Evaluation the Role of Vitamin B12 and Ferritin in Obese Patients Who Underwent Gastric Sleeve Surgery

  • Samar Jassim Ibrahim Department of Chemistry, College of Education for Girls, University of Mosul, Iraq
  • Lelas Farhan Bdaiwi Department of Chemistry, College of Education for Girls, University of Mosul, Iraq
  • Muthanna Asaad Al Sherbit Al-Jamhory Teaching Hospital , Nineveh Health Directorate, Mosul, Iraq
  • Yasser Fawzi Zidan Al-Jamhory Teaching Hospital , Nineveh Health Directorate, Mosul, Iraq
Keywords: Vitamin B12, Ferritin, Gastric Sleeve

Abstract

Background: Obesity is a public health problem and has led to advances in bariatric surgery. Laparoscopic sleeve gastrectomy (LSG) has become the most popular procedure worldwide; Due to continuous losing pounds and reducing obesity-related diseases. However, nutritional deficiencies are common due to altered digestive tract functions and anatomy, and poor absorption of micronutrients.

Objectives: To investigate after three months of bariatric surgery the levels of vitamin B12 and ferritin in patients who underwent bariatric surgery, we study the prevalence of micronutrient and vitamin deficiencies for the first (3) months before and after surgery, follow up the results of laparoscopic sleeve gastrectomy in terms of weight loss, obesity and comorbidities for obesity.

Materials and Methods: the analyzes were conducted for a group of 30 patients of both sexes who underwent sleeve gastrectomy and who were obese and had a body mass index of 40 kg / m2 or more. The study spanned from July 2022 to January 2023, after which they underwent sleeve gastrectomy in the hospital. Al-Zahrawi - Nineveh by specialized doctors and followed up for (3) months after the operation.

Results: the current study showed a significant decrease in vitamin B12, ferritin, hemoglobin, protein, albumin, creatinine, urea, sodium, potassium, and zinc levels in the serum of patients who underwent sleeve gastrectomy over the course of three months after the operation, compared with the serum of the same patients before. The results also showed a positive correlation between vitamin B12, ferritin, protein, and zinc. The results also showed a positive correlation between ferritin, vitamin B12, hemoglobin, and blood sugar.

Conclusion: The risk of developing vitamin b12 deficiency and iron deficiency after surgery due to insufficient intake and absorption of micronutrients, and patients who have undergone gastric sleeve surgery are at risk of developing micronutrient deficiencies, so nutritional supplements should be added, especially vitamin b12 and iron, and e. As gastrectomy included, BMI decreases in the long term.

References

1. Y. C. Chooi, C. Ding, and F. Magkos, “The epidemiology of obesity,” Metabolism., vol. 92, pp. 6–10, 2019, doi: 10.1016/j.metabol.2018.09.005.
2. D. E. Arterburn, D. A. Telem, R. F. Kushner, and A. P. Courcoulas, “Benefits and Risks of Bariatric Surgery in Adults: A Review,” JAMA - J. Am. Med. Assoc., vol. 324, no. 9, pp. 879–887, 2020, doi: 10.1001/jama.2020.12567.
3. R. Lupoli, E. Lembo, G. Saldalamacchia, C. Kesia, L. Angrisani, and B. Capaldo, “World Journal of Daibetes,” World J. Diabetes, vol. 8, no. 11, pp. 26–32, 2017.
4. A. M. Różańska-Walędziak et al., “Present trends in bariatric surgery in Poland,” Wideochirurgia I Inne Tech. Maloinwazyjne, vol. 14, no. 1, pp. 86–89, 2019, doi: 10.5114/wiitm.2018.77707.
5. L. Rawlins, M. P. Rawlins, C. C. Brown, and D. L. Schumacher, “Sleeve gastrectomy: 5-year outcomes of a single institution,” Surg. Obes. Relat. Dis., vol. 9, no. 1, pp. 21–25, 2013, doi: 10.1016/j.soard.2012.08.014.
6. M. Palermo and E. Serra, “Laparoscopic Sleeve Gastrectomy: How Do I Do It,” J. Laparoendosc. Adv. Surg. Tech., vol. 30, no. 1, pp. 2–5, 2020, doi: 10.1089/lap.2019.0452.
7. F. O’Leary and S. Samman, “Vitamin B12 in health and disease,” Nutrients, vol. 2, no. 3, pp. 299–316, 2010, doi: 10.3390/nu2030299.
8. Z. Nadeem, A. Mcintosh, and S. Lawrie, “Mental health Mental health,” Who, vol. 72, no. April, pp. 1500–1531, 2017, [Online]. Available: https://www.who.int/health-topics/mental-health#tab=tab_2
9. Getta HA., “Vitamin B12 deficiency without anemia in the middle- and old-aged population in Sulaymaniyah City,” Med J Babylon, vol. 17, no. 3, pp. 244–246, 2020, doi: 10.1016/j.ab.2009.02.029.
10. F. A. Marin, I. Rasera Junior, C. V. de S. Leite, and M. R. M. de Oliveira, “La ferritina en mujeres hipertensas y diabéticas antes y después de la cirugía bariátrica,” Nutr. Hosp., vol. 31, no. 2, pp. 666–671, 2015, doi: 10.3305/nh.2015.31.2.7629.
11. M. Volkers, “No TitleΕΛΕΝΗ,” Αγαη, vol. 8, no. 5, p. 55, 2019.
12. E. Of and T. H. E. Test, “LIAISON ® Ferritin ( [REF] 313551) 1.,” vol. 12, no. Vc, pp. 6–11, 2022.
13. P. R. Hinton, “Statistics Explained: A Guide for Social Science Students,” 2nd ed. Routledge, 2004. doi: https://doi.org/10.4324/9780203496787.
14. E. C. Krzizek, J. M. Brix, A. Stöckl, V. Parzer, and B. Ludvik, “Prevalence of Micronutrient Deficiency after Bariatric Surgery,” Obes. Facts, vol. 14, no. 2, pp. 197–204, 2021, doi: 10.1159/000514847.
15. K. E. Behrns, C. D. Smith, and M. G. Sarr, “Prospective evaluation of gastric acid secretion and cobalamin absorption following gastric bypass for clinically severe obesity,” Dig. Dis. Sci., vol. 39, no. 2, pp. 315–320, 1994, doi: 10.1007/BF02090203.
16. T. A. Ponsky, F. Brody, and E. Pucci, “Alterations in gastrointestinal physiology after Roux-en-Y gastric bypass,” J. Am. Coll. Surg., vol. 201, no. 1, pp. 125–131, 2005, doi: 10.1016/j.jamcollsurg.2005.03.021.
17. A. Al-Mutawa, S. Al-Sabah, A. K. Anderson, and M. Al-Mutawa, “Evaluation of Nutritional Status Post Laparoscopic Sleeve Gastrectomy—5-Year Outcomes,” Obes. Surg., vol. 28, no. 6, pp. 1473–1483, 2018, doi: 10.1007/s11695-017-3041-7.
18. G. Saleh and L. F. Bdaiwi, “Biochemical study of hepcidin and Interleukin_6 in the serum of patients with Down syndrome in Nineveh Governorate,” Egypt. J. Chem., vol. 66, no. 2, pp. 191–198, 2023, doi: 10.21608/ejchem.2022.134638.5922.
19. J. Melissas et al., “Sleeve gastrectomy - A ‘food limiting’ operation,” Obes. Surg., vol. 18, no. 10, pp. 1251–1256, 2008, doi: 10.1007/s11695-008-9634-4.
20. E. H. Hassan, E. A. Mostafa, and Z. Futooh, “The effect of laparoscopic sleeve gastrectomy on hemoglobin , calcium , and lipid metabolism,” pp. 96–100, 2021, doi: 10.4103/sjamf.sjamf.
21. A. A. ALhaboo & L. F. Bdaiwi, “Methods to assess Vitamin B12 bioavailability and technologies to enhance its absorption,” Egypt. J. Chem., vol. 64, no. 12, pp. 7283–7290, 2020, doi: 10.1093/nutrit/nuy026.
22. N. Steenackers, I. Gesquiere, and C. Matthys, “The relevance of dietary protein after bariatric surgery: What do we know?,” Curr. Opin. Clin. Nutr. Metab. Care, vol. 21, no. 1, pp. 58–63, 2018, doi: 10.1097/MCO.0000000000000437.
23. J. T. Mehsen, Z. S. Madhi, and I. S. Madhi, “Spinal Stenosis : What Outcome Should be Expected ? Review the Latest Evidence Using the Assessment of Multiple Systematic Reviews Appraisal Tool ( AMSTAR ),” Med. J. Babylon, vol. 17, no. 2, pp. 117–121, 2020, doi: 10.4103/MJBL.MJBL.
24. F. Cao et al., “Effect of laparoscopic sleeve gastrectomy on renal function in obese patients,” ANZ J. Surg., vol. 90, no. 4, pp. 514–520, 2020, doi: 10.1111/ans.15767.
25. R. Peterli et al., “Improvement in glucose metabolism after bariatric surgery: Comparison of laparoscopic roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: A prospective randomized trial,” Ann. Surg., vol. 250, no. 2, pp. 234–241, 2009, doi: 10.1097/SLA.0b013e3181ae32e3.
26. A. L. Bjørke-Monsen, S. M. Mikalsen, G. Å. Ueland, J. Aaseth, and J. E. Whist, “Low serum sodium concentrations in patients with obesity normalizes with weight loss,” Clin. Nutr. ESPEN, vol. 41, no. xxxx, pp. 405–411, 2021, doi: 10.1016/j.clnesp.2020.10.011.
27. N. Kodra, R. Khella, B. G. Nudelman, and B. Dawkins, “Oral Potassium Malabsorption Following Bariatric Surgery,” Cureus, vol. 14, no. 8, pp. 2–3, 2022, doi: 10.7759/cureus.28607.
28. E. Z. K. ; L. F. Bdaiw, “Biochemical study of Visfatin Hormone and Some Biochemical Parameters in The Serum of Obese Patients in Nineveh Governorate,” Egypt. J. Chem., 2022, doi: 10.1192/bjp.bp.114.145177.
29. M. Ruz et al., “Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass: A randomized study using 2 supplements,” Am. J. Clin. Nutr., vol. 94, no. 4, pp. 1004–1011, 2011, doi: 10.3945/ajcn.111.018143.
Published
2023-08-05
How to Cite
Ibrahim, S. J., Bdaiwi, L. F., Al Sherbit, M. A., & Zidan, Y. F. (2023). Evaluation the Role of Vitamin B12 and Ferritin in Obese Patients Who Underwent Gastric Sleeve Surgery. Central Asian Journal of Medical and Natural Science, 4(4), 302-310. Retrieved from https://cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1701
Section
Articles