Estimation Of Some Biochemical Parameters In Type -2 Diabetic Patients After Pfizer Vaccination Among Patients From Iraqi
Keywords:
Type 2 Diabetes Mellitus (T2DM), Myoglobin, Pfizer COVID-19 Vaccine, Lipid Profile, Kidney Function, Biochemical Markers.
Abstract
This study aimed to assess the changes in biochemical markers in type 2 diabetic patients after receiving the Pfizer COVID-19 vaccine. The research focused on measuring cardiac biochemical markers, specifically myoglobin and lipid profiles, as well as routine kidney function tests (blood urea and serum creatinine) following the second dose of the Pfizer vaccine. Myoglobin levels were estimated using an ELISA kit, while lipid profiles and renal function were determined using the Cobas analyzer. The results indicated higher myoglobin levels in both vaccinated and non-vaccinated diabetic groups compared to healthy controls. There were significant differences in lipid profiles between diabetic groups, although no significant differences were found between vaccinated and non-vaccinated groups. HDL levels were lower in both diabetic groups compared to healthy controls. The study found no significant adverse effects of the Pfizer vaccine on kidney function tests, with T2DM patients showing higher levels of myoglobin and lipid profiles but no significant difference between vaccinated and non-vaccinated individuals.
References
Cloete L. Diabetes mellitus: an overview of the types, symptoms, complications and management. Nursing Standard (Royal College of Nursing (Great Britain) : 1987), vol. 37, no. 1, 2022, pp. 61-6.
Kumar A, Arora A, Sharma P, Anikhindi SA, Bansal N, Singla V, et al. Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes & Metabolic Syndrome, vol. 14, no. 4, 2020, pp. 535-45.
Fox A, Norris C, Amanat F, Zolla-Pazner S, Powell RL. The vaccine-elicited immunoglobulin profile in milk after COVID-19 mRNA-based vaccination is IgG-dominant and lacks secretory antibodies. medRxiv, 2021.
Barda N, Dagan N, Ben-Shlomo Y, Kepten E, Waxman J, Ohana R, et al. Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting. The New England Journal of Medicine, vol. 385, no. 12, 2021, pp. 1078-90.
Hendgen-Cotta UB, Esfeld S, Coman C, Ahrends R, Klein-Hitpass L, Flögel U, et al. A novel physiological role for cardiac myoglobin in lipid metabolism. Scientific Reports, vol. 7, no. 1, 2017, p. 43219.
Ahmed AM, Khabour OF, Awadalla AH, Waggiallah HA. Serum trace elements in insulin-dependent and non-insulin-dependent diabetes: a comparative study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 11, 2018, pp. 887-92.
Chutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. National Journal of Physiology, Pharmacy and Pharmacology, vol. 7, no. 9, 2017, pp. 914-9.
Hasanato RM. Trace elements in type 2 diabetes mellitus and their association with glycemic control. African Health Sciences, vol. 20, no. 1, 2020, pp. 287-93.
Sen S, Bose T, Roy A, Chakraborti AS. Effect of non-enzymatic glycation on esterase activities of hemoglobin and myoglobin. Molecular and Cellular Biochemistry, vol. 301, no. 1-2, 2007, pp. 251-7.
Nye NS, Kasper K, Madsen CM, Szczepanik M, Covey CJ, Oh R, et al. Clinical Practice Guidelines for Exertional Rhabdomyolysis: A Military Medicine Perspective. Current Sports Medicine Reports, vol. 20, no. 3, 2021, pp. 169-78.
Simonen PP, Gylling HK, Miettinen TA. Diabetes contributes to cholesterol metabolism regardless of obesity. Diabetes Care, vol. 25, no. 9, 2002, pp. 1511-5.
Parcero-Valdés JJ. Dislipidemia diabética. Cardiovascular and Metabolic Science, vol. 32, no. S3, 2021, pp. 168-72.
Vergès B. Pathophysiology of diabetic dyslipidaemia: where are we? Diabetologia, vol. 58, no. 5, 2015, pp. 886-99.
Klimek L, Novak N, Hamelmann E, Werfel T, Wagenmann M, Taube C, et al. Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA: Position statement of the German Allergy Societies: Medical Association of German Allergologists (AeDA), German Society for Allergology and Clinical Immunology (DGAKI) and Society for Pediatric Allergology and Environmental Medicine (GPA). Allergo Journal International, vol. 30, no. 2, 2021, pp. 51-5.
Thapa SD, KC SR, Gautam S, Gyawali D. Dyslipidemia in type 2 diabetes mellitus. Journal of Pathology of Nepal, vol. 7, no. 2, 2017, pp. 1149-54.
Edgerton DS, Kraft G, Smith M, Farmer B, Williams PE, Coate KC, et al. Insulin’s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion. JCI Insight, vol. 2, no. 6, 2017.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, et al. Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities. International Journal of Molecular Sciences, vol. 21, no. 7, 2020.
Perseghin G, Scifo P, De Cobelli F, Pagliato E, Battezzati A, Arcelloni C, et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes, vol. 48, no. 8, 1999, pp. 1600-6.
Cheung B, Hwang J, Stolarczyk A, Mahlof EN, Block RC. Case study of hypertriglyceridemia from COVID-19 Pfizer-BioNTech vaccination in a patient with familial hypercholesteremia. European Review for Medical and Pharmacological Sciences, vol. 25, no. 17, 2021, pp. 5525-8.
Jacobs MJ, Kleisli T, Pio JR, Malik S, L'Italien GJ, Chen RS, et al. Prevalence and control of dyslipidemia among persons with diabetes in the United States. Diabetes Research and Clinical Practice, vol. 70, no. 3, 2005, pp. 263-9.
Adiels M, Olofsson SO, Taskinen MR, Borén J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 7, 2008, pp. 1225-36.
Srivastava RAK. Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease. Molecular and Cellular Biochemistry, vol. 440, no. 1-2, 2018, pp. 167-87.
Kaysen G. Dyslipidemia in chronic kidney disease: Causes and consequences. Kidney International, vol. 70, 2006, pp. S55-S8.
Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care, vol. 27, no. 6, 2004, pp. 1496-504.
Kumar A, Arora A, Sharma P, Anikhindi SA, Bansal N, Singla V, et al. Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes & Metabolic Syndrome, vol. 14, no. 4, 2020, pp. 535-45.
Fox A, Norris C, Amanat F, Zolla-Pazner S, Powell RL. The vaccine-elicited immunoglobulin profile in milk after COVID-19 mRNA-based vaccination is IgG-dominant and lacks secretory antibodies. medRxiv, 2021.
Barda N, Dagan N, Ben-Shlomo Y, Kepten E, Waxman J, Ohana R, et al. Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting. The New England Journal of Medicine, vol. 385, no. 12, 2021, pp. 1078-90.
Hendgen-Cotta UB, Esfeld S, Coman C, Ahrends R, Klein-Hitpass L, Flögel U, et al. A novel physiological role for cardiac myoglobin in lipid metabolism. Scientific Reports, vol. 7, no. 1, 2017, p. 43219.
Ahmed AM, Khabour OF, Awadalla AH, Waggiallah HA. Serum trace elements in insulin-dependent and non-insulin-dependent diabetes: a comparative study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 11, 2018, pp. 887-92.
Chutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. National Journal of Physiology, Pharmacy and Pharmacology, vol. 7, no. 9, 2017, pp. 914-9.
Hasanato RM. Trace elements in type 2 diabetes mellitus and their association with glycemic control. African Health Sciences, vol. 20, no. 1, 2020, pp. 287-93.
Sen S, Bose T, Roy A, Chakraborti AS. Effect of non-enzymatic glycation on esterase activities of hemoglobin and myoglobin. Molecular and Cellular Biochemistry, vol. 301, no. 1-2, 2007, pp. 251-7.
Nye NS, Kasper K, Madsen CM, Szczepanik M, Covey CJ, Oh R, et al. Clinical Practice Guidelines for Exertional Rhabdomyolysis: A Military Medicine Perspective. Current Sports Medicine Reports, vol. 20, no. 3, 2021, pp. 169-78.
Simonen PP, Gylling HK, Miettinen TA. Diabetes contributes to cholesterol metabolism regardless of obesity. Diabetes Care, vol. 25, no. 9, 2002, pp. 1511-5.
Parcero-Valdés JJ. Dislipidemia diabética. Cardiovascular and Metabolic Science, vol. 32, no. S3, 2021, pp. 168-72.
Vergès B. Pathophysiology of diabetic dyslipidaemia: where are we? Diabetologia, vol. 58, no. 5, 2015, pp. 886-99.
Klimek L, Novak N, Hamelmann E, Werfel T, Wagenmann M, Taube C, et al. Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA: Position statement of the German Allergy Societies: Medical Association of German Allergologists (AeDA), German Society for Allergology and Clinical Immunology (DGAKI) and Society for Pediatric Allergology and Environmental Medicine (GPA). Allergo Journal International, vol. 30, no. 2, 2021, pp. 51-5.
Thapa SD, KC SR, Gautam S, Gyawali D. Dyslipidemia in type 2 diabetes mellitus. Journal of Pathology of Nepal, vol. 7, no. 2, 2017, pp. 1149-54.
Edgerton DS, Kraft G, Smith M, Farmer B, Williams PE, Coate KC, et al. Insulin’s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion. JCI Insight, vol. 2, no. 6, 2017.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, et al. Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities. International Journal of Molecular Sciences, vol. 21, no. 7, 2020.
Perseghin G, Scifo P, De Cobelli F, Pagliato E, Battezzati A, Arcelloni C, et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes, vol. 48, no. 8, 1999, pp. 1600-6.
Cheung B, Hwang J, Stolarczyk A, Mahlof EN, Block RC. Case study of hypertriglyceridemia from COVID-19 Pfizer-BioNTech vaccination in a patient with familial hypercholesteremia. European Review for Medical and Pharmacological Sciences, vol. 25, no. 17, 2021, pp. 5525-8.
Jacobs MJ, Kleisli T, Pio JR, Malik S, L'Italien GJ, Chen RS, et al. Prevalence and control of dyslipidemia among persons with diabetes in the United States. Diabetes Research and Clinical Practice, vol. 70, no. 3, 2005, pp. 263-9.
Adiels M, Olofsson SO, Taskinen MR, Borén J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 7, 2008, pp. 1225-36.
Srivastava RAK. Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease. Molecular and Cellular Biochemistry, vol. 440, no. 1-2, 2018, pp. 167-87.
Kaysen G. Dyslipidemia in chronic kidney disease: Causes and consequences. Kidney International, vol. 70, 2006, pp. S55-S8.
Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care, vol. 27, no. 6, 2004, pp. 1496-504.
Published
2024-08-02
How to Cite
Shrooq A. Hussein. (2024). Estimation Of Some Biochemical Parameters In Type -2 Diabetic Patients After Pfizer Vaccination Among Patients From Iraqi. Central Asian Journal of Medical and Natural Science, 5(4), 327-337. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2555
Section
Articles
