Hemostatic Nanobiocomposite Based on the Base Cellulose Derivatives
Keywords:
oxycellulose, nanocellulose, sodium H carboxymethylcellulose, composite, hemostatic agent, IR spectroscopy, carboxymethyl and carboxylate functional groups.
Abstract
A method has been developed for producing a composite biodegradable hemostatic agent in the form of films based on sodium H carboxymethylcellulose (Na-H-CMC), oxycellulose (OC), nanocellulose (NC) and chemically bound calcium ions. The contents of the components in the hemostatic agent, in terms of dry matter, were 55% for Na-H-CMC 30% for OC, 4% for NC and 11% for calcium chloride. Biodegradable films 100 µm thick were obtained; their hemostatic time was 34 ± 2 s. Studies were carried out to determine acute and chronic toxicity and hematological and biochemical parameters of the blood of experimental animals. Based on these research results, the possibility of using hemostatic compositions in practical medicine has been established.
References
1. Belova A.V., Yudanova T.N., Galbraikh L.S. Preparation of biologically active cellulose fibers modified by treatment with xybethene-cel. Chemistry of plant materials. 2010. №4. pp. 11–15.
2. Budko E. V., Chernikova D. A., Yampolsky L. M., Yatsyuk V. Ya. Local hemostatic agents and ways to improve them. Russian Medical and Biological Bulletin named after Academician I.P. Pavlova. 2019. V. 27. №2. pp. 274-285.
3. Treskova V. I., Shipina O. T., Romanova S. M., Nikitin V. G. Chemical modification of carboxymethylcellulose with diaminofurazan. Bulletin of the Technological University. 2016. V.19, №12 P. 172-175.
4. Sarymsakov А.А., Yunusov KhE. Preparation and properties of antistatic hydrogel "Aspike". Pharmaceutical journal. 2015. № 3. pp. 60-65.
5. Grigoriev I.A., Morozov S.V., Tkacheva N.I., Pankrushina N.A., Chernyavsky A.M., Tarkova A.R. A method for producing a hemostatic agent based on oxidized cellulose using microwave exposure. Published: 09/20/2015. Bull. № 26.
6. Lipatov V.A., Severinov D.A., Saakyan A.R. Local applicational blood reestablishing instruments in surgery of the XXI century (literary review). Innova. 2019;(1):16-22.
7. Tarkova A.R. The effectiveness of various forms of local hemostatic materials based on oxidized cellulose in the experiment “Bulletin of Surgery named after. I.I. Grekova." - 2015. -V. 174. - № 6. - P. 56-60.
8. Bicer A.S. Bayram, O. Gurbuz et al. Assessment of the efficacy of bioabsorbable oxidized regenerated cellulose for prevention of post-operative pericardial adhesion in the rabbit model. J. Int. Med. Res. - 2008. № 36. - P. 1311-1318.
9. Lipatov V.A., Lazarenko S.V., Severinov D.A., Saakyan A.R. Modeling of injuries in a study of the applicative of hemostatic sponge implants in the in vivo experiment. ENI Transbaikal Medical Bulletin, № 1/2019. pp. 155-166.
10. Gabay, M and Boucher B.A. An essential primer for understanding the role of topical hemostats, surgical sealants, and adhesives for maintaining hemostasis. Pharmacotherapy – 2013 – 33(9) – p 935-55.
11. Sharma J.B., Zangmo R., Kumar S., Roy K.K. Use of oxidized regenerated cellulose (Surgicel Nu-Knit) as a hemostat in laparoscopic endometriotic cystectomy: a case report. Int Reprod Contracept Obstet Gynecol. -2015 – 4(1) –P. 283-285.
12. Struszyk M. H., Wilbik - Halgas B., Miklas M., et al. Estimation of the performance stability of the newly developed topical hemostatic agents based on the chitosan/alginate fibrids. Text Res J – 2017 – 87 – P. 780-789.
13. Kholturaev B.Zh. dis. ... can. chem. Sci. Tashkent: Institute of Chemical Physics of the Academy of Sciences of the Republic of Uzbekistan, 2023.
14. Ismoilov B.A. Dis... can. honey. Sci. Tashkent: RNIMC, 2019.
15. Youngjun A., Jong H.J., Chul S.B., Young H.Y., Thriveni Th., Ji Whan A., and Choon H. / Synthesis and Non-Isothermal Crystallization Behaviors of Maleic Anhydride onto High Density Polethylene// Journal of the Korean Ceramic Society//Vol. 53, No. 1, pp. 24-33, 2016.
16. ]. Han Ya, Yefei Zh, Ryo K, Stuart J. Preparation of cellulose nanofibers from Miscanthus x. Giganteus by ammonium persulfate oxidation. 2019. Pages 30-39.
17. Konduri, M. K. R., Koteswarareddy, G., Rohini Kumar, D. B., Venkata Reddy, B., & Lakshmi Narasu, M. (2011). Effect of pro-oxidants on biodegradation of polethylene (LDPE) by indigenous fungal isolate, Aspergillus oryzae. Journal of Applied Polymer Science, 120(6), 3536–3545.
2. Budko E. V., Chernikova D. A., Yampolsky L. M., Yatsyuk V. Ya. Local hemostatic agents and ways to improve them. Russian Medical and Biological Bulletin named after Academician I.P. Pavlova. 2019. V. 27. №2. pp. 274-285.
3. Treskova V. I., Shipina O. T., Romanova S. M., Nikitin V. G. Chemical modification of carboxymethylcellulose with diaminofurazan. Bulletin of the Technological University. 2016. V.19, №12 P. 172-175.
4. Sarymsakov А.А., Yunusov KhE. Preparation and properties of antistatic hydrogel "Aspike". Pharmaceutical journal. 2015. № 3. pp. 60-65.
5. Grigoriev I.A., Morozov S.V., Tkacheva N.I., Pankrushina N.A., Chernyavsky A.M., Tarkova A.R. A method for producing a hemostatic agent based on oxidized cellulose using microwave exposure. Published: 09/20/2015. Bull. № 26.
6. Lipatov V.A., Severinov D.A., Saakyan A.R. Local applicational blood reestablishing instruments in surgery of the XXI century (literary review). Innova. 2019;(1):16-22.
7. Tarkova A.R. The effectiveness of various forms of local hemostatic materials based on oxidized cellulose in the experiment “Bulletin of Surgery named after. I.I. Grekova." - 2015. -V. 174. - № 6. - P. 56-60.
8. Bicer A.S. Bayram, O. Gurbuz et al. Assessment of the efficacy of bioabsorbable oxidized regenerated cellulose for prevention of post-operative pericardial adhesion in the rabbit model. J. Int. Med. Res. - 2008. № 36. - P. 1311-1318.
9. Lipatov V.A., Lazarenko S.V., Severinov D.A., Saakyan A.R. Modeling of injuries in a study of the applicative of hemostatic sponge implants in the in vivo experiment. ENI Transbaikal Medical Bulletin, № 1/2019. pp. 155-166.
10. Gabay, M and Boucher B.A. An essential primer for understanding the role of topical hemostats, surgical sealants, and adhesives for maintaining hemostasis. Pharmacotherapy – 2013 – 33(9) – p 935-55.
11. Sharma J.B., Zangmo R., Kumar S., Roy K.K. Use of oxidized regenerated cellulose (Surgicel Nu-Knit) as a hemostat in laparoscopic endometriotic cystectomy: a case report. Int Reprod Contracept Obstet Gynecol. -2015 – 4(1) –P. 283-285.
12. Struszyk M. H., Wilbik - Halgas B., Miklas M., et al. Estimation of the performance stability of the newly developed topical hemostatic agents based on the chitosan/alginate fibrids. Text Res J – 2017 – 87 – P. 780-789.
13. Kholturaev B.Zh. dis. ... can. chem. Sci. Tashkent: Institute of Chemical Physics of the Academy of Sciences of the Republic of Uzbekistan, 2023.
14. Ismoilov B.A. Dis... can. honey. Sci. Tashkent: RNIMC, 2019.
15. Youngjun A., Jong H.J., Chul S.B., Young H.Y., Thriveni Th., Ji Whan A., and Choon H. / Synthesis and Non-Isothermal Crystallization Behaviors of Maleic Anhydride onto High Density Polethylene// Journal of the Korean Ceramic Society//Vol. 53, No. 1, pp. 24-33, 2016.
16. ]. Han Ya, Yefei Zh, Ryo K, Stuart J. Preparation of cellulose nanofibers from Miscanthus x. Giganteus by ammonium persulfate oxidation. 2019. Pages 30-39.
17. Konduri, M. K. R., Koteswarareddy, G., Rohini Kumar, D. B., Venkata Reddy, B., & Lakshmi Narasu, M. (2011). Effect of pro-oxidants on biodegradation of polethylene (LDPE) by indigenous fungal isolate, Aspergillus oryzae. Journal of Applied Polymer Science, 120(6), 3536–3545.
Published
2024-07-22
How to Cite
Kholturaev Bakhriddin Zhumaevich, Yarmatov Sardorbek Sobirjonovich, Yunusov Khaydar Ergashovich, & Sarymsakov Abdushkur Abdukhalilovich. (2024). Hemostatic Nanobiocomposite Based on the Base Cellulose Derivatives. Central Asian Journal of Medical and Natural Science, 5(4), 191-197. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2538
Section
Articles
