Main Article Content


The vascular endothelium is a unique “endocrine tree” that lines absolutely all organs of the body’s vascular system. Endothelial cells create a barrier between blood and tissues, perform a number of important regulatory functions, synthesizing and secreting a large number of different biologically active substances. The strategic location of the endothelium allows it to be sensitive to changes in the hemodynamic system, signals carried by the blood, and signals from the underlying tissues. In this article was given data about genes which leading to endothelial dysfunction and postpartum hemorrhage and were collected from women with uterine atony in postpartum period.


endothelial dysfunction gene hemodynamic system postpartum hemorrhage uterine atony

Article Details

How to Cite
D. K., N., U. A., A., I. A., K., F. A., A., & U. A., S. (2024). THE ROLE OF ENDOTHELIAL DYSFUNCTION GENES IN THE DEVELOPMENT OF POSTPARTUM HEMORRHAGE. Central Asian Journal of Medical and Natural Science, 5(1), 448-453.


  1. 1. Higashi Y., Noma K., Yoshizumi M. et al. Endothelial function and oxidative stress in cardiovascular diseases // Circulation J. — 2009. — Vol. 3. — Р. 411–415.
  2. 2. Саенко Ю.В., Шутов А.М. Роль оксидативного стресса в патологии сердечно-сосудистой системы у больных с заболеваниями почек // Нефрол. и диализ. — 2004. — Т. 6, №2. — С. 138–139. [Saenko Yu.V., Shutov A.M. The role of the oxidative stress in cardiovascular diseases in patients with renal disease. Nefrologiya i dializ. 2004; 6 (2): 138–139. (In Russ.)]
  3. 3. Реутов В.П. Медико-биологические аспекты циклов оксид азота и супероксидного анион-радикала // Вестн. АМН Украины. – 2000. - № 3. – С. 35-41.
  4. 4. Andrew P.J., Mayer B. Enzymatic function of nitric oxide synthases Andrew P.J., Mayer B.//Cardiovasc. Res. – 1999. – 43. – P. 521-531.
  5. 5. Fatemeh S, Fahimeh A, Shohreh ZK, et al. The relationship between polymorphisms of Endothelial Nitric Oxide Synthase gene and recurrent abortion syndrome in Iranian female’s population. Pejouhandeh 2016;21:320–6.
  6. 6. Национальный клинический протокол «Профилактика и тактика ведения послеродовых акушерских кровотечений». Ташкент, 2021 г. С. 62.
  7. 7. Jansen Labby K, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Methylated N ω-hydroxy-l-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction. Biochemistry. 2013;52(18):3062–3073. https://doi. org/10.1021/bi301571v
  8. 8. Jaslow CR, Carney JL, Kutteh WH. Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertil Steril 2010;93:1234–43.
  9. 9. Kalinowski L, Janaszak-Jasiecka A, Siekierzycka A, Bartoszewska S, Woźniak M, Lejnowski D, et al. Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs. Cell Mol Biol Lett. 2016;21(1):16.

Most read articles by the same author(s)