COVID 19 Severely Disrupts Blood Markers and Renal Function

  • Muntadher Mohammed Jaber Iraqi Ministry of Health, Thi Qar Health Office, Thi Qar, Iraq
  • Falah Herez Madhloom Alrabea Iraqi Ministry of Health, Thi Qar Health Office, Thi Qar, Iraq
  • Samer Kareem Hanoon Iraqi Ministry of Health, Thi Qar Health Office, Thi Qar, Iraq
  • Ali Ghaleb Ammar Iraqi Ministry of Health, Thi Qar Health Office, Thi Qar, Iraq
Keywords: Covid 19, WBC, RFT, D. dimer, Ferritin

Abstract

Since the emergence of COVID-19 in Wuhan, extensive research has explored its immediate and long-term effects. This study investigated the relationship between COVID-19 and blood disorders, liver proteins, and biochemical factors. We analyzed 150 samples divided into two groups: 75 COVID-19 patients and 75 healthy, recovered individuals aged 25-75 years. The study examined various hematological and biochemical markers, including WBC, lymphocytes, platelet count, NLR, RBC, CRP, BUN, creatinine, D-dimer, and ferritin. Significant differences were found in hemoglobin levels, WBC count, RBC, blood urea, and serum creatinine, with COVID-19 patients showing increased levels of these markers except for hemoglobin, which decreased. The results indicate that COVID-19 adversely affects hematological markers, renal function, and induces abnormal immune responses. Moreover, the severity of illness is positively associated with blood hemolysis and D-dimer levels, leading to hyperglycemia and pancreatic effects by inhibiting insulin synthesis. These findings underscore the impact of COVID-19 on blood parameters and organ function.

Author Biography

Muntadher Mohammed Jaber, Iraqi Ministry of Health, Thi Qar Health Office, Thi Qar, Iraq

College of Health and Medical Technologies, National University for Science and Technology, Thi Qar, Iraq

References

[1] C. Huang, Y. Wang, X. Li, L. Ren, J. Zhao, Y. Hu, ... and B. Cao, "Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China," *The Lancet*, vol. 395, no. 10223, pp. 497-506, 2020.
[2] C. Sohrabi, Z. Alsafi, N. O'Neill, M. Khan, A. Kerwan, A. Al-Jabir, ... and R. Agha, "World Health Organization Declares Global Emergency: A Review of the 2019 Novel Coronavirus (COVID-19)," *International Journal of Surgery*, vol. 76, pp. 71-76, 2020.
[3] M. Khan, S. F. Adil, H. Z. Alkhathlan, M. N. Tahir, S. Saif, M. Khan, and S. T. Khan, "COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far," *Molecules*, vol. 26, no. 1, p. 39, 2020.
[4] H. Lu, C. W. Stratton, and Y. W. Tang, "Outbreak of Pneumonia of Unknown Etiology in Wuhan, China: The Mystery and the Miracle," *Journal of Medical Virology*, vol. 92, no. 4, p. 401, 2020.
[5] E. C. Abebe, T. A. Dejenie, M. Y. Shiferaw, and T. Malik, "The Newly Emerged COVID-19 Disease: A Systemic Review," *Virology Journal*, vol. 17, no. 1, p. 1, 2020.
[6] D. McGonagle, K. Sharif, A. O'Regan, and C. Bridgewood, "The Role of Cytokines Including Interleukin-6 in COVID-19 Induced Pneumonia and Macrophage Activation Syndrome-Like Disease," *Autoimmunity Reviews*, vol. 19, no. 6, p. 102537, 2020.
[7] Q. Ruan, K. Yang, W. Wang, L. Jiang, and J. Song, "Clinical Predictors of Mortality Due to COVID-19 Based on an Analysis of Data of 150 Patients from Wuhan, China," *Intensive Care Medicine*, vol. 46, no. 5, pp. 846-848, 2020.
[8] A. Ma, J. Cheng, J. Yang, M. Dong, X. Liao, and Y. Kang, "Neutrophil-to-Lymphocyte Ratio as a Predictive Biomarker for Moderate-Severe ARDS in Severe COVID-19 Patients," *Critical Care*, vol. 24, pp. 1-4, 2020.
[9] H. Afsin and G. Aktas, "Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios Are Useful in Differentiation of Thyroid Conditions with Normal and Increased Uptake," *Ethiopian Journal of Health Development*, vol. 35, no. 3, 2021.
[10] G. Aktas, "Hematological Predictors of Novel Coronavirus Infection," *Revista da Associação Médica Brasileira*, vol. 67, pp. 1-2, 2021.
[11] K. Keykavousi, F. Nourbakhsh, N. Abdollahpour, F. Fazeli, A. Sedaghat, V. Soheili, and A. Sahebkar, "A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease," *International Journal of Analytical Chemistry*, 2022.
[12] M. S. Asghar, N. A. Khan, S. J. Haider Kazmi, A. Ahmed, M. Hassan, R. Jawed, ... and S. B. Tirmizi, "Hematological Parameters Predicting Severity and Mortality in COVID-19 Patients of Pakistan: A Retrospective Comparative Analysis," *Journal of Community Hospital Internal Medicine Perspectives*, vol. 10, no. 6, pp. 514-520, 2020.
[13] E. Usul, I. Şan, B. Bekgöz, and A. Şahin, "Role of Hematological Parameters in COVID-19 Patients in the Emergency Room," *Biomarkers in Medicine*, vol. 14, no. 13, pp. 1207-1215, 2020.
[14] A. Anurag, P. K. Jha, and A. Kumar, "Differential White Blood Cell Count in the COVID-19: A Cross-Sectional Study of 148 Patients," *Diabetes & Metabolic Syndrome: Clinical Research & Reviews*, vol. 14, no. 6, pp. 2099-2102, 2020.
[15] F. L. Rangel, "Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-C Reactive Protein in Patients with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis," *Journal of Medical Virology*, vol. 92, no. 10, pp. 1733-1734, 2020.
[16] H. F. Peñaloza, J. S. Lee, and P. Ray, "Neutrophils and Lymphopenia, an Unknown Axis in Severe COVID-19 Disease," *PLOS Pathogens*, vol. 17, no. 9, p. e1009850, 2021.
[17] S. Aktar, M. M. Ahamad, M. Rashed-Al-Mahfuz, A. K. M. Azad, S. Uddin, A. H. M. Kamal, ... and M. A. Moni, "Predicting Patient COVID-19 Disease Severity by Means of Statistical and Machine Learning Analysis of Blood Cell Transcriptome Data," *arXiv preprint*, arXiv:2011.10657, 2020.
[18] F. Ok, O. Erdogan, E. Durmus, S. Carkci, and A. Canik, "Predictive Values of Blood Urea Nitrogen/Creatinine Ratio and Other Routine Blood Parameters on Disease Severity and Survival of COVID‐19 Patients," *Journal of Medical Virology*, vol. 93, no. 2, pp. 786-793, 2021.
[19] Y. Cheng, R. Luo, K. Wang, M. Zhang, Z. Wang, L. Dong, ... and G. Xu, "Kidney Disease is Associated with In-Hospital Death of Patients with COVID-19," *Kidney International*, vol. 97, no. 5, pp. 829-838, 2020.
[20] K. H. Chu, W. K. Tsang, C. S. Tang, M. F. Lam, F. M. Lai, K. F. To, ... and K. N. Lai, "Acute Renal Impairment in Coronavirus-Associated Severe Acute Respiratory Syndrome," *Kidney International*, vol. 67, no. 2, pp. 698-705, 2005.
[21] Y. L. Ge, C. H. Liu, N. Wang, J. Xu, X. Y. Zhu, C. S. Su, ... and H. Y. Wang, "Elevated Plasma D-Dimer in Adult Community-Acquired Pneumonia Patients is Associated with an Increased Inflammatory Reaction and Lower Survival," *Clinical Laboratory*, vol. 65, 2019.
[22] H. Qiu, J. Wu, L. Hong, Y. Luo, Q. Song, and D. Chen, "Clinical and Epidemiological Features of 36 Children with Coronavirus Disease 2019 (COVID-19) in Zhejiang, China: An Observational Cohort Study," *The Lancet Infectious Diseases*, vol. 20, no. 6, pp. 689-696, 2020.
[23] F. Jiang, L. Deng, L. Zhang, Y. Cai, C. W. Cheung, and Z. Xia, "Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19)," *Journal of General Internal Medicine*, vol. 35, pp. 1545-1549, 2020.
[24] T. M. John, C. N. Jacob, and D. P. Kontoyiannis, "When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis," *Journal of Fungi*, vol. 7, no. 4, p. 298, 2021.
[25] Y. Liang, Q. Wang, Y. Zhao, X. Niu, Y. Chen, X. Chen, ... and S. Wu, "The Diagnostic Value of Multi-Index Combined Detection in Patients with COVID-19," *Clinical Laboratory*, 2020.
[26] S. Bhandari, A. Shaktawat, A. Tak, B. Patel, J. Shukla, S. Singhal, ... and A. Dube, "Logistic Regression Analysis to Predict Mortality Risk in COVID-19 Patients from Routine Hematologic Parameters," *Ibnosina Journal of Medicine and Biomedical Sciences*, vol. 12, no. 2, pp.
Published
2024-06-07
How to Cite
Jaber, M. M., Alrabea, F. H. M., Hanoon, S. K., & Ammar, A. G. (2024). COVID 19 Severely Disrupts Blood Markers and Renal Function. Central Asian Journal of Medical and Natural Science, 5(3), 504-515. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2474
Section
Articles