The role of the genetic polymorphism of the gene - oncosupressor TP53 rs 17884159 in women with cervical intraepithelial neoplasia
Keywords:
cervical intraepithelial neoplasia (CIN), human papillomavirus (HPV) viruses, oncosupressor TP53 rs 17884159, heterozygous C/T genotype, C/T and T/T genotypes
Abstract
Analysis of the frequency of distribution of alleles and genotypes of polymorphism of the TP53 rs 17884159 gene depending on the severity of the disease at the time of the study showed negative associations, consisting in a significant increase in the prevalence of carriage of the heterozygous C/T genotype associated with the severity of CIN: carriage of the heterozygous C/T genotype increases the risk of pathology in LSIL 1.947 times; HSIL CIN ΙΙ - 3.957 times and HSIL CIN ΙΙΙ - 2.250 times. In our studies, the carriage of unfavorable C/T and T/T genotypes is associated with an increase in the severity of CIN
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20. Luttmer R., De Strooper L.M., Steenbergen R.D., et al. Management of high-risk HPV-positive women for detection of cervical (pre)cancer. Expert Rev Mol Diagn. 2016; 16(9): 961–74.
21. Prives C., Lowe S. W. Cancer: Mutant p53 and chromatin regulation // Nature. 2015. V. 525. P. 199–200.
22. Zhu J. et al. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth // Nature. 2015. V. 525. P. 206–211. – 2014. – Vol.58. – № 9. – P.5111–5116.
Published
2021-05-07
How to Cite
I.A, K. (2021). The role of the genetic polymorphism of the gene - oncosupressor TP53 rs 17884159 in women with cervical intraepithelial neoplasia. Central Asian Journal of Medical and Natural Science, 2(3), 31-36. https://doi.org/10.17605/cajmns.v2i3.170
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Copyright (c) 2021 Kamilova I.A
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