Effect of SLC30A8 rs13266634 Genetic Polymorphism with Diabetic Nephropathy Patients
A Case-Control Study
Keywords:
diabetic nephropathy, DN, Zinc transport ZnT8, SLC30A8, diabetic kidney disease, DKD
Abstract
Diabetic nephropathy is a pathological disease that is commonly observed in persons with diabetes. The purpose of this research was to compare the effects of the SLC30A8 rs13266634 gene polymorphism on people with and without diabetic nephropathy. The study comprised 170 patients, aged 40 to 75, who were admitted to the dialysis unit at the Al-Diwaniyah Teaching Hospital in Iraq in 2021 and 2022. There is a connection between SLC30A8 gene polymorphisms and diabetic nephropathy, according to the results of a study looking at the interaction between comorbid diseases and patients with the disease. Particularly, we discovered that individuals with the C allele of T/C (OR = 0.509, 95% Cl = 0.307- 0.843, p-value = 0.008 < 0.05), the TC genotype of T/C (OR = 0.280, 95% Cl = 0.118- 0.665, p-value = 0.003 < 0.05), and the TC & CC genotype had higher odds of infection with DN compared to the TT genotype (OR = 0.391, 95% Cl = 0.203- 0.756, p-value = 0.005 < 0.05).
References
S. Shafi, N. Tabassum, and F. Ahmad, “Diabetic nephropathy and herbal medicines,” International Journal of …, 2012, [Online]. Available: https://www.academia.edu/download/68823734/Diabetic_nephropathy_and_herbal_medicine20210820-26876-1prx04r.pdf
M. K. Sagoo and L. Gnudi, “Diabetic nephropathy: an overview,” Diabetic nephropathy: methods and protocols, 2020, doi: 10.1007/978-1-4939-9841-8_1.
S. Broadgate, C. Kiire, S. Halford, and ..., “Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy,” Acta Ophthalmol, 2018, doi: 10.1111/aos.13678.
N. Papadopoulou-Marketou and ..., “Biomarkers of diabetic nephropathy: A 2017 update,” Critical reviews in …, 2017, doi: 10.1080/10408363.2017.1377682.
K. K. Vattam, S. Movva, I. A. Khan, P. Upendram, and ..., “Importance of gene polymorphisms in renal transplant patients to prevent post transplant diabetes,” J Diabetes Metab, 2014.
V. Natesan and S. J. Kim, “Diabetic nephropathy–a review of risk factors, progression, mechanism, and dietary management,” Biomolecules &therapeutics, 2021, [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255138/
A. R. Correia, “Inhibition of inflammatory cytokines - potential new treatment for diabetic nephropathy,” ProQuest Dissertations and Theses, 2015.
J. Kopel, C. Pena-Hernandez, and K. Nugent, “Evolving spectrum of diabetic nephropathy,” World J Diabetes, 2019, [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522757/
M. S. H. Akash, K. Rehman, and A. Liaqat, “Tumor necrosis factor‐alpha: role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus,” Journal of cellular …, 2018, doi: 10.1002/jcb.26174.
M. J. Daniels, M. Jagielnicki, and M. Yeager, “Structure/Function analysis of human ZnT8 (SLC30A8): A diabetes risk factor and zinc transporter,” Current research in structural …, 2020, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S2665928X2030012X
K. J. Bosma, K. E. Syring, J. K. Oeser, J. D. Lee, and ..., “Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in …,” Journal of molecular …, 2019, doi: 10.1007/s00239-019-09898-0.
S. Mashal, M. Khanfar, S. Al-Khalayfa, L. Srour, L. Mustafa, and ..., “SLC30A8 gene polymorphism rs13266634 associated with increased risk for developing type 2 diabetes mellitus in Jordanian population,” Gene, 2021, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S0378111920309483
N. Kanauchi, S. Ookawara, K. Ito, S. Mogi, and ..., “Factors affecting the progression of renal dysfunction and the importance of salt restriction in patients with type 2 diabetic kidney disease,” Clinical and …, 2015, doi: 10.1007/s10157-015-1118-y.
Z. Lin, Y. Wang, B. Zhang, and Z. Jin, “Association of type 2 diabetes susceptible genes GCKR, SLC30A8, and FTO polymorphisms with gestational diabetes mellitus risk: a meta-analysis,” Endocrine, 2018, doi: 10.1007/s12020-018-1651-z.
T. D. Aka, U. Saha, S. A. Shati, M. A. Aziz, M. Begum, and ..., “Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: a case-control study,” Heliyon, 2021, [Online]. Available: https://www.cell.com/heliyon/pdf/S2405-8440(21)02479-8.pdf
N. V. Hojs, S. Bevc, R. Ekart, and R. Hojs, “Oxidative stress markers in chronic kidney disease with emphasis on diabetic nephropathy,” Antioxidants, 2020, [Online]. Available: https://www.mdpi.com/2076-3921/9/10/925
L. L. Fu, Y. Lin, Z. L. Yang, and Y. B. Yin, “Association analysis of genetic polymorphisms of TCF7L2, CDKAL1, SLC30A8, HHEX genes and microvascular complications of type 2 diabetes mellitus,” Zhonghua yi xue yi Chuan xue za …, 2012, [Online]. Available: https://europepmc.org/article/med/22487833
G. Chen et al., “Association study of genetic variants of 17 diabetes‐related genes/loci and cardiovascular risk and diabetic nephropathy in the C hinese S he population (中国畲族 …,” Journal of …, 2013, doi: 10.1111/1753-0407.12025.
E. De la Cruz-Cano, C. C. Jiménez-González, and ..., “Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review,” BMC Nephrol, 2019, doi: 10.1186/s12882-019-1590-9.
M. Nehru, “Impact of bisphenol a on the levels of vascular calcification biomarkers in type 2 diabetes mellitus with vascular complications: A case-control study,” Emerg Contam, vol. 10, no. 4, 2024, doi: 10.1016/j.emcon.2024.100342.
Y. Kuang, “Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p,” BMC Nephrol, vol. 25, no. 1, 2024, doi: 10.1186/s12882-024-03562-6.
S. Wu, “Navigating the future of diabetes: innovative nomogram models for predicting all-cause mortality risk in diabetic nephropathy,” BMC Nephrol, vol. 25, no. 1, 2024, doi: 10.1186/s12882-024-03563-5.
F. Kliewe, “Zyxin is important for the stability and function of podocytes, especially during mechanical stretch,” Commun Biol, vol. 7, no. 1, 2024, doi: 10.1038/s42003-024-06125-5.
K. Mise, “Correction to: NDUFS4 regulates cristae remodeling in diabetic kidney disease (Nature Communications, (2024), 15, 1, (1965), 10.1038/s41467-024-46366-w),” Nat Commun, vol. 15, no. 1, 2024, doi: 10.1038/s41467-024-47414-1.
F. Liu, “Retraction Note: Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy (Scientific Reports, (2016), 6, 1, (33676), 10.1038/srep33676),” Sci Rep, vol. 14, no. 1, 2024, doi: 10.1038/s41598-024-58326-x.
Z. Liu, “Bioorthogonal photocatalytic proximity labeling in primary living samples,” Nat Commun, vol. 15, no. 1, 2024, doi: 10.1038/s41467-024-46985-3.
W. Geng, “Correction to: Evaluating renal iron overload in diabetes mellitus by blood oxygen level-dependent magnetic resonance imaging: a longitudinal experimental study (BMC Medical Imaging, (2022), 22, 1, (200), 10.1186/s12880-022-00939-7),” BMC Med Imaging, vol. 24, no. 1, 2024, doi: 10.1186/s12880-024-01243-2.
K. S. Wan, “Prevalence of diabetic kidney disease and the associated factors among patients with type 2 diabetes in a multi-ethnic Asian country,” Sci Rep, vol. 14, no. 1, 2024, doi: 10.1038/s41598-024-57723-6.
A. Hayashi, “Effect of multidisciplinary care on diabetic kidney disease: a retrospective cohort study,” BMC Nephrol, vol. 25, no. 1, 2024, doi: 10.1186/s12882-024-03550-w.
S. Cui, “Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease,” Cell Communication and Signaling, vol. 22, no. 1, 2024, doi: 10.1186/s12964-024-01565-2.
M. K. Sagoo and L. Gnudi, “Diabetic nephropathy: an overview,” Diabetic nephropathy: methods and protocols, 2020, doi: 10.1007/978-1-4939-9841-8_1.
S. Broadgate, C. Kiire, S. Halford, and ..., “Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy,” Acta Ophthalmol, 2018, doi: 10.1111/aos.13678.
N. Papadopoulou-Marketou and ..., “Biomarkers of diabetic nephropathy: A 2017 update,” Critical reviews in …, 2017, doi: 10.1080/10408363.2017.1377682.
K. K. Vattam, S. Movva, I. A. Khan, P. Upendram, and ..., “Importance of gene polymorphisms in renal transplant patients to prevent post transplant diabetes,” J Diabetes Metab, 2014.
V. Natesan and S. J. Kim, “Diabetic nephropathy–a review of risk factors, progression, mechanism, and dietary management,” Biomolecules &therapeutics, 2021, [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255138/
A. R. Correia, “Inhibition of inflammatory cytokines - potential new treatment for diabetic nephropathy,” ProQuest Dissertations and Theses, 2015.
J. Kopel, C. Pena-Hernandez, and K. Nugent, “Evolving spectrum of diabetic nephropathy,” World J Diabetes, 2019, [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522757/
M. S. H. Akash, K. Rehman, and A. Liaqat, “Tumor necrosis factor‐alpha: role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus,” Journal of cellular …, 2018, doi: 10.1002/jcb.26174.
M. J. Daniels, M. Jagielnicki, and M. Yeager, “Structure/Function analysis of human ZnT8 (SLC30A8): A diabetes risk factor and zinc transporter,” Current research in structural …, 2020, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S2665928X2030012X
K. J. Bosma, K. E. Syring, J. K. Oeser, J. D. Lee, and ..., “Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in …,” Journal of molecular …, 2019, doi: 10.1007/s00239-019-09898-0.
S. Mashal, M. Khanfar, S. Al-Khalayfa, L. Srour, L. Mustafa, and ..., “SLC30A8 gene polymorphism rs13266634 associated with increased risk for developing type 2 diabetes mellitus in Jordanian population,” Gene, 2021, [Online]. Available: https://www.sciencedirect.com/science/article/pii/S0378111920309483
N. Kanauchi, S. Ookawara, K. Ito, S. Mogi, and ..., “Factors affecting the progression of renal dysfunction and the importance of salt restriction in patients with type 2 diabetic kidney disease,” Clinical and …, 2015, doi: 10.1007/s10157-015-1118-y.
Z. Lin, Y. Wang, B. Zhang, and Z. Jin, “Association of type 2 diabetes susceptible genes GCKR, SLC30A8, and FTO polymorphisms with gestational diabetes mellitus risk: a meta-analysis,” Endocrine, 2018, doi: 10.1007/s12020-018-1651-z.
T. D. Aka, U. Saha, S. A. Shati, M. A. Aziz, M. Begum, and ..., “Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: a case-control study,” Heliyon, 2021, [Online]. Available: https://www.cell.com/heliyon/pdf/S2405-8440(21)02479-8.pdf
N. V. Hojs, S. Bevc, R. Ekart, and R. Hojs, “Oxidative stress markers in chronic kidney disease with emphasis on diabetic nephropathy,” Antioxidants, 2020, [Online]. Available: https://www.mdpi.com/2076-3921/9/10/925
L. L. Fu, Y. Lin, Z. L. Yang, and Y. B. Yin, “Association analysis of genetic polymorphisms of TCF7L2, CDKAL1, SLC30A8, HHEX genes and microvascular complications of type 2 diabetes mellitus,” Zhonghua yi xue yi Chuan xue za …, 2012, [Online]. Available: https://europepmc.org/article/med/22487833
G. Chen et al., “Association study of genetic variants of 17 diabetes‐related genes/loci and cardiovascular risk and diabetic nephropathy in the C hinese S he population (中国畲族 …,” Journal of …, 2013, doi: 10.1111/1753-0407.12025.
E. De la Cruz-Cano, C. C. Jiménez-González, and ..., “Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review,” BMC Nephrol, 2019, doi: 10.1186/s12882-019-1590-9.
M. Nehru, “Impact of bisphenol a on the levels of vascular calcification biomarkers in type 2 diabetes mellitus with vascular complications: A case-control study,” Emerg Contam, vol. 10, no. 4, 2024, doi: 10.1016/j.emcon.2024.100342.
Y. Kuang, “Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p,” BMC Nephrol, vol. 25, no. 1, 2024, doi: 10.1186/s12882-024-03562-6.
S. Wu, “Navigating the future of diabetes: innovative nomogram models for predicting all-cause mortality risk in diabetic nephropathy,” BMC Nephrol, vol. 25, no. 1, 2024, doi: 10.1186/s12882-024-03563-5.
F. Kliewe, “Zyxin is important for the stability and function of podocytes, especially during mechanical stretch,” Commun Biol, vol. 7, no. 1, 2024, doi: 10.1038/s42003-024-06125-5.
K. Mise, “Correction to: NDUFS4 regulates cristae remodeling in diabetic kidney disease (Nature Communications, (2024), 15, 1, (1965), 10.1038/s41467-024-46366-w),” Nat Commun, vol. 15, no. 1, 2024, doi: 10.1038/s41467-024-47414-1.
F. Liu, “Retraction Note: Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy (Scientific Reports, (2016), 6, 1, (33676), 10.1038/srep33676),” Sci Rep, vol. 14, no. 1, 2024, doi: 10.1038/s41598-024-58326-x.
Z. Liu, “Bioorthogonal photocatalytic proximity labeling in primary living samples,” Nat Commun, vol. 15, no. 1, 2024, doi: 10.1038/s41467-024-46985-3.
W. Geng, “Correction to: Evaluating renal iron overload in diabetes mellitus by blood oxygen level-dependent magnetic resonance imaging: a longitudinal experimental study (BMC Medical Imaging, (2022), 22, 1, (200), 10.1186/s12880-022-00939-7),” BMC Med Imaging, vol. 24, no. 1, 2024, doi: 10.1186/s12880-024-01243-2.
K. S. Wan, “Prevalence of diabetic kidney disease and the associated factors among patients with type 2 diabetes in a multi-ethnic Asian country,” Sci Rep, vol. 14, no. 1, 2024, doi: 10.1038/s41598-024-57723-6.
A. Hayashi, “Effect of multidisciplinary care on diabetic kidney disease: a retrospective cohort study,” BMC Nephrol, vol. 25, no. 1, 2024, doi: 10.1186/s12882-024-03550-w.
S. Cui, “Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease,” Cell Communication and Signaling, vol. 22, no. 1, 2024, doi: 10.1186/s12964-024-01565-2.
Published
2024-04-24
How to Cite
Kadhim, N. E., & Hoidy, W. H. (2024). Effect of SLC30A8 rs13266634 Genetic Polymorphism with Diabetic Nephropathy Patients. Central Asian Journal of Medical and Natural Science, 5(2), 157-165. https://doi.org/10.17605/cajmns.v5i2.2409
Issue
Section
Articles
