Molecular Mechanisms of Periodontitis Development in Patients with Insulin Resistance and Ways of Its Treatment

Komilova Adiba Zakirzhonovna; Hadzhimetov Abdugafur Akhatovich; Usmanova Shoira Ravshanbekovna

Komilova Adiba Zakirzhonovna TASHKENT STATE DENTAL INSTITUTE
Hadzhimetov Abdugafur Akhatovich
Usmanova Shoira Ravshanbekovna

Keywords: insulin-dependent diabetes, insulin resistance, chronic generalized periodontitis.

Abstract

The analysis of modern data on the molecular mechanisms of the development and progression of insulin-dependent diabetes is presented. The leading role of HSP72 reduction in pancreatic cells and target organs for insulin in disorders of the structure of insulin molecules, its receptor perception, and mitochondrial functioning in DM2 is substantiated. New approaches to the treatment of DM2 have been discussed and proposed. Periodontitis in patients with diabetes mellitus has the same forms according to the clinical course, severity of manifestations, ontogenetic characteristics, and prevalence as in persons suffering from periodontitis, but not having diabetes mellitus. However, periodontitis in patients with diabetes mellitus, according to many authors, is poorly treatable and has an unfavorable prognosis.

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