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The research presents the results of a comprehensive immunomorphological study in thymus autoimplantation. Using morphological and immunological research methods, was assessed the state of the epithelial reticular stroma of the thymus in experimental Chinchilla rabbits. The clinical and immunological effects of the influence of autoimplantation on the stages of experimental research have been established


thymus autoimplantation rabbits immunology

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How to Cite
Navruzova Sh.I, & Akhmedov A.T. (2021). AUTOIMPLANTATION OF THYMUS IN SURGICAL CORRECTION OF CONGENITAL HEART DEFECTS . Central Asian Journal of Medical and Natural Science, 2(3), 88-98.


  1. BudchanovYu.I. Cellular immunity. types of cellular cytotoxicity. receptors and markers, lymphocyte subpopulations. Teaching aid on general immunology. Tver 2008.-11s.
  2. Donetskova A.D., Frolenko A.L., Troshina V.V. Thymus excision rings in peripheral blood lymphocytes. Age dynamics and influence of thymectomy // Immunology. 2010. No. 6. S. 293-298.
  3. Dudarev I.V. Immunological and hemodynamic characteristics of children with congenital heart defects of the blue and pale type // Immunology. - 2002. - T. 23. - No. 3. - P. 167-170.
  4. Features of the formation of the immune system among children with congenital heart disease VA Chetvertnykh, NP Loginova, DY Shilov, AP Godovalov, OV Lebedinskaya, EV Saydakova // Bulletin of the Perm Scientific Center 3/2013, 67-78 p.
  5. Frolenko A.L. Clinical and immunological characteristics of children after thymectomy: author. diss. Ph.D. Orenburg, 2011.26 p.
  6. Gorbunov VV Everything about rabbits: breeding, maintenance, care. // Practical guide // "AST Publishing House" 2015.
  7. Lebedev M.Yu., Sholkina M.N., Novikov D.V., Shumilova S.V., Novikov V.V., Karaulov A.V. Serum content of soluble CD25 and CD95 molecules in burn patients. Bulletin of the Russian Academy of Medical Sciences. 2017; 72 (4): 276-281. doi: 10.15690 / vramn772)].
  8. Loginova N.P., Chetvertnykh V.A., Chemurzieva N.V. Immunomorphological processes in the thymus with congenital heart disease in children // Bulletin of new medical technologies. Electronic edition. 2018. No. 4. Publication 3-15. URL: (date accessed: 13.07.2018). DOI: 10.24411 / 2075-4094-2018-16134.
  9. Loginova N.P., Chetvertnykh V.A., Semchenko V.V., Saidakova E.V., Chemurzieva N.V. Features of the expression of cytokeratins 5 and 8 in the cells of the epithelial stroma of the thymus and the amount of TREC in peripheral T-lymphocytes in children with congenital heart defects // Immunology. 2014.Vol. 35, No. 6. S. 333–337.
  10. Lukyanova L.D., Kirova Yu.I., Sukoyan G.V. New about signaling mechanisms of adaptation to hypoxia and their role in systemic regulation // Pathogenesis. 2011.Vol. 9, No. 3. S. 4-14.
  11. Nuraliev N.A., Bektimirov A.M.-T., Alimova M.T., SuvonovK.Zh. Rules and methods of working with laboratory animals in experimental microbiological and immunological research // Methodical manual. - Tashkent, 2016 .-- 33 p.
  12. Prelog M., Keller M., Geiger R. Thymectomy in early childhood: Significant alterations of the CD4 + CD45RA + CD62L + T cell compartment in later life // J. Clinical Immunology. 2009. Vol. 130. P. 123-132.
  13. Teodorczyk-Injeyan JA, McRitchie DI, Peters WJ, et al. Expression and secretion of IL-2 receptor in trauma patients. Ann Surg. 1990; 212 (2): 202-208. doi: 10.1097 / 00000658-199008000-00015.
  14. Van Gent R., Schadenberg AWL, Otto SA, Nievelstein RAJ, Sieswerda GT Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration? // Blood. 2011. Vol. 118, no. 3. P. 627-634.
  15. Walsh DS, Siritongtaworn P, Pattanapanyasat K, et al. Lymphocyte activation after non-thermal trauma. Br J Surg. 2000; 87 (2): 223-230.doi: 10.1046 / j.1365-2168.2000.01341.x.
  16. Yarilin A.A. Immunology. - M .: GEOTAR-Media, 2010 .-- 752 p.
  17. Zinkovsky M.F. Congenital heart defects. Kiev: "Book Plus", 2009.