Chemical Effects on the Origin of Arterial Hypertension  Disease

Salomov Shoxabbos  Nozimjon; Aliev Husniddin  Makhmudovich

Salomov Shoxabbos Nozimjon Andijan State Medical Institute, Uzbekistan
Aliev Husniddin Makhmudovich Andijan State Medical Institute, Uzbekistan

Keywords: Arterial hypertension, cardiovascular disease, chemical exposures, environmental pollutants, heavy metals, pharmaceuticals, endocrine-disrupting chemicals, vascular dysfunction, oxidative stress, inflammation, endothelial dysfunction, blood pressure regulation, epidemiology, risk factors, preventive strategies

Abstract

Arterial hypertension, a pervasive and multifactorial cardiovascular disorder, continues to
pose a significant global health challenge. This paper explores the intricate interplay between
chemical exposures and the onset of arterial hypertension, shedding light on the diverse mechanisms
through which various environmental and endogenous chemicals may contribute to the
development and exacerbation of this disease. Emphasizing the importance of understanding
chemical-induced vascular alterations, the review synthesizes current knowledge on the impact of
pollutants, heavy metals, pharmaceuticals, and endocrine-disrupting chemicals on blood pressure
regulation. Furthermore, it delves into the molecular pathways implicated in chemical-induced
vascular dysfunction, oxidative stress, inflammation, and endothelial dysfunction. A comprehensive
analysis of epidemiological studies and experimental models underscores the relevance of chemical
exposures as potential risk factors for arterial hypertension. Ultimately, this review provides
valuable insights into the complex relationship between chemical agents and the pathogenesis of
arterial hypertension, offering a foundation for future research and preventive strategies.

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