Synthesis and Characterization of New 2-Thiophen 3'4-Dimethylbenzaldehyde as 3,4-Dihydropyrimidinone Derivatives

  • Lina Abdullah Naser Southern Technical University, Nasiriyah Technical Institute Nursing technology department, Iraq
Keywords: Biginilli reaction with 3,4-dihydropyrimidine-2-(1H)-ones


Background: This study it has been successfully synthesized and characterized in the form of [3,4-dihydropyrimidin-2-(1H) ones] (1-3) a derivative. This compound were synthesized by reaction of 1,3-cyclohexane dione in the presence of ethanol, urea, and aromatic aldehyde(t-BuOK).It has been characterized spectroscopically (For example, 13C-NMR, 1H-NMR, and FT-IR) For the purpose of showing the chemical composition and the final result of the industrial compound.

Methods: The design of this research was cross-sectional. descriptive investigation,which included the preparation of a group of polypyrimidine derivatives.

Results: In the current work, 1,3-cyclohexandione, aromatic aldehydes, and urea are combined with ethanol to create 3,4-Dihydropyrimidine. The chemical composition of molecules was determined via spectral analysis (1-2)a.

Conclusion: When t-BuOK was used as a catalyst in this work to create three DHMP compounds, it produced outstanding results with a high yield and a quicker reaction time than the assistant factor.


1. Domling,A.; Ugi, I. Angew. Chem., Int. Ed. 2000, 39, 3168.
2. Weber, L.; lllgen, K.; Almstetter, M. Synlett 1999, 3, 366.
3. Biginelli, P. Gazz. Chim. Ital. 1893, 23, 360.
4. Rovnyak,G.C.Kimball,S.D.Beyer B.Cucinotta,G.DiMarco, J. D.Gougoutas, J. Z.Hedberg,A.Malley,M.F.McCarthy,J. P. Zhang, R.Moreland,S.J.Med. Chem. 1995, 38, 119 and references therein.
5. D.S.Bose,M.Sudharshan,S.W. Chavhan.Organic Chemistry Division III, Fine Chemicals Laboratory,Indian Institute of Chemical Technology, Hyderabad- 500 007, India ARKIVOC 2005 (iii) 228-236 .
6. M.M. Hosseini1.E.Kolvari1.N.Koukabi1.M.Ziyaei1.M.Zolfigol. 28 February 2016- Springer Science+Business Media New York 2016
7. Cepanec, I. Litvić, M.Filipsn‐Litvić, M. Grüngold,I,2007,J. Tetrahedron,63, 11822.
8. Chitra, S. Pandiarajan, K., 2009, J. Tetrahedron Lett, 50, 2222.
9. Lewis, R. W.; Mabry, J.; Polisar, J. G.; Eagen, K. P.; Ganem, B.; Hess, G. P,2010, J. Biochemistry, 49, 4841.
10. Al-Refai, M.Ibrahim,M.Al-Fawwaz,A.Geyer, A., 2017, J. European Journal of Chemistry, 8,1, 96-100.
11. Field,L. D. Sternhell,S. and Kalman, J. R., 2012, J. ''Organic structures from spectra'',John Wiley & Sons.
How to Cite
Naser, L. A. (2023). Synthesis and Characterization of New 2-Thiophen 3’4-Dimethylbenzaldehyde as 3,4-Dihydropyrimidinone Derivatives. Central Asian Journal of Medical and Natural Science, 4(5), 33-37.