Synthesis, Identification, and Antibacterial Effect Assessment of Some New Pyrazoline and 4,5-Dihydroisoxazole Compounds Derived from Substituted Dicinnamyle Acetone
Keywords:
dicinnamylidene acetone, pyrazoline, isoxazoline, 4,5-dihydroisoxazole, Escherichia coli, staphylococcus
Abstract
A number of novel heterocyclic compounds were prepared, specifically pyrazoline compounds (A1-5), 4,5-dihydroisoxazole compounds (B1-5), derived from 1,9-Diphenyl-1,3,6,8-nonatetraen-5-one and its substitutes. These compounds have important uses in the fields of organic, medical and pharmaceutical chemistry. The prepared compounds were characterized using (FT-IR), (1H-NMR), (13C-NMR) techniques. Antibacterial activities of these compounds were proven against (Escherichia coli) and (staphylococcus) results were compared with ciprofloxacin, levofloxacin, and gentamicin.
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5. M. S. Muneera and J. Joseph, “Design, synthesis, structural elucidation, pharmacological evaluation of metal complexes with pyrazoline derivatives,” J. Photochem. Photobiol. B Biol., vol. 163, pp. 57–68, Oct. 2016, doi: 10.1016/j.jphotobiol.2016.08.010.
6. A. Mumtaz et al., “Investigation of potent inhibitors of cholinesterase based on thiourea and pyrazoline derivatives: Synthesis, inhibition assay and molecular modeling studies,” Bioorg. Chem., vol. 90, p. 103036, Sep. 2019, doi: 10.1016/j.bioorg.2019.103036.
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10. A. galaly and K. Maulood, “Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city,” Kirkuk Univ. Journal-Scientific Stud., pp. 0–0, Jun. 2023, doi: 10.32894/kujss.2023.137833.1093.
11. N. Tapabashi, N. Taha, and M. El-Subeyhi, “Synthesis and Characterization of Some New Azo-Schiff Bases as Energy Rich Candidate Compounds Derived from 1, 5-Diaminoanthraquinone by Fusion Method,” Kirkuk Univ. Journal-Scientific Stud., vol. 16, no. 2, pp. 51–63, Jun. 2021, doi: 10.32894/kujss.2021.168662.
12. S. D. L. Holman et al., “Electrochemical Synthesis of Isoxazolines: Method and Mechanism,” Chem. – A Eur. J., vol. 28, no. 13, Mar. 2022, doi: 10.1002/chem.202103728.
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14. K. Husain, M. Abid, and A. Azam, “Novel Pd(II) complexes of 1-N-substituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity,” Eur. J. Med. Chem., vol. 43, no. 2, pp. 393–403, Feb. 2008, doi: 10.1016/j.ejmech.2007.03.021.
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Published
2023-09-26
How to Cite
Baker, A. T., & Jasim, S. S. (2023). Synthesis, Identification, and Antibacterial Effect Assessment of Some New Pyrazoline and 4,5-Dihydroisoxazole Compounds Derived from Substituted Dicinnamyle Acetone. Central Asian Journal of Medical and Natural Science, 4(5), 239-254. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1812
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Articles
