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Abstract





: Background: Diabetes is represented as one of the most common and fastest prevalences in the world that expected to effect 693 million during 2045.


Objective: Our study aimed to assess the role of a genetic factor in patients who have diabetes.


Patients and methods We collected our data utilizing all relevant clinical and demographic parameters associated with different hospitals in Iraq, spanning from 16th June 2022 to 25th April 2023. Our research centred around patients of both genders, ranging between the ages of 23 and 50.  In order to develop the methodology, patient data was grouped based on the correlation between gene type and diabetes type, as well as specific SNP markers associated with each gene. Additionally, we analysed the impact of risk factors on patients in both observed and predicted status, including total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. Furthermore, we explored the current correlation with genetic factors in diabetes patients. The SPSS program analysed our results, and we used Classify modelling, Linear regression model, nearest neighbor model, decision tree regression, and Q-Q figure plotting to predict the future impact of genetic factors and determine which gene led to high rates of diabetes among patients.






Results and discussion of the findings show that the percentage of cases with the AFF3 gene was high at 45%, whereas the ENPP7 gene was found in 27% of cases. Patients with high cholesterol levels had a total cholesterol level of 204.8 (mg/dL) and a low level of 175.10 (mg/dL). Similarly, patients with high triglyceride levels had a level of 197






(mg/dL) and a low level of 160.2 (mg/dL). Additionally, patients with low HDL cholesterol levels had 139.02 (mg/dL) and those with high levels had 144 (mg/dL), while patients with low LDL cholesterol levels had 135 (mg/dL) and those with high levels had 157 (mg/dL). Among these, the nearest neighbor model proved the most accurate, revealing that LDL cholesterol has the least importance, while HDL cholesterol holds the most significance.


Conclusions Our finding showed a linear correlation between the AFF3 gene and diabetes prevalence, with our predictive analysis revealing a negative effect of the AFF3 gene type on patients with diabetes.


 





Keywords

Genetic factor; HDL, LDL, Total Cholesterol; Triglycerides; and Diabetes.

Article Details

How to Cite
Khaleel Ibrahim Ismael, Mustafa Faeq Kazem Hussein, & Abbas AbdulWahhab Jumaah Al-Salihi. (2023). The Effect of Genetics on The Prevalence of Diabetes in Patients. Central Asian Journal of Medical and Natural Science, 1-13. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2034
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