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Abstract

Cervical cancer (CC) is one of the most common malignant tumors in women, with 604,000 new cases and 342,000 deaths in 2021 (1). Carcinoma of the cervix is the fourth most common health problem worldwide among women (2). Carcinoma cervix is caused by human papilloma virus (HPV), which is the most common sexually transmitted infection, has been shown to be related to UCC. This study was carried out in Laboratories of the College of Science/ Department of Biology and in a local lab during the period between December 2021 to August 2022.  The study of PCR was used to detection HOXB4 expression. We aimed to describe the histological changes of tumors malignant and benign and normal tissues of the cervical and determine the relationships between HOXB4 expression with the histopathological variables involving, stage, grade, muscle and lymph nodes invasiveness and histological types. results shows the values of HOXB4 expression and a significant difference (P-value>0.001) between patients with cervical cancer and control group, these results regarding the values means of HOXB4expression a significant difference (P-value=0.021) between patients with benign tumor and the control and the values means of HOXB4 expression a significantly difference (P-value >0.001) between patients with cervical cancer and benign tumor.

Keywords

cervical cancer PCR HOXB4

Article Details

How to Cite
Hameed, Z. A., & Salem Mahood, A. K. (2024). HISTOLOGICAL AND MOLECULAR STUDY OF HOXB4 GENE IN CERVICAL CANCER AND BENIGN. Central Asian Journal of Medical and Natural Science, 5(1), 268-288. https://doi.org/10.17605/cajmns.v5i1.2312

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