The Role of Annexin A1, Copeptin, Cholesterol Concentration and AST activity in Serum of Primary Hypothyroidism Women Obese Patients
Keywords:
AnxA1, primary, Copeptin, AST
Abstract
Thyroid hormones, plays an a major important and essential functions in metabolic processes. Hypothyroidism is caused by inadequate thyroid hormone synthesis or activity in target tissues. Annexin A1 (AnxA1), is a key factor that have a role in the defense against inflammation and it is considered as endogenous agent that effects on the some types of steroid hormones (glucocorticoids). Copeptin is a small molecule that has a leucine-rich sequence, discovered by Holwerda et al. have a leucine repeats. It is share the precursor molecule with vasopressin - neurophysin II. The eighty women patients suffering have primary hypothyroidism women were participated, their ages ranged from 30 to 45 years. There a significant decrease (P>0.05) in T3 and T4 levels, a highly significant increase (<0.01) in TSH, AnxA1 and cholesterol, a significant increase (p<0.05) in the serum levels of Copeptin and AST activity in women patients group when compared to women control group.
References
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Y. Alshuweishi, M. Alfaifi, Y. Almoghrabi, and M. A. Alfhili, “AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study,” Life, 2023, [Online]. Available: https://www.mdpi.com/2075-1729/13/9/1881
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M. Gu, X. Han, X. Liu, F. Sui, Q. Zhang, and S. Pan, “Predictive Value of Annenxin A1 for Disease Severity and Prognosis in Patients with Community-Acquired Pneumonia,” Diagnostics, 2023, [Online]. Available: https://www.mdpi.com/2075-4418/13/3/396
L. Prieto-Fernández, S. T. Menéndez, and ..., “Pathobiological functions and clinical implications of annexin dysregulation in human cancers,” Frontiers in cell and …, 2022, doi: 10.3389/fcell.2022.1009908.
Y. Li et al., “Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2,” Oncogene, 2011, [Online]. Available: https://www.nature.com/articles/onc2011112
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G. Tuli, J. Munarin, D. Tessaris, S. Einaudi, and ..., “Distribution of plasma copeptin levels and influence of obesity in children and adolescents,” European journal of …, 2021, doi: 10.1007/s00431-020-03777-3.
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H. Szmygin, J. Szydełko, and ..., “Copeptin as a novel biomarker of cardiometabolic syndrome,” Endokrynologia …, 2021, [Online]. Available: https://journals.viamedica.pl/endokrynologia_polska/article/view/83891
J. Jonklaas, “Hypothyroidism, lipids, and lipidomics,” Endocrine, 2023, doi: 10.1007/s12020-023-03420-9.
L. H. Duntas and G. Brenta, “A renewed focus on the association between thyroid hormones and lipid metabolism,” Front Endocrinol (Lausanne), 2018, doi: 10.3389/fendo.2018.00511.
F. Tarboush, M. Alsultan, and Z. Alourfi, “The correlation of lipid profile with subclinical and overt hypothyroidism: A cross-sectional study from Syria,” Medicine, 2023, [Online]. Available: https://journals.lww.com/md-journal/fulltext/2023/09150/the_correlation_of_lipid_profile_with_subclinical.94.aspx?context=latestarticles
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E. Piantanida, S. Ippolito, D. Gallo, E. Masiello, and ..., “The interplay between thyroid and liver: implications for clinical practice,” Journal of …, 2020, doi: 10.1007/s40618-020-01208-6.
G. E. Chung et al., “Non-alcoholic fatty liver disease across the spectrum of hypothyroidism,” Journal of …, 2012, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S0168827812002152
A. Lonardo, S. Ballestri, A. Mantovani, and ..., “Pathogenesis of hypothyroidism-induced NAFLD: Evidence for a distinct disease entity?,” Digestive and Liver …, 2019, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1590865818314427
Published
2024-04-29
How to Cite
Kadhim, N. Q., Al-Faraji, S. M., Ayed, S. B., & Mustafa, I. F. (2024). The Role of Annexin A1, Copeptin, Cholesterol Concentration and AST activity in Serum of Primary Hypothyroidism Women Obese Patients. Central Asian Journal of Medical and Natural Science, 5(2), 186-194. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2412
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