Study of the Relationship of Kim-1 Correlation with Some Physiological and Biochemical Indicators in Males with Diabetic Nephropathy in Kirkuk City

Rokan Hazim  Hamad; Sahib Jummah  Abdalrhman; Sadoon Mohammed  Abdullah

Rokan Hazim Hamad Ministry of Education, Director of Kirkuk Education, Kirkuk, Iraq
Sahib Jummah Abdalrhman Biology Department, Collage of Education for pure Sciences, University of Kirkuk, Kirkuk, Iraq
Sadoon Mohammed Abdullah Ministry of Education, Director of Kirkuk Education, Kirkuk, Iraq

Keywords: Diabetic nephropathy, HbA1C, Glucose-Insulin, Insulin resistance, Renal oxidative stress

Abstract

This study aimed to evaluate the relationship between KIM-1 protein and biochemical markers associated with diabetes, to determine its potential role as a biological indicator of the development of diabetic nephropathy. The study was conducted in Kirkuk Governorate during the period from December 2023 to May 2024, where 90 samples were collected from government and private hospitals and specialized medical clinics, including 70 patients with diabetic nephropathy and 20 non-diabetic nephropathy. Diabetic nephropathy is a chronic complication of diabetes, characterized by a gradual deterioration in kidney function due to damage to small blood vessels due to high blood glucose levels. The KIM-1 protein (known as Kidney Injury Molecule-1) is linked to kidney damage, as it is secreted from the cells of the renal tubules in response to damage, making it a potential indicator for monitoring the progress of kidney damage in people with diabetes. In this study, the KIM-1 levels were analyzed along with variables such as HBA1C, the level of cells in the blood, insulin level, and insulin resistance, using Pearson's connection coefficient. The results showed that there is a positive overwhelming connection between the KIM-1 and the levels of cake, HBA1C, and insulin resistance at the possibility of 0.000, as well as with the level of insulin at the possibility of 0.005. These results indicate that the Kim-1 may be a useful biological indicator to assess the progress of diabetic kidney disease, which calls for more research to explore its role in improving the diagnosis and control of the disease. The study aims to contribute to the development of better treatment and monitoring strategies for diabetic patients, with the aim of reducing the complications of the disease and improving the quality of health care provided to them.

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