Diabetes Patients Show Elevated Adipokines, Glucose, and Insulin Resistance Markers

Hussein Mohammed Abdullah; Nour Abdulehsan  Dhannoon; Hana Attiya  Salman

Hussein Mohammed Abdullah Biology Department, College of Education, Kirkuk University, Kirkuk, Iraq
Nour Abdulehsan Dhannoon Biology Department, College of Education, Kirkuk University, Kirkuk, Iraq
Hana Attiya Salman Biology Department, College of Education, Kirkuk University, Kirkuk, Iraq

Keywords: Vit. D, T1DM, Leptin, Vitamin-D, Adiponectin

Abstract

This study evaluated adipokines and biochemical parameters in 70 children (44 males, 26 females, age 5-13 years, mean±SD 8.7±3.32 years) with type 1 diabetes mellitus (T1DM) and 30 healthy controls. Conducted at Azadi Teaching Hospital from December 2023 to February 2024, the study aimed to compare glucose, HbA1c, vitamin D, lactate dehydrogenase (LDH), adiponectin, and leptin levels between T1DM patients and healthy children. Results showed significant increases in glucose (321.93±89.15 vs. 85.21±9.46 mg/dL), HbA1c (12.04±1.83% vs. 5.01±0.31%), LDH (284.22±21.94 vs. 89.13±7.42 U/L), adiponectin (9.26±0.28 vs. 3.62±0.94 µg/mL), and leptin (21.84±2.62 vs. 4.48±0.62 ng/mL), and a significant decrease in vitamin D (13.93±4.93 vs. 28.72±6.08 ng/mL) in T1DM patients (P<0.05 for all). These findings highlight the importance of monitoring vitamin D and adipokine levels in children with T1DM, suggesting potential roles in disease management and complications prevention.

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