Effect of Iron Overload on the  Liver Enzymes of Thalassemia Patients in Dhi Qar province

Riam Yousfe Muttair; Qammar Shaker Hmood; Rawa Abdulkareem Abd; Mohammed Jabbar  Mohammed; Muhammad Hakim Khuwaylid

Riam Yousfe Muttair Department of Biology, University of Thi-Qar
Qammar Shaker Hmood Department of Biology, University of Thi-Qar
Rawa Abdulkareem Abd Department of Biology, University of Thi-Qar
Mohammed Jabbar Mohammed Ministry of Education, Maysan Education Directorate
Muhammad Hakim Khuwaylid Department of Biology, University of Thi-Qar

Keywords: Thalassemia, Iron, Liver Enzymes, ALT, AST, ALP

Abstract

Hereditary hematologic diseases arise from hereditary factors that lead to disturbances in the balance of blood. The aim of this study was to assess the physiological characteristics of liver enzymes and investigate the impact of iron on these enzymes. For this investigation, a total of 150 blood samples were gathered. At the Thi-Qar Centre for Incendiary Disease in Nasiriyah City/Thi-Qar Province, fifty samples were taken from patients suffering from thalassemia, while twenty-five samples were taken from healthy individuals. Both the severity of the disease (thalassemia major and intermediate) and the gender of the patient are being taken into consideration while categorizing the patients into two groups. After receiving consent from the patients, samples were obtained between the months of January 2024 and February 2024. In this study, patients with thalassemia had substantially greater levels of ferritin, alanine transaminase, aspartate transaminase, and alkaline phosphatase compared to the control group. Liver enzyme levels did not differ significantly between thalassemia major and thalassemia intermediate, according to the study. In contrast, ferritin levels were much greater in thalassemia major than in thalassemia intermediate or minor. However, there was no statistically significant difference between the sexes when it came to ferritin and liver enzymes. Considering the study's conclusions , it was determined that the ferritin level brought about several difficulties and had a negative impact on the enzymes in the liver.

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