Main Article Content


Burn injury is the most severe of all types of injuries, causing multiple and long-term disorders of homeostasis, leading to dysfunction of organs and systems. The most important link in local treatment is the effect on the microflora. A burn wound needs antibacterial therapy from the moment of onset until its complete closure, since colonization by microorganisms with the development of purulent inflammation leads to severe intoxication, prevents the healing of epidermal and subdermal burns, leads to deepening of burn wounds, lysis and rejection of autoderm grafts, and serves as a source of generalization of infection


intoxication experiment epidermis dermis oxidants

Article Details

How to Cite
Sultanbaev Sh.A, Korzhavov Sh.O, Ochilov S.A, & Sarapina V.A. (2021). DYNAMICS OF DEVELOPMENT OF ENDOGENOUS INTOXICATION IN EXPERIMENTAL THERMAL BURN. Central Asian Journal of Medical and Natural Science, 2(3), 182-185.


  1. 1. Aripov A.N., Fesenko L.M. Clinical biochemistry. Methods // Publishing house of medical literature named after Abu Ali ibn Sino. - 2010 .-- p. 59-61.
  2. 2. Afanasyeva, A.N. Comparative assessment of the level of endogenous intoxication in persons of different age groups A. N. AfanasyevaKlin. lab. diagn. 2016.-№6.-p. 11-12.
  3. 3. Vikhriev V.S., Malakhov S.F., GurevichK.Ya. The first experience of using massive hardware plasmapheresis in the complex treatment of burn disease // Tech. report III All-Union. conf. "Modern means of first aid and methods of treatment of burn disease", - M., 2016, p. 149 - 150.
  4. 4. Inchina VI, Zorkina AV, Erofeeva MV, Morozov M. Yu. Prospects for the use of antioxidants in clinical medicine // Science and innovations in the Republic of Mordovia: Materials of the IV Republican scientific-practical. conf. (December 22-24, 2014). - Saransk, 2015 .-- P. 367 - 370.
  5. 5. Korobeinikova E.N. modification of the determination of the products of lipid peroxidation in the reaction with thiobarbituric acid.//Laboratory.-2019.-P.8-10.
  6. 6. Marchuk AI, Zaets TL, Stankevich VE Extracorporeal detoxification methods for burn disease // Kazan. honey. zhurn. - 1989, T.70, N 6, p. 447 - 451.
  7. 7. PovstyanoyN.Ye., Kozinets G.P., Sosyura T.V. The effectiveness of extracorporeal connection of the pig spleen in early and late septic complications in patients with burns // Klin. surgery, 2010, N 3, p. 9 - 13.
  8. 8. Tugaybaev G.S. et al. Method for determining the sorption capacity of erythrocytes // Laboratory work. - 2011. - No. 3. - S. 32-34.
  9. 9. Santos X., Castilla C., Martin M. et al. Role of leukotrienes in the physiopathology of the response to experimental burn. Ann. of burns and fire disasters, v.XIV - n.2- p.90-93, June 2020.
  10. 10. Williams B.G., Blattner F.R., 2010. Bacteriophage λ vector for DNA cloning. In: Genetic engineering (Setlow J.K. and Hollaender A., ads.), vol. 2, p. 201, Plenum Press, New York.