Synthesis and Study of the Biological Activity of Some Oxazepine Containing the Pyrrolidine Ring
Keywords:
Pyrrolidine, Thiosemicarbazide, Oxazepine, heterocyclic rings
Abstract
In this study, amine compounds (HA1, HA2) were prepared. Schiff bases (HA3-HA6) were prepared by reacting amine compounds with benzaldehyde substitutes. Oxazepane derivatives (HA7-HA10) were prepared by reacting Schiff bases with phthalic anhydride. Characterization by using melting point, TLC, FT-IR, 1H-NMR, and 13C-NMR. The biological activity of some of the prepared compounds was evaluated.
References
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2. Flaherty, P. T. (2007). Heterocyclic Chemistry at a Glance By John A. Joule and Keith Mills. Blackwell Publishing, Oxford, UK 2007. vii+ 150 pp. 21× 19.5 cm. ISBN 9781405139182.£ 17.99.
3. Makosza, M. (1991). Vicarious nucleophilic substitution of hydrogen in the chemistry of heterocyclic compounds. Synthesis, 1991(02), 103-111.
4. Jackman, L. M., & Sternhell, S. (2013). Application of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry: International Series in Organic Chemistry (Vol. 10). Elsevier.
5. Dalaf, A. H., Jumaa, F. H., & Yass, I. A. (2022, November). Synthesis, characterization, biological evaluation, molecular docking, assess laser efficacy, thermal performance and optical stability study for new derivatives of bis-1, 3-oxazepene and 1, 3-diazepine. In AIP Conference Proceedings (Vol. 2394, No. 1, p. 040037). AIP Publishing LLC.
6. Dalaf, A. H., & Jumaa, F. H. (2020). Synthesis, Identification and Assess the Biological and Laser Efficacy of New Compounds of Azetidine Derived from Benzidine. Muthanna Journal of Pure Science (MJPS), 7(2):12-25.
7. Yass, I. A., Aftan, M. M., Dalaf, A. H., & Jumaa, F. H. (Nov. 2020). Synthesis and Identification of New Derivatives of Bis-1,3-Oxazepene and 1,3-Diazepine and Assess the Biological and Laser Efficacy for Them. The Second International & The Fourth Scientific Conference of College of Science – Tikrit University. (P4): 77-87. Alasadi, Y. K., Jumaa, F. H., & Dalaf, A. H. (2022, November). Synthesis, identification, antibacterial activity and laser effect of new derivatives of bis-1, 3-oxazepene-4, 7-dione and 1, 3-diazepine-4, 7-dione. In AIP Conference Proceedings (Vol. 2394, No. 1, p. 040019). AIP Publishing LLC.
8. Toma, M. A., Ibrahim, D. A., Dalaf, A. H., Abdullah, S. Q., Aftan, M. M., & Abdullah, E. Q. (2022, November). Study the adsorption of cyclopentanone on to natural polymers. In AIP Conference Proceedings (Vol. 2394, No. 1, p. 040007). AIP Publishing LLC.
9. Hamad, A. M., Atiyea, Q. M., Hameed, D. N. A., & Dalaf, A. H. (2023). Green synthesis of copper nanoparticles using strawberry leaves and study of properties, anti-cancer action, and activity against bacteria isolated from Covid-19 patients. Karbala International Journal of Modern Science, 9(1), 12.
10. Jassim, A. S., Dalaf, A. H., and Abdullah. T. F. (2022). Studying the Biological Activity and Properties of Copper Nanoparticles Prepared by Pulsed Laser Ablation in Liquid. The Third International and The Fifth Scientific Conference for College of Science –Tikrit University, 1(25), 213-221.
11. Hamad, A. M., Atiyea, Q. M., Jwair, W. A., Dalaf, A. H., Jasim, A. S., El-Saigher S. M., Saad, Z. H., Mohammed. L. J. (2022). In vitro Comparison of the Effect of Zinc Oxide Nanoparticles and Hibiscus sabdariffa Extract on Streptococcus mutans Isolated from Human Dental Caries. The Third International and The Fifth Scientific Conference for College of Science –Tikrit University, 2(02), 213-221.
12. Balouiri, M., Sadiki, M., & Ibnsouda, S. K. (2016). Methods for in vitro evaluating antimicrobial activity: A review. Journal of pharmaceutical analysis, 6(2), 71-79.
13. Gonelimali, F. D., Lin, J., Miao, W., Xuan, J., Charles, F., Chen, M., & Hatab, S. R. (2018). Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Frontiers in microbiology, 9, 1639.
14. Dalaf, A. H. (2018). Synthesis and Characterization of Some Quartet and Quinary Hetero cyclic Rings Compounds by Traditional Method and Microwave Routes Method and Evaluation of Their Biological Activity. M.Sc. Thesis, Tikrit University, Tikrit, Iraq: 1-94 pp.
15. Dalaf, A. H., & Jumaa, F. H. (2018). Synthesis, Characterization of some 1,3-Oxazepane -4,7-Dione by Traditional and Microwave routes method and evaluation of their biological activity. Al-utroha for Pure Science. (8): 93-108.
16. Dalaf, A. H., Jumaa, F. H., & Jabbar, S. A. S. (2018). Synthesis and Characterization of some 2, 3-dihydroquinozoline and evaluation of their biological activity. Tikrit Journal of Pure Science, 23(8): 66-67.
17. Salwa, A. J., Ali, L. H., Adil, H. D., Hossam, S. A. (2020). Synthesis and Characterization of Azetidine and Oxazepine Compounds Using Ethyl-4-((4-Bromo Benzylidene) Amino) Benzoate as Precursor and Evalution of Their Biological Activity. Journal of Education and Scientific Studies, ISSN: 24134732. 16(5): 39-52.
18. Abd, I. Q., Ibrahim, H. I., Jirjes, H. M., & Dalaf, A. H. (2020). Synthesis and Identification of new compounds have Antioxidant activity Beta-carotene, from Natural Auxin Phenyl Acetic Acid. Research Journal of Pharmacy and Technology, 13(1): 40-46.
19. Saleh, R. H., Rashid, W. M., Dalaf, A. H., Al-Badrany, K. A., & Mohammed, O. A. (2020). Synthesis of Some New Thiazolidinone Compounds Derived from Schiff Bases Compounds and Evaluation of Their Laser and Biological Efficacy. Ann Trop & Public Health, 23(7): 1012-1031.
20. Salih, B. D., Dalaf, A. H., Alheety, M. A., Rashed, W. M., & Abdullah, I. Q. (2021). Biological activity and laser efficacy of new Co (II), Ni (II), Cu (II), Mn (II) and Zn (II) complexes with phthalic anhydride. Materials Today: Proceedings, 43, 869-874.
21. Aftan, M. M., Jabbar, M. Q., Dalaf, A. H., & Salih, H. K. (2021). Application of biological activity of oxazepine and 2-azetidinone compounds and study of their liquid crystalline behavior. Materials Today: Proceedings, 43, 2040-2050.
22. Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings, 45, 5529-5534.
23. Aftan, M. M., Toma, M. A., Dalaf, A. H., Abdullah, E. Q., & Salih, H. K. (2021). Synthesis and Characterization of New Azo Dyes Based on Thiazole and Assess the Biological and Laser Efficacy for Them and Study their Dyeing Application. Egyptian Journal of Chemistry, 64(6), 2903-2911.
24. Khalaf, S. D., Ahmed, N. A. A. S., & Dalaf, A. H. (2021). Synthesis, characterization and biological evaluation (antifungal and antibacterial) of new derivatives of indole, benzotriazole and thioacetyl chloride. Materials Today: Proceedings. 47(17), 6201-6210.
25. Dalaf, A. H., Jumaa, F. H., & Salih, H. K. (2021). Preparation, Characterization, Biological Evaluation and Assess Laser Efficacy for New Derivatives of Imidazolidin-4-one. International Research Journal of Multidisciplinary Technovation, 3(4), 41-51.
26. Dalaf, A. H., Jumaa, F. H., & Salih, H. K. (2021). MULTIDISCIPLINARY TECHNOVATION. Red, 15(A2), C44H36N10O8.
27. Dalaf, A. H., Jumaa, F. H., Aftana, M. M., Salih, H. K., & Abd, I. Q. (2022). Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole. In Key Engineering Materials (Vol. 911, pp. 33-39). Trans Tech Publications Ltd.
28. Alasadi, Y. Kh., Jumaa, F. H., Dalaf, A. H., Shawkat, S. M., & Mukhlif, M. Gh. (2022). Synthesis, Characterization, and Molecular Docking of New Tetrazole Derivatives as Promising Anticancer Agents. Journal of Pharmaceutical Negative Results. 13(3): 513-522.
29. Kovács, A., Vasas, A., & Hohmann, J. (2008). Natural phenanthrenes and their biological activity. Phytochemistry, 69(5), 1084-1110.
Published
2023-11-30
How to Cite
Hamad, A. S., Shnak, Q. A., & Ali, M. H. (2023). Synthesis and Study of the Biological Activity of Some Oxazepine Containing the Pyrrolidine Ring. Central Asian Journal of Medical and Natural Science, 4(6), 806-816. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2131
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