-Lichius, "Cytokine Production in Patients with Recurrent Acute Tonsillitis: Analysis of Tonsil Samples and Blood," Scientific Reports, vol. 10, no. 1, p. 13006, 2020.
[8] S. B. Hassan, H. N. Abdullah, and K. Y. Zakair, "The Role of IL-37 as an Anti-Inflammatory Biomarker in Some Iraqi Rheumatoid Arthritis Patients and Its Correlation with DAS28," Journal of Techniques, vol. 4, Special Issue, pp. 123-127, 2022.
[9] A. W. Haidara, Y. Sidibé, D. Samaké, A. Coulibaly, M. K. Touré, B. B. Coulibaly, S. Soumaoro, B. Guindo, K. Diarra, K. Coulibaly, B. Sanogo, M. Kéïta, and A. A. Mohamed, "Tonsillitis and Their Complications," International Journal of Otorhinolaryngology and Head and Neck Surgery, vol. 8, no. 5, pp. 1205-1211, 2019.
[10] K. J. Brennan, A. Herbert, and E. Byrne, "IL-1 Family Members in Cancer: Two Sides to Every Story," Frontiers in Immunology, vol. 10, p. 1197, 2019, doi: 10.3389/fimmu.2019.01197.
[11] M. N. Khadilkar and N. R. Ankle, "Anaerobic Bacteriological Microbiota in Surface and Core of Tonsils in Chronic Tonsillitis," Journal of Clinical and Diagnostic Research, vol. 10, no. 11, pp. MC01-MC03, 2016.
[12] T. Kindt, R. Goldsby, and B. Osborne, "Rheumatoid Arthritis," in Kuby Immunology, 6th ed., New York, NY: W.H. Freeman and Company, 2007, pp. 401-421.
[13] J. Mora, A. Schlemmer, I. Wittig, F. Richter, M. Putyrski, A.-C. Frank, Y. Han, M. Jung, A. Ernst, A. Weigert, and B. Brüne, "Interleukin-38 is Released from Apoptotic Cells to Limit Inflammatory Macrophage Responses," Journal of Molecular Cell Biology, vol. 8, no. 5, pp. 426-438, Oct. 2016.
[14] F. F. Rija, S. Z. Hussein, and M. A. Abdalla, "Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients," Age (Year), vol. 18, no. 50, pp. 18-50, 2021.
Published
2024-09-04
How to Cite
Muhammad, R. Q., Abbas, A. F., & Hassan , I. B. (2024). Evaluating the Role of Interleukin IL-38 Level in Tonsillitis Patients and Relationship with Rheumatoid Arthritis in Diyala Province. Central Asian Journal of Medical and Natural Science, 5(4), 729-734. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2603
Section
Articles
This work is licensed under a Creative Commons Attribution 4.0 International License.
