EVALUATING THE RESULTS OF OBESITY IN CHILDREN AGED 8 TO 14 YEARS ACCORDING TO MAGNESIUM LEVELS

Dr. Hanan Nabeel  Khalaf; Dr. Ruaa Salah  Mahdi; Dr. Ruaa Salah  Mahdi; Dr. Hasan Salih  Qadoori

doi:10.17605/cajmns.v4i6.2263

Dr. Hanan Nabeel Khalaf M.B.Ch.B., C.A.B.P. \ (Pediatric) Iraqi Ministry of Health, Baghdad Al-Karkh Health Directorate, Karkh Hospital for Child Birth, Baghdad, Iraq
Dr. Ruaa Salah Mahdi M.B.Ch.B., F.I.C.M.S. \ (Pediatric) Iraqi Ministry of Health, Baghdad Al-Karkh Health Directorate, Karkh Hospital for Child Birth, Baghdad, Iraq
Dr. Ruaa Salah Mahdi M.B.Ch.B., F.I.C.M.S. \ (Pediatric) Iraqi Ministry of Health, Baghdad Al-Karkh Health Directorate, Karkh Hospital for Child Birth, Baghdad, Iraq
Dr. Hasan Salih Qadoori M.B.Ch.B., C.A.B.P. \ (Pediatric) Iraqi Ministry of Health, Baghdad Al-Karkh Health Directorate, Karkh Hospital for Child Birth, Baghdad, Iraq

DOI: https://doi.org/10.17605/cajmns.v4i6.2263

Keywords: Obesity, Children

Abstract

Background In developed countries, it is a public health problem that affects both adults and children. Objective: This study aimed to assess health outcomes related to children with obese according to magnesium levels. Patients and method 120 samples were recruited, and clinical data were collected from one year, from January 2022 to February 2023. All examinations and laboratory tests were performed on the children, which included two groups, the first of which included children suffering from obesity and the second group of children of normal weight. Magnesium levels were assessed based on the degree of obesity and defined for children for all levels of obesity for both groups. Also, the general health of children was evaluated based on the quality-of-life scale. Results This study measured the levels of several biochemical markers in morbidly obese children. The recorded values were as follows: serum magnesium (1.6 ± 0.41), total cholesterol (188.46 ± 26.32), LDL-cholesterol (141.3 ± 27.11), triglycerides (108.46 ± 16.28), HDL-cholesterol (50.66±8.3).

In contrast, this research discovered that the biochemical rates of children with a healthy weight exhibited Serum magnesium levels of 2.5 ± 0.2, Total cholesterol levels of 131.60 ± 29.7, Triglyceride levels of 93.42 ± 23.60, and HDL-cholesterol levels of 58.72 ± 12.84. The blood pressure readings showed notable disparities between the two groups. In the group of morbidly obese children, the average Systolic Blood Pressure (BP) was 57.60 ± 12.3, and the average Diastolic BP was 61.86 ± 9.86. In contrast, the group of normal-weight children had an average Systolic BP of 46.33 ± 8.5 and an average Diastolic BP of 58.2 ± 11.6. Conclusion Most of obese children had a considerable drop in magnesium levels.

References

1. Ogden C, Carroll M, Curtin L, Lamb M, Flegal K. Prevalence of high body mass index in US children and adolescents, 2007–2008. JAMA 2010;303:242–9.
2. El-Zanaty Fatma, Way Ann. Egypt demographic and health survey 2008. Cairo, Egypt: Ministry of Health, El-Zanaty and Associates, and Macro International; 2009.
3. Manyanga T, El-Sayed H, Doku DT, Randall JR. The prevalence of underweight, overweight, obesity and associated risk factors among school-going adolescents in seven African countries. BMC Public Health 2014;14:887.
4. Gungor NK. Overweight and obesity in children and adolescents. J Clin Res Pediatr Endocrinol 2014;6 (3):129–43.
5. American Academy of Child and Adolescent Psychiatry (AACAP). Obesity in Children and Teens. Facts for Families 2011;79:3/11.
6. Bhalavi V, Deshmukh P, Atram M, Mahajan B. Study of hypertension and hyperlipidemia in the adolescent of central India. Int J Recent Trends Sci Technol 2014;10 (3):495–8.
7. Niranjan G, Anitha D, Srinivasan AR, Velu VK, Venkatesh C, Babu MS, et al. Association of inflammatory sialoproteins, lipid peroxides, and serum magnesium levels with cardiometabolic risk factors in obese children of South Indian population. Int J Biomed Sci 2014;10 (2):118–23.
8. Singla P, Bardoloi A, Parkash AA. Metabolic effects of obesity: a review. World J Diabetes 2010;1(3):76–88.
9. Charradi K, Elkahoui S, Limam F, Aouani E. High-fat diet-induced oxidative stress in white adipose tissue and disturbed plasma transition metals in the rat: prevention by grape seed and skin extract. J Physiol Sci 2013;63 (6):445–55.
10. Vehkala L, Ukkola O, Kesa¨niemi YA, Ka¨ho¨nen M, Nieminen A, Jula A, et al. Plasma IgA antibody levels to malondialdehyde acetaldehyde-adducts are associated with inflammatory mediators, obesity, and type 2 diabetes. Ann Med 2013;45 (8):501–10.
11. Arsaln N, Erdur B, Aydin A. Hormones and cytokines in childhood obesity. Indian Pediatr 2010;47 (10):829–39.
12. Dietary magnesium and genetic interactions in diabetes and related risk factors: a brief overview of current knowledge. Hruby A, McKeown NM, Song Y, et al. Nutrients. 2013;5:4990–5011.
13. Inoue I. Lipid metabolism and magnesium. Clin Calcium 2005;15 (11):65–79.
14. Rosolova H, Mayer Jr O, Reaven GM. Insulin-mediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Metabolism 2000;49 (3):418–20.
15. Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr 2013;4:378S–83S.
16. Sui X, Church TS, Meriwether RA. Uric acid and the development of metabolic syndrome in women and men. Metabolism 2008;57: 845–52.
17. Huerta MG, Roemmich JN, Kington ML, Bovbjerg VE, Wettman YF, Holmes YF, et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care 2005;28: 1175–81.
18. Kurpad AV, Aeberli I. Low serum magnesium and obesity – causal role or diet biomarker? Indian Pediatr 2012;49:100–1.
19. Lower serum magnesium concentration is associated with diabetes, insulin resistance, and obesity in South Asian and white Canadian women but not men. Bertinato J, Wu Xiao C, Ratnayake WM, et al. Food Nutr Res. 2015;59:25974.
20. Witkowski M, Hubert J, Mazur A. Methods of assessment of magnesium status in humans: a systematic review. Magnes Res 2011;24:163–80.
21. Vitamin D in pediatric patients with obesity and arterial hypertension. Radulović Ž, Zupan ZP, Tomazini A, Varda NM. Sci Rep. 2021;11:19591.
22. Ghalli I, Salah N, Hussien F, Erfan M, El-Ruby M, Mazen I, et al. Egyptian growth curves 2002 for infants, children, and adolescents. In: Sartorio A, Buckler JMH, Marazzi N, editors. Crescere nel mondo. Italy: Ferring publisher; 2008.
23. Serum magnesium in overweight children. Jose B, Jain V, Vikram NK, et al. http://www.indianpediatrics.net/feb2012/109.pdf. Indian Pediatr. 2012;49:109–112.
24. Maqbool A, Olsen IE, Stallings VA. Clinical assessment of nutritional status. In: Duggan C, Watkins JB, Walker WA, editors. Nutrition in pediatrics: basic science and clinical applications. 4th ed. Hamilton, Ontario: BC Becker Inc.; 2008. p. 5–13.
25. Phillips S, Edlbeck A, Kirby M, Goday P. Ideal body weight in children. Nutr Clin Pract 2007;22 (2):240–5.
26. Serum magnesium concentrations in the Canadian population and associations with diabetes, glycemic regulation, and insulin resistance. Bertinato J, Wang KC, Hayward S. Nutrients. 2017;9:296.
27. Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial. Joris PJ, Plat J, Bakker SJ, et al. Am J Clin Nutr. 2016;103:1260–1266.
28. Serum magnesium concentrations in the Canadian population and associations with diabetes, glycemic regulation, and insulin resistance. Bertinato J, Wang KC, Hayward S. Nutrients. 2017;9:296.
29. Relationship between selected serum metallic elements and obesity in children and adolescents in the U.S. Fan Y, Zhang C, Bu J. Nutrients. 2017;9:104.
30. Ul-Haq Z, MacKay DF, Fenwick E, Pell JP. Meta-Analysis of the Association between Body Mass Index and Health-Related Quality of Life among Children and Adolescents, Assessed Using the Pediatric Quality of Life Inventory Index. J Pediatr. 2013;162:280–286.