Experimental Evaluation of a New Method for Achieving Aerostasis in Lung Surgery
Keywords:
aerostasis in lung surgery, hemoben gel, prolonged air leakage, drainage of the pleural cavity, problems of thoracic surgery
Abstract
Postoperative air leakage-alveolo-pleural fistula, is one of the most frequent and insidious complications in thoracic surgery and the main limiting factor in early discharge of patients from the hospital. One of the directions of the search for means to reduce the risk of developing these complications is the development of new implants and methods of their application. In this regard, at the present time, it is necessary to continue the development of new biocompatible coatings and methods of their application. The article considers an experimental evaluation of a new method for ensuring tightness of sutures in lung surgery to reduce the risk of such manifestations as aerostasis failure. The essence of the technique consists in intraparenchymatous injection of a gel substance into the area of lung tissue damage. The biological reactions of tissues and the timing of gel resorption in lung tissue have been studied. This range of research is of fundamental importance for the new techniques created, while the main task is precisely to study the safety of intraparenchymatous use of a gel substance. In this aspect, the effectiveness and duration of aerostasis were evaluated in ex vivo and in vivo experiments. The conducted studies have established that 3.3% Hemoben gel injected into the lung parenchyma at a dose of 1 ml per 1 g does not have an irritating and toxic effect, and according to spectrophotometric studies, it is completely removed from the lung tissue within 7-10 days. At the same time, the proposed technique is characterized by the effectiveness and safety of application, and the results obtained make it possible to apply this method in clinical practice.
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Y. Cai, “Coronavirus Disease 2019 in the Perioperative Period of Lung Resection: A Brief Report From a Single Thoracic Surgery Department in Wuhan, People’s Republic of China,” Journal of Thoracic Oncology, vol. 15, no. 6, pp. 1065–1072, 2020, doi: 10.1016/j.jtho.2020.04.003.
P. Vaidya, “CT derived radiomic score for predicting the added benefit of adjuvant chemotherapy following surgery in stage I, II resectable non-small cell lung cancer: a retrospective multicohort study for outcome prediction,” Lancet Digit Health, vol. 2, no. 3, 2020, doi: 10.1016/S2589-7500(20)30002-9.
V. D. Parshin, “Postoperative drainage of the pleural cavity with aspiration of the contents by high-tech mobile devices,” Pirogov Russian Journal of Surgery, vol. 2021, no. 12, pp. 87–91, 2021, doi: 10.17116/hirurgia202112187.
H. Koo, “Training in lung cancer surgery through the metaverse, including extended reality, in the smart operating room of Seoul National University Bundang Hospital, Korea,” J Educ Eval Health Prof, vol. 18, 2021, doi: 10.3352/JEEHP.2021.18.33.
A. Brunelli, “Ninety-day hospital costs associated with prolonged air leak following lung resection,” Interact Cardiovasc Thorac Surg, vol. 31, no. 4, pp. 507–512, 2020, doi: 10.1093/icvts/ivaa140.
F. Zaraca, “Predicting a Prolonged Air Leak After Video-Assisted Thoracic Surgery, Is It Really Possible?,” Semin Thorac Cardiovasc Surg, vol. 33, no. 2, pp. 581–592, 2021, doi: 10.1053/j.semtcvs.2020.08.012.
A. D. L. Sihoe, “Video-assisted thoracoscopic surgery as the gold standard for lung cancer surgery,” Respirology, vol. 25, pp. 49–60, 2020, doi: 10.1111/resp.13920.
J. Ma, “Robot-assisted thoracic surgery versus video-assisted thoracic surgery for lung lobectomy or segmentectomy in patients with non-small cell lung cancer: a meta-analysis,” BMC Cancer, vol. 21, no. 1, 2021, doi: 10.1186/s12885-021-08241-5.
R. Jin, “A nomogram for preoperative prediction of prolonged air leak after pulmonary malignancy resection,” Transl Lung Cancer Res, vol. 10, no. 8, pp. 3616–3626, 2021, doi: 10.21037/tlcr-21-186.
Published
2024-03-29
How to Cite
Abrarovich, S. R., Rustamjanovich, A. B., & Makhmudjonovich, I. P. (2024). Experimental Evaluation of a New Method for Achieving Aerostasis in Lung Surgery. Central Asian Journal of Medical and Natural Science, 5(2), 82-96. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2403
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Articles
