Estimation of IL-17 and TNF-α serum concentrations in patient with proteus spp infection in Al-Najaf province, Iraq

Oday Mitib Hadi  zwain; Zahraa Hameed  Oda; Mustafa . R.M.AL-Fatlawi

Oday Mitib Hadi zwain Al-Furat Al-Awsat Technical University, College of Health & Medical tech., Kufa
Zahraa Hameed Oda Al-Furat Al-Awsat Technical University, College of Health & Medical tech., Kufa
Mustafa . R.M.AL-Fatlawi Al-Furat Al-Awsat Technical University, College of Health & Medical tech., Kufa

Keywords: Proteus spp, IL17, TNF-α

Abstract

Proteus spp infections are common in last period among people in Iraq. It may cause serious complications if left untreated. Proinflammatory cytokine Interleukin-17 (IL-17) is required for immunity against extracellular pathogens. Tumor necrosis factor-a (TNF- α) is a pleiotropic cytokine that plays an essential role in mediating inflammatory processes. This study aimed to investigate the role of IL- 17 and TNF-α in immunity against Proteus spp infection. A total of 90 serum sample toke from patient clinically confirmed with Proteus spp infection, the 90 sample is divided to three groups, case grope 30 sample (patient has Proteus spp infection),30 samples control positive group (patient with different type of bacterial infection) 30 samples control negative group (healthy indivisibles) were enrolled in this study. blood samples were collected in Alnajaf Alashrf hospitals in Najaf province, Iraq, during the period from November 2022 to Jun 2023. Cytokine profile was assessed using ELISA technique. Serum IL17 results showed a significant difference (P-value 0.001) between patients and controls grubs and serum TNF-α results also showed a significant difference (P-value 0.001) between patients and controls groups. It was concluded from the present study that Proteus spp infections caused strong influence on immune response and caused significant elevated in IL-17 and TNF-α.

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