SYNTHESIS, CHARACTERIZATION, AND STUDY OF BIOLOGICAL ACTIVITY OF OXAZEPINE COMPOUNDS DERIVED FROM 1,3,4-OXADIAZOLE

Maha Mahdi Saleh; Fawzi Hamid Juma

doi:10.17605/cajmns.v5i1.2307

Maha Mahdi Saleh Department of Chemistry / College of Education for Women / Tikrit University
Fawzi Hamid Juma Department of Chemistry / College of Education for Women / Tikrit University

DOI: https://doi.org/10.17605/cajmns.v5i1.2307

Keywords: Oxazepine, Schiff base, Hydrazide, Biological activity, Escherichia coli, Staphylococcus aureus

Abstract

This study involves the synthesis of pentagonal rings of oxazepine derivatives through the reaction of one mole of hydrazide base derivatives with two moles of malic anhydride. The validity of the compound structures was confirmed using physical and spectroscopic methods such as UV-Vis. spectroscopy, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy. Additionally, melting points and purity were determined, and reaction progress was monitored by Thin-Layer Chromatography (TLC). The impact of some prepared compounds on the growth of two bacterial isolates, one Gram-negative (Escherichia coli) and the other Gram-positive (Staphylococcus aureus), was studied. Antibiotics amoxicillin, ampicillin, and ciprofloxacin were used as controls, and some of the prepared compounds showed good inhibitory effectiveness against the tested bacteria.

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