Effects of bee glue on oxidant-antioxidant balance and renal funication in the male rat exposed to oxidative stress induced by hydrogen peroxide
Keywords:
Glutathione, Malondialdehyde, Propolis, Blood Urea nitrogen, CcCL,BUN/Creatinine ratio
Abstract
This study was carried out from January to March 2024, aimed at assessing the impact of bee glue extracts (aquatic and ethanolic) on the oxidant-antioxidant balance by estimating the concentration of certain antioxidants and their indicators such as glutathione (GSH) and malondialdehyde (MDA), as well as assessing their impact on kidney functions by estimating the concentration of urea , creatinine, Blood urea nitrogen (BUN),BUN/Creatinine ratio and creatinine clearance (CrCl) among male rats exposed to hydrogen peroxide-induced oxidation stress. The results showed that treatment with bee glue extracts led to an increase in GSH , BUN/Creatinine ratio and CrCl levels in serum and a decrease in MDA, urea, creatinine and BUN levels compared to the H2O2 group. The study results indicate that both aqueous and alcoholic extracts of bee glue have a preventive role against oxidative damage caused by stress. This is achieved by improving the levels of GSH , BUN/Creatinine ratio and CrCl levels and reducing the level of lipid peroxidation (MDA). Additionally, the kidney function is enhanced by reducing the levels of urea , creatinine and BUN in rats treated with H2O2.
References
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[21] Y. A. Sulaiman, K. Al-saeedy, and M. M. Al-Anzy, ‘Effect of aqueous extract of Asparagus officinalis on some Antioxidants in Rats Exposed to Oxidative Stress induced by Hydrogen peroxide’, Tikrit J. Pure Sci., vol. 22, no. 5, pp. 103–109, 2017.
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[24] A. Gęgotek and E. Skrzydlewska, ‘Biological effect of protein modifications by lipid peroxidation products’, Chem. Phys. Lipids, vol. 221, pp. 46–52, 2019.
[25] D. B. Al-Youzbaki, N. S. Khalil, and R. S. Tawfeeq, ‘Risk Factors Of Cervical Spines Osteoarthritis In Adult Women: Case-Control Study’, Syst. Rev. Pharm., vol. 12, no. 1, pp. 272–275, 2021.
[26] A. Abd-Elrazek, S. Mahmoud, and A. Abd ElMoneim, ‘The comparison between curcumin and propolis against sepsis-induced oxidative stress, inflammation, and apoptosis in kidney of adult male rat’, Future J. Pharm. Sci., vol. 6, no. 1, p. 86, Dec. 2020, doi: 10.1186/s43094-020-00104-3.
[27] J. K. Abd-Alhassen, I. A. Mohammed, and A. F. Daham, ‘In vitro and in vivo antioxidant activity of Iraqi propolis against benign prostatic hyperplasia in rats’, EurAsian J. Biosci., vol. 14, no. 2, pp. 7467–7472, 2020.
[28] M. Özçelik, M. Erişir, O. Güler, and M. Baykara, ‘The Effect of Propolis on Oxidative Damage Induced by Whole Body Irradiation in Rats.’, Firat Univ. Saglik Bilim. Vet. Derg., vol. 34, no. 2, 2020, Accessed: Apr. 24, 2024. [Online]. Available: http://veteriner.fusabil.org/pdf/pdf_FUSABIL_1433.pdf
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[31] S. Kumar and A. K. Pandey, ‘Chemistry and biological activities of flavonoids: an overview’, Sci. World J., vol. 2013, 2013, Accessed: Apr. 24, 2024. [Online]. Available: https://www.hindawi.com/journals/tswj/2013/162750/abs/
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Published
2024-07-15
How to Cite
Khudhur , A. F., Hamad , R. H., & Nasser Abdullah , A. A. (2024). Effects of bee glue on oxidant-antioxidant balance and renal funication in the male rat exposed to oxidative stress induced by hydrogen peroxide. Central Asian Journal of Medical and Natural Science, 5(4), 150-159. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2532
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Articles
