Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst

  • Mohammed Jwher Saleh Salah al-Din Education Directorate/Iraq
  • Jamil Nadhem Saleh Salah al-Din Education Directorate/Iraq
  • Khalid Al-Badrany Tikrit University, College of Education for Pure Sciences/Departement of Chemistry
  • Adil Hussein Dalaf Department of Chemistry, College of Science, Tikrit University, Tikrit-Iraq
  • Reem Suhail Najm Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Tikrit, Salahuddin-Tikrit, Iraq
  • Abdul Wahed Abdul Sattar Talluh Tikrit University, College of Basic Education, Shirqat, Tikrit, Iraq
Keywords: catalyst, pyran, biological activity

Abstract

The research included preparing a basic catalyst by reacting potassium nitrate with alumina to produce the heterogeneous solid basic catalyst and then introducing the catalyst as a catalyst in preparing the 2-amino pyrane ring by reacting the prepared chocolate with malononitrile and using only stirring without sublimation or heating. The compositions were validated using physical measurements such as percentage, melting point, and colour and spectroscopic measurements such as proton and carbon nuclear magnetic resonance and infrared spectra. The nanoscale size of the catalyst was also confirmed by scanning electron microscope (SEM) analysis. Two types of positive bacteria were used—gram and gram-negative to verify biological activity.

References

Sheldon, R.A. and Bekkum, H.V. (2001). "Fine Chemical Through Heterogenous Catalysis", Wiley VCH Verlag, Germany, p.p.2-5.

Kerru, N., Gummidi, L., Maddila, S., & Jonnalagadda, S. B. (2021). A review of recent advances in the green synthesis of azole-and pyran-based fused heterocycles using MCRs and sustainable catalysts. Current Organic Chemistry, 25(1), 4-39.‏

Tashrifi, Z., Mohammadi-Khanaposhtani, M., Hamedifar, H., Larijani, B., Ansari, S., & Mahdavi, M. (2020). Synthesis and pharmacological properties of polysubstituted 2-amino-4H-pyran-3-carbonitrile derivatives. Molecular Diversity, 24(4), 1385-1431.‏

Waghmare, A. S., Pandit, S. S., & Suryawanshi, D. M. (2018). DABCO catalyzed green and efficient synthesis of 2-Amino-4H-Pyrans and their biological evaluation as antimicrobial and anticancer agents. Combinatorial Chemistry & High Throughput Screening, 21(4), 254-261.

Maddahi, M., Asghari, S., & Pasha, G. F. (2023). A facile one-pot green synthesis of novel 2-amino-4 H-chromenes: antibacterial and antioxidant evaluation. Research on Chemical Intermediates, 49(1), 253-272.

Lagu, S. B., Yejella, R. P., Nissankararao, S., Bhandare, R. R., Golla, V. S., Subrahmanya Lokesh, B. V., ... & Shaik, A. B. (2022). Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies. PloS one, 17(6), e0265068..‏

Hadiyal, S. D., Parmar, N. D., Kalavadiya, P. L., Lalpara, J. N., & Joshi, H. S. (2020). Microwave-Assisted Three-Component Domino Synthesis of Polysubstituted 4H-Pyran Derivatives and Their Anticancer Activity. Russian Journal of Organic Chemistry, 56(4), 671-678.‏

Suthar, M., Kumbhani, J., & d BHATT, K. E. Y. U. R. (2021). Pyran Heterocyclic Compound as the Prosperous Scaffolds for Biological Sensor (A-Review). Oriental Journal Of Chemistry, (6), 1280-1286..‏

Al-Joboury, W. M., Al-Badrany, K. A., & Asli, N. J. (2022, November). N-alkylation of substituted 2-amino benzothiazoles by 1, 4-bis (bromo methyl) benzene on mixed oxides at room temperature and study their biological activity. In AIP Conference Proceedings (Vol. 2394, No. 1, p. 040054). AIP Publishing LLC.

Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.‏

Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.‏

Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & Mohammed Saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 326-332.‏

Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.‏

Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazolidine Derivatives. World of Science: Journal of Modern Research Technologies 2024, 3(2), 49-57.

Al-Badrany, K. A. (2024). THE USE OF 2-AMINOPYRAZINE AS A BASIC NUCLEOPHILE FOR THE PREPARATION OF NEW DERIVATIVES OF THE 5, 6-DIHYDROPYRIDINE-2 (1H)-YLIDENE) CYANAMIDE RING, THEIR DIAGNOSIS, AND EVALUATION OF THEIR BACTERIAL EFFICACY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(5), 508-518.‏

Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, and characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.‏

Abdullah, S. H., Salih, M. M., & Khalid, A. Synthesis, Characterization and Antibacterial Evaluation of Novel Thiazolidine Derivatives.‏

Abdul Wahed, A. S. T. (2024). Preparation and Evaluation of Bacterial Activity and Study of the Crystalline Properties of Some 1, 3-Oxazepine-4, 7-Dione Derivatives. Central Asian Journal of Theoretical and Applied Sciences, 5(2), 15-26.‏

Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 155-168.‏

Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23

Published
2024-07-25
How to Cite
Mohammed Jwher Saleh, Jamil Nadhem Saleh, Khalid Al-Badrany, Adil Hussein Dalaf, Reem Suhail Najm, & Abdul Wahed Abdul Sattar Talluh. (2024). Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst. Central Asian Journal of Medical and Natural Science, 5(4), 130 - 138. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2530
Section
Articles